Results 91 to 100 of about 6,785 (163)

Comprehending B-Cell Epitope Prediction to Develop Vaccines and Immunodiagnostics

Frontiers in Immunology, 2022
Salvador Eugenio C. Caoili
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Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

Cell Reports, 2017
Rapidly evolving pathogens such as HIV or influenza can quickly mutate their antigenic profiles, reducing the efficacy of conventional vaccines. Despite this challenge, functionally required epitopes are highly conserved among heterologous viral strains ...
Murillo Silva, Thao H. Nguyen, Phaethon Philbrook, Matthew Chu, Olivia Sears, Stephen Hatfield, Robert K. Abbott, Garnett Kelsoe, Michail V. Sitkovsky   +8 more
doaj   +1 more source

The post-2009 influenza pandemic era : time to revisit antibody immunodominance [PDF]

, 2018
The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift ...
Van Reeth, Kristien, Kristien Van Reeth
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Defining and Manipulating B Cell Immunodominance Hierarchies to Elicit Broadly Neutralizing Antibody Responses against Influenza Virus

, 2022
© 2020 Elsevier Inc. The antibody repertoire possesses near-limitless diversity, enabling the adaptive immune system to accommodate essentially any antigen.
Lingwood, Daniel, Rohrer, Daniel, Lonberg, Nils, Sangesland, Maya, Barnes, Ralston M, Amitai, Assaf, Chakraborty, Arup K   +6 more
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The immunodominant T cell epitopes of the mycolyl-transferases of the antigen 85 complex of M. tuberculosis.

Frontiers in Immunology, 2014
The Ag85 complex is a 30-32 kD family of three proteins (Ag85A, Ag85B and Ag85C), which all three possess enzymatic mycolyl-transferase activity involved in the coupling of mycolic acids to the arabinogalactan of the cell wall and in the biogenesis of ...
Kris eHuygen
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Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens

, 1999
We have examined the mechanisms involved in immunodominance in two different experimental models: the cytotoxic T lymphocyte (CTL) response in B6 mice against minor histocompatibility antigens of BALB.B mice, and the response of B6 mice against a mixture
Elisabeth Z Wolpert, Grufman, P, Klas Kärre, Sandberg, JK, Kärre, K,, Wolpert, EZ, Johan K Sandberg, Per Grufman   +7 more
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Impact of ChAdOx1 or DNA Prime Vaccination on Magnitude, Breadth, and Focus of MVA-Boosted Immunogen-Specific T Cell Responses

Vaccines
The efficacy of anti-viral T-cell vaccines may greatly depend on their ability to generate high-magnitude responses targeting a broad range of different epitopes. Recently, we created the HIV T-cell immunogen HTI, designed to generate T-cell responses to
Alex Olvera, Luis Romero-Martin, Bruna Oriol-Tordera, Miriam Rosas-Umbert, Tuixent Escribà, Beatriz Mothe, Christian Brander   +6 more
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Emergence of CD4+ and CD8+ Polyfunctional T Cell Responses Against Immunodominant Lytic and Latent EBV Antigens in Children With Primary EBV Infection

Frontiers in Microbiology, 2018
Long term carriers were shown to generate robust polyfunctional T cell (PFC) responses against lytic and latent antigens of Epstein-Barr virus (EBV). However, the time of emergence of PFC responses against EBV antigens, pattern of immunodominance and ...
Janice K. P. Lam, K. F. Hui, Raymond J. Ning, X. Q. Xu, K. H. Chan, Alan K. S. Chiang   +5 more
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Immunodominance in a complex host-pathogen system.

In experimental infection models with simple organisms, pathogen-specific immune responses recognize only a small fraction of potential epitopes encoded by the genome. This phenomenon is termed immunodominance. We propose the first comprehensive study of

core  

Supplementary Figure S1 from HLA Class I–Associated Immunodominance Affects CTL Responsiveness to an ESO Recombinant Protein Tumor Antigen Vaccine

, 2009
Supplementary Figure S1 from HLA Class I–Associated Immunodominance Affects CTL Responsiveness to an ESO Recombinant Protein Tumor Antigen ...
Bo Dupont (14974066), Alice Yeh (3184977), Gilles Bioley (14898374), Maha Ayyoub (57333), Nina Bhardwaj (247367), Danila Valmori (57332), Philippe Guillaume (137747), Immanuel Luescher (347001), Gregory Mears (14974069), Lloyd J. Old (14888781)   +9 more
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