Results 141 to 150 of about 470,180 (352)

A Computational Assay to Design an Epitope-Based Peptide Vaccine Against Saint Louis Encephalitis Virus

, 2013
Saint Louis encephalitis virus, a member of the flaviviridae subgroup, is a culex mosquito-borne pathogen. Despite severe epidemic outbreaks on several occasions, not much progress has been made with regard to an epitope-based vaccine designed for Saint ...
Md. Anayet Hasan, Mehjabeen Hossain, Md. Jibran Alam, Anayet Hasan Md., Jibran Alam Md.   +4 more
core   +1 more source

Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains [PDF]

, 2014
Two long synthetic peptides representing the dimorphic and constant C-terminal domains of the two allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates.
Kajava, Andrey V., Diakité, Mahamadou, Felger, Ingrid, Servis, Catherine, Corradin, Giampietro, D’Alessandro, Alba, Moret, Remy, Balam, Saidou, Nebie, Issa, Kajava, Andrey V, Spertini, François, Olugbile, Sope, Smith, Thomas, D'Alessandro, Alba, Frank, Geraldine, Tanner, Marcel   +15 more
core   +1 more source

Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus

Journal of Immunological Research, 2018
Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target
U. Adhikari, U. Adhikari, M. Tayebi, M. M. Rahman   +3 more
semanticscholar   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Application of built-in adjuvants for epitope-based vaccines

PeerJ, 2019
Several studies have shown that epitope vaccines exhibit substantial advantages over conventional vaccines. However, epitope vaccines are associated with limited immunity, which can be overcome by conjugating antigenic epitopes with built-in adjuvants (e.
Y. Lei, Fu-Rong Zhao, Junjun Shao, Yangfan Li, Shi-Fang Li, Hui-Yun Chang, Yongguang Zhang   +6 more
semanticscholar   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Antibody recognition of a highly conserved influenza virus epitope: implications for universal prevention and therapy

Science, 2009
Influenza virus presents an important and persistent threat to public health worldwide, and current vaccines provide immunity to viral isolates similar to the vaccine strain.
D. Ekiert, G. Bhabha, M. Elsliger, R. Friesen, M. Jongeneelen, M. Throsby, J. Goudsmit, I. Wilson   +7 more
semanticscholar   +1 more source

A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits

Toxins, 2017
As part of an effort to engineer ricin antitoxins and immunotherapies, we previously produced and characterized a collection of phage-displayed, heavy chain-only antibodies (VHHs) from alpacas that had been immunized with ricin antigens.
Amanda Y. Poon, David J. Vance, Yinghui Rong, Dylan Ehrbar, Nicholas J. Mantis   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.

, 2002
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach.
Lukey, Pauline T, Abdulrahman S. Hammond, McAdam, Keith PWJ, Klein, Michèl R, Jaye, Assan, Smith, Steve M, Michèl R. Klein, Assan Jaye, Steve M. Smith, Hammond, Abdulrahman S, Pauline T. Lukey, Keith P. W. J. McAdam   +11 more
core   +1 more source