Results 71 to 80 of about 287 (117)

Indirect ELISA Using Multi-Antigenic Dominants of VP1, VP2, and VP3 Recombinant Protein to Detect Antibodies Against Senecavirus A in Pigs

Veterinary Sciences
Senecavirus A (SVA) is an emerging pathogen that poses a significant threat to the global swine industry. With the advent of SVA vaccines, there is a growing need to develop serological diagnostic methods for evaluating vaccine-induced immunity.
Zenglin Wang, Dexin Li, Yufang Li, Yunjing Zhang, Junhua Deng, Liying Hao, Kegong Tian, Xiangdong Li   +7 more
doaj   +1 more source

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

Advanced Science, Volume 12, Issue 18, May 15, 2025.
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf, Ben S. Ou, Ye Eun Song, Joshua J. Carter, Jerry Yan, Carolyn K. Jons, Christopher O. Barnes, Eric A. Appel   +7 more
wiley   +1 more source

Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection

Frontiers in Immunology, 2018
Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South- and Central America. Like with other flaviviruses, protective immunity is strongly dependent on potently neutralizing antibodies (Abs) directed against the viral ...
Maximilian Koblischke, Karin Stiasny, Stephan W. Aberle, Stefan Malafa, Georgios Tsouchnikas, Julia Schwaiger, Michael Kundi, Franz X. Heinz, Judith H. Aberle   +8 more
doaj   +1 more source

Evaluation of the Epitogen Lyme Detect IgG ELISA: a novel peptide multiplexing approach

Microbiology Spectrum
Lyme Borreliosis (LB), or Lyme disease, is a growing health concern caused by Borrelia burgdorferi sensu lato (Bbsl) bacteria transmitted through tick bites, and untreated cases can lead to severe health complications.
Tiehui Wang, Alex Wang, Rodanthi Zindrili, Elena Melis, Swapna Guntupalli, Robin Brittain-Long, Mirela Delibegovic, Christopher J. Secombes, Nimesh Mody, Sally Mavin, Ralfs Buks   +10 more
doaj   +1 more source

MHC Class II Auto-antigen Processing and Presentation is Unconventional

Frontiers in Immunology, 2015
Antigen presentation is highly critical in adoptive immunity. Only by interacting with antigens presented by MHC Class II molecules, can helper T cells be stimulated to fight infections or diseases.
Scheherazade eSadegh-Nasseri, Aeryon eKim   +1 more
doaj   +1 more source

In Search of Immunodominant Minor Histocompatibility Antigens [PDF]

Biology of Blood and Marrow Transplantation, 2013
survival. Larger retrospective studies should parse out relapse risk in specific cytogenetic subgroups, to offer more guidance to the practicing clinician. Our hope is that this and other retrospective studies of MRD monitoring leads to an assessment of the prognostic impact of MRD in well-defined molecular and cytogenetic subsets of AML.
openaire   +2 more sources

Identification of mouse CD4+ T cell epitopes in SARS-CoV-2 BA.1 spike and nucleocapsid for use in peptide:MHCII tetramers

Frontiers in Immunology
Understanding adaptive immunity against SARS-CoV-2 is a major requisite for the development of effective vaccines and treatments for COVID-19. CD4+ T cells play an integral role in this process primarily by generating antiviral cytokines and providing ...
Laura Bricio-Moreno, Laura Bricio-Moreno, Laura Bricio-Moreno, Juliana Barreto de Albuquerque, Juliana Barreto de Albuquerque, Juliana Barreto de Albuquerque, Jake M. Neary, Jake M. Neary, Thao Nguyen, Thao Nguyen, Lucy F. Kuhn, Lucy F. Kuhn, YeePui Yeung, YeePui Yeung, Kathryn M. Hastie, Sara Landeras-Bueno, Eduardo Olmedillas, Chitra Hariharan, Anusha Nathan, Anusha Nathan, Matthew A. Getz, Alton C. Gayton, Ashok Khatri, Ashok Khatri, Gaurav D. Gaiha, Gaurav D. Gaiha, Gaurav D. Gaiha, Erica Ollmann Saphire, Erica Ollmann Saphire, Andrew D. Luster, Andrew D. Luster, Andrew D. Luster, James J. Moon, James J. Moon, James J. Moon, James J. Moon   +35 more
doaj   +1 more source

Comprehending B-Cell Epitope Prediction to Develop Vaccines and Immunodiagnostics

Frontiers in Immunology, 2022
Salvador Eugenio C. Caoili
doaj   +1 more source

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

Cell Reports, 2017
Rapidly evolving pathogens such as HIV or influenza can quickly mutate their antigenic profiles, reducing the efficacy of conventional vaccines. Despite this challenge, functionally required epitopes are highly conserved among heterologous viral strains ...
Murillo Silva, Thao H. Nguyen, Phaethon Philbrook, Matthew Chu, Olivia Sears, Stephen Hatfield, Robert K. Abbott, Garnett Kelsoe, Michail V. Sitkovsky   +8 more
doaj   +1 more source

The immunodominant T cell epitopes of the mycolyl-transferases of the antigen 85 complex of M. tuberculosis.

Frontiers in Immunology, 2014
The Ag85 complex is a 30-32 kD family of three proteins (Ag85A, Ag85B and Ag85C), which all three possess enzymatic mycolyl-transferase activity involved in the coupling of mycolic acids to the arabinogalactan of the cell wall and in the biogenesis of ...
Kris eHuygen
doaj   +1 more source