Results 151 to 160 of about 470,180 (352)

Construction of Epitope-Based Peptide Vaccine Against SARS-CoV-2: Immunoinformatics Study

, 2020
Recently, a novel coronavirus (SARS-CoV-2) appeared which is conscientious for the current outbreak in China and rapidly spread worldwide. Unluckily, there is no approved vaccine found against SARSCoV-2.
Viol Dhea Kharisma, Arif Nur Muhammad Ansori   +1 more
core   +1 more source

Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatic approach

Инфекция и иммунитет
Background.An outbreak of SARS-CoV-2 in 2019 has brought a great challenge to public health and rapid identification of immune epitopes for designing an effective vaccine for different variants of SARS-CoV-2 is necessary at the time of the pandemic ...
V. Alamdari-Palang, Z. Dehghan, M. Kian, S. Zonar, J. Fallahi, M. Sisakht, S. Khajeh, V. Razban   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Generation of a Peptide Vaccine Candidate against Falciparum Placental Malaria Based on a Discontinuous Epitope

, 2020
In pregnant women, Plasmodium falciparum-infected red blood cells adhere to the placenta via the parasite protein VAR2CSA. Two vaccine candidates based on VAR2CSA are currently in clinical trials; however, these candidates failed to elicit strain ...
Mitran, Catherine J, Stephanie K. Yanow, Good, Michael F, Catherine J. Mitran, Lauren M. Higa, Michael F. Good, Higa, Lauren M, Yanow, Stephanie K   +7 more
core   +1 more source

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Nature Communications, 2019
The magnitude of T cell responses to infection is a function of the naïve T cell repertoire combined with the context and duration of antigen presentation. Using mass spectrometry, we identify and quantify 21 class 1 MHC-restricted influenza A virus (IAV)
Ting Wu, Jing Guan, A. Handel, D. Tscharke, J. Sidney, A. Sette, L. Wakim, Xavier Y. X. Sng, P. Thomas, N. Croft, A. Purcell, Nicole L. La Gruta   +11 more
semanticscholar   +1 more source

Identification of CD4+ T-cell Epitopes on Mycobacterium Tuberculosis- Secreted MPB51 Protein in C57BL/6 Mice

پزشکی بالینی ابن سینا, 2006
Introduction & Objective: Both CD4+ type 1 helper (Th1) cells and CD8+ T cells play effective roles in protection against Mycobacterium tuberculosis infection.
Ali Reza Rafiei, Yukido Kuade
doaj  

Development of a subunit vaccine against the cholangiocarcinoma causing Opisthorchis viverrini: a computational approach

Frontiers in Immunology
Opisthorchis viverrini is the etiological agent of the disease opisthorchiasis and related cholangiocarcinoma (CCA). It infects fish-eating mammals and more than 10 million people in Southeast Asia suffered from opisthorchiasis with a high fatality rate.
Mohibullah Shah, Farva Sitara, Asifa Sarfraz, Muhammad Shehroz, Tehreem Ul Wara, Asia Perveen, Najeeb Ullah, Aqal Zaman, Umar Nishan, Sarfraz Ahmed, Riaz Ullah, Essam A. Ali, Suvash Chandra Ojha   +12 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Molecular mimicry: Can epitope mimicry induce autoimmune disease?

, 1997
Mimicry of host antigens by infectious agents may induce cross-reactive autoimmune responses to epitopes within host proteins which, in susceptible individuals, may tip the balance of immunological response versus tolerance toward response and ...
Davies, J.M., Davies, J. M., Davies, Janet M., Janet M Davies   +3 more
core   +1 more source

An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction

Journal of Immunological Research, 2016
Identification of B‐cell epitopes is a fundamental step for development of epitope‐based vaccines, therapeutic antibodies, and diagnostic tools. Epitope‐based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in‐
L. Potocnakova, M. Bhide, L. Pulzova
semanticscholar   +1 more source