Results 171 to 180 of about 554,474 (398)

Epitopes of human interferon-alpha defined by the reaction of monoclonal antibodies with alpha interferons and interferon analogues. [PDF]

, 1987
Joyce Taylor‐Papadimitriou, M Shearer, D Griffin   +2 more
openalex   +1 more source

Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy.

Journal of the American Society of Nephrology, 2015
Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized by 90% of human ...
M. Fresquet, T. Jowitt, J. Gummadova, R. Collins, Ronan O’Cualain, E. Mckenzie, R. Lennon, P. Brenchley   +7 more
semanticscholar   +1 more source

The essence of epitopes. [PDF]

The Journal of experimental medicine, 1994
L. D. Barber, Peter Parham
openaire   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Epitope mapping for the anti-rabbit cholesteryl ester transfer protein monoclonal antibody that selectively inhibits triglyceride transfer

Journal of Lipid Research, 1999
Among the monoclonal antibodies (Mab) against rabbit plasma cholesteryl ester transfer protein (CETP), Mab 14-8F cross-reacted with human CETP and selectively inhibited triglyceride transfer but not cholesteryl ester transfer (Ko, K. W. S., T.
Kazunori Saito, Ki-ichiro Kobori, Hideyuki Hashimoto, Sachiko Ito, Mitsuhisa Manabe, Shinji Yokoyama   +5 more
doaj  

Epitope analysis for influenza vaccine design [PDF]

arXiv, 2004
Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the vaccine-influenza sequence difference. We use a theory from statistical mechanics to quantify the non-monotonic immune
arxiv  

Serologically defined linear epitopes in the envelope protein of dengue 2 (Jamaica strain 1409) [PDF]

, 1989
John Aaskov, H. Mario Geysen, Thomas Mason   +2 more
openalex   +1 more source

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

Science, 2011
An antibody against a conserved epitope broadly neutralizes group 2 influenza viruses. Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses.
D. Ekiert, R. Friesen, G. Bhabha, Ted H. J. Kwaks, M. Jongeneelen, Wenli Yu, C. Ophorst, F. Cox, Hans J. W. M. Korse, Boerries Brandenburg, R. Vogels, J. Brakenhoff, R. Kompier, Martin H. Koldijk, L. Cornelissen, L. Poon, M. Peiris, W. Koudstaal, I. Wilson, J. Goudsmit   +19 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

A Nonconventional Analysis of CD$4^{+}$ and CD$8^{+}$ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection [PDF]

arXiv, 2017
A mathematical model from a previous work was re-fitted and analyzed for experimental data regarding the cellular immune response to the lymphocytic choriomeningitis virus. Specifically, the $CD8^{+}$ T cell response to six MHC class I-restricted epitopes (GP* and NP*) and $CD4^{+}$ T cell responses to two MHC class II-restricted epitopes\cite ...
arxiv