Results 101 to 110 of about 6,785 (163)

Design Challenges for HIV-1 Vaccines Based on Humoral Immunity

Frontiers in Immunology, 2014
Neil S Greenspan
doaj   +1 more source

T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses [Elektronisk resurs]

, 2002
Immunodominance is a process in which the immune response focuses on one or a few of all potential epitopes that exists within an antigen. The mechanisms for immunodominance have not yet been determined.
Grufman, P,
core  

T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses

, 2002
Immunodominance is a process in which the immune response focuses on one or a few of all potential epitopes that exists within an antigen. The mechanisms for immunodominance have not yet been determined.
Per Grufman (825726)
core   +1 more source

Duration of alloantigen presentation and avidity of T cell antigen recognition correlate with immunodominance of CTL response to minor histocompatibility antigens.

, 2004
CD8 T lymphocytes (CTL) responsive to immunodominant minor histocompatibility (minor H) Ags are thought to play a disproportionate role in allograft rejection in MHC-identical solid and bone marrow transplant settings.
Yoshimura, Y, Christianson, G J, Ajayi, W U, Yadav, R, Roopenian, D C, Joyce, S   +5 more
core   +1 more source

Antigenic oscillations and shifting immunodominance in HIV-1 infections.

, 1995
A typical protein antigen contains several epitopes that can be recognized by cytotoxic T lymphocytes (CTL), but in a characteristic antiviral immune response in vivo, CTL recognize only a small number of these potential epitopes, sometimes only one ...
Phillips, Rodney, Rowland-Jones, Sarah, Nowak, MA, Sigmund, K, Klenerman, Paul, Bangham, CR, McAdam, S, Klenerman, P, May, RM, Köppe, B, Lalloo, DG, Rowland-Jones, S, Phillips, RE   +12 more
core   +1 more source

Computational Study of Vaccination Strategies to Change B Cell Immunodominance

B cell Immunodominance refers to the phenomenon where B cells that target certain epitopes of a pathogen are preferentially selected among the B cells that potentially target diverse epitopes presented on a pathogenic protein.
Yang, Leerang
core  

The Altered Neonatal CD8+ T Cell Immunodominance Hierarchy during Influenza Virus Infection Impacts Peptide Vaccination

Neonates are more susceptible to influenza virus infection than adults, resulting in increased morbidity and mortality and delayed clearance of the virus.
J. Louise Lines, Luke Heil, Samantha Jewell, Beth A. Garvy   +3 more
core   +1 more source

Immunodominance hierarchy of influenza A haemagglutinin antigenic sites: an observational cohort study across distinct exposure histories. [PDF]

EBioMedicine
Martínez-Guevara JL, Lai TY, Mishra M, Hoang MT, Shea W, Page CK, Sinywimaanzi P, Simulundu E, Rothman RE, Pekosz A, Joan Fenstermacher KZ, Sutcliffe CG, Simon V, Palese P, Sun W, González-Domínguez I.   +15 more
europepmc   +1 more source

Keystone Epitope Theory: An Ecological Perspective on RNA Viruses, Tumor Immunoediting, and Vaccine Design. [PDF]

Pathog Immun
Mallal S, Asiaee A.
europepmc   +1 more source

From Universal Aspiration to Precision Immunization: A Hypothesis Framework for Antigen-Defined, HLA-Restricted Cancer Vaccines. [PDF]

Vaccines (Basel)
Niazi SK.
europepmc   +1 more source