Results 91 to 100 of about 287 (117)
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2005
Preface.List of Contributors.Color Plates.I Mechanics of Antigen Processing.1 Class I MHC Antigen Processing (Peter J. Miller and Edward J. Collins).1.1 Introduction.1.2 Properties of MHC.1.3 Properties of Peptides.1.4 Cytosolic Processing.1.5 Peptide Transport.1.6 Class I MHC Maturation and Peptide Loading.1.7 Immunodominance and Class I MHC Peptide ...
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Preface.List of Contributors.Color Plates.I Mechanics of Antigen Processing.1 Class I MHC Antigen Processing (Peter J. Miller and Edward J. Collins).1.1 Introduction.1.2 Properties of MHC.1.3 Properties of Peptides.1.4 Cytosolic Processing.1.5 Peptide Transport.1.6 Class I MHC Maturation and Peptide Loading.1.7 Immunodominance and Class I MHC Peptide ...
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Immunodominance: intramolecular competition between T cell epitopes
The Journal of Immunology, 1991Abstract We have used an approach of linking previously characterized T cell epitopes into immunologically complex synthetic peptides in order to investigate the mechanism of immunodominance. Our results show that first, cI12-26 is highly dominant following immunization with the lambda repressor (cI) protein, but is a minor epitope in ...
D L, Perkins +4 more
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Immunodominant minor histocompatibility antigens: the major ones
Immunology Today, 1998Abstract Minor histocompatibility antigens (MiHAs) are extremely numerous—possibly up to 720 in mice—and have been regarded as an `immunogenetic nightmare' in transplantation. Here, Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant ...
C, Perreault, D C, Roy, C, Fortin
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2006
The focusing of cellular immunity toward one, or just a few, antigenic determinant, even during immune responses to complex microorganisms or antigens, is known as immunodominance. Although described in many systems, the mechanisms of determinant immunodominance are only just beginning to be appreciated, especially in relation to the interplay between ...
Weisan, Chen, James, McCluskey
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The focusing of cellular immunity toward one, or just a few, antigenic determinant, even during immune responses to complex microorganisms or antigens, is known as immunodominance. Although described in many systems, the mechanisms of determinant immunodominance are only just beginning to be appreciated, especially in relation to the interplay between ...
Weisan, Chen, James, McCluskey
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Carbohydrate-associated Immunodominant Epitope(s) of CA215
Immunological Investigations, 2011RP215 monoclonal antibody (Mab) was initially generated against OC-3-VGH ovarian cancer cells and was shown to react with a cancer-associated carbohydrate epitope in glycoproteins designated as CA215. Additional five high affinity Mabs, designated as RCA-10, -100, -104, -110 and -111, respectively, were generated by using affinity-purified CA215 as the
Gregory, Lee +7 more
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Intestinal digestive resistance of immunodominant gliadin peptides
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002Two recently identified immunodominant epitopes from α-gliadin account for most of the stimulatory activity of dietary gluten on intestinal and peripheral T lymphocytes in patients with celiac sprue. The proteolytic kinetics of peptides containing these epitopes were analyzed in vitro using soluble proteases from bovine and porcine pancreas and brush ...
Felix, Hausch +4 more
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Polymorphism in the Dirofilaria immitis immunodominant antigen gene
Journal of Helminthology, 1999Dg2, a gene encoding a 34 kDa immunodominant antigen of Dirofilaria immitis was cloned and demonstrated to be specifically expressed in the larval stage. In this study, a newly constructed genomic DNA library was screened by hybridization with Dg2.
K, Sugane, K, Nakayama, H, Kato
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Immunodominance Across HLA Polymorphism: Implications for Cancer Immunotherapy
Journal of Immunotherapy, 1998Recent advances in the understanding of the mechanisms leading to tumor recognition by the immune system have shown that, at least in the case of human melanoma, the majority of cytotoxic T lymphocytes (CTL) identified in association with in vivo tumor regression after interleukin-2 therapy recognize nonmutated molecules expressed by most melanoma ...
C J, Kim, D R, Parkinson, F, Marincola
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Immunodominant IgE Epitopes of Der p 5 Allergen
Protein & Peptide Letters, 2018Der p 5 is an important allergen of Dermatophagoides pteronyssinus that plays a key role in allergic airway diseases. Its three dimensional structure (PDB 3MQ1) consists of three anti-parallel α-helices arranged in a helical bundle. Aggregation of Der p5 can modulate its allergenicity.
Lahiani, Sadjia +7 more
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SPATIOTEMPORAL DYNAMICS IN A MODEL OF IMMUNODOMINANCE
Journal of Biological SystemsAdapative immune response to viral infection is mediated by cytotoxic T-lymphocytes (CTLs) eliminating infected cells and virus-neutralizing antibodies produced by B-lymphocytes. Different epitopes, that is, some parts of antigens, stimulate clonal expansion of the corresponding lymphocytes.
NAYANA MUKHERJEE, VITALY VOLPERT
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