Results 71 to 80 of about 6,785 (163)
Predicting HLA CD4 Immunogenicity in Human Populations
Frontiers in Immunology, 2018 BackgroundPrediction of T cell immunogenicity is a topic of considerable interest, both in terms of basic understanding of the mechanisms of T cells responses and in terms of practical applications.
Sandeep Kumar Dhanda +13 more
doaj +1 more source
Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.ABSTRACT Background With increased transmission but reduced disease severity, the Omicron SARS‐CoV‐2 variants have contributed to the multifaceted transition of COVID‐19 from a global pandemic to an endemic disease. Nonetheless, the persistence of hypermutable viral variants and their ability to infect both vaccinated and previously infected ...
Katherine L. Li +2 more
wiley +1 more source
, 2017 The immune system focuses on and responds to very few representative immunodominant epitopes from pathogenic insults. However, due to the complexity of the antigen processing, understanding the parameters that lead to immunodominance has proved difficult.
Erika Darrah +4 more
core +1 more source
iNew Medicine, Volume 2, Issue 2, June 2026.This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
CD4 T-Cell Memory Responses to Viral Infections of Humans Show Pronounced Immunodominance Independent of Duration or Viral Persistence [PDF]
, 2013 Little is known concerning immunodominance within the CD4 T-cell response to viral infections and its persistence into long-term memory. We tested CD4 T-cell reactivity against each viral protein in persons immunized with vaccinia virus (VV), either ...
Schiffer, JT +9 more
core +2 more sources
Variable and Variant Protein Multigene Families in Babesia bovis Persistence
Pathogens, 2019 Cattle infected with Babesia bovis face a bifurcated fate: Either die of the severe acute infection, or survive and carry for many years a highly persistent but generally asymptomatic infection.
David R. Allred
doaj +1 more source
SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design
Reviews in Medical Virology, Volume 36, Issue 3, May 2026.ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer +2 more
wiley +1 more source
Confronting Complexity: Real-World Immunodominance in Antiviral CD8+ T Cell Responses [PDF]
, 2006 Antiviral CD8+ T cells respond to only a minute fraction of the potential peptide determinants encoded by viral genomes. Immunogenic determinants can be ordered into highly reproducible hierarchies based on the magnitude of cognate CD8+ T cell responses.
Jonathan W. Yewdell +1 more
core +1 more source
The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance [PDF]
Royal Society Open Science, 2015 Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes.
Clemente F. Arias +4 more
doaj +1 more source
Insights into Api m 10‐Isoforms and Splice Variants: More Than One Major IgE‐Binding Epitope
Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.The structural, clinical and preclinical insights into Api m 10 and its immunodominant epitopes gained in this study provide substantial insights for the future development of active and passive VIT as well as further treatment approaches. ABSTRACT Background Honey bee venom (HBV) often triggers severe IgE‐mediated allergies.
Kathrin Elisabeth Paulus‐Tremel +7 more
wiley +1 more source