Results 141 to 150 of about 326,590 (304)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry

eLife
Antibodies are a major component of adaptive immunity against invading pathogens. Here, we explore possibilities for an analytical approach to characterize the antigen-specific antibody repertoire directly from the secreted proteins in convalescent serum.
Douwe Schulte, Marta Šiborová, Lukas Käll, Joost Snijder   +3 more
doaj   +1 more source

Epitope A comprises an evolving GII.4 blockade epitope recognized by NVB 114, 111 and 43.9.

, 2012
Hu mAb PGM binding blockade activity against GII.4.1987 epitope-exchanged VLPs for NVB 114 (Panel A) and Epitope A exchanged between GII.4.1987 and GII.4.2006 (Panels C and E).
Davide Corti (163945), Antonio Lanzavecchia (75057), Eric F. Donaldson (163942), Kari Debbink (163955), Ralph S. Baric (163960), Lisa C. Lindesmith (163928), Martina Beltramello (163935), Jesica Swanstrom (163950)   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

TCR-H: explainable machine learning prediction of T-cell receptor epitope binding on unseen datasets

Frontiers in Immunology
Artificial-intelligence and machine-learning (AI/ML) approaches to predicting T-cell receptor (TCR)-epitope specificity achieve high performance metrics on test datasets which include sequences that are also part of the training set but fail to ...
Rajitha Rajeshwar T., Rajitha Rajeshwar T., Rajitha Rajeshwar T., Omar N. A. Demerdash, Omar N. A. Demerdash, Jeremy C. Smith, Jeremy C. Smith, Jeremy C. Smith   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Distinct types of VHHs in Alpaca

Frontiers in Immunology
IntroductionVHHs (VH of heavy-chain-only antibodies) represent a unique alternative to Q7 conventional antibodies because of their smaller size, comparable binding affinity and biophysical properties.
Xinhao Wang, Lu Zhang, Yao Zhang, Jiaguo Li, Wenfeng Xu, Weimin Zhu   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Two-epitope EMM.

, 2016
Panel A: A schematic for the two-epitope EMM. The HA antigen has two epitopes: X on the head and S on the stem. Binding of antibodies specific for these epitopes masks them and masked epitope is indicated by O.
Veronika I. Zarnitsyna (381901), Jennie Lavine (370168), Ali Ellebedy (2851955), Rafi Ahmed (63047), Rustom Antia (29429)   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source