Results 171 to 180 of about 472,049 (341)

H5N1 strain-specific Hemagglutinin CD4+ T cell epitopes restricted by HLA DR4

, 2009
Junbao Yang, John A. Gebe, Laurie Huston, Eddie A. James, Venus Tan, Betty B. Yue, Gerald T. Nepom, William W. Kwok   +7 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A poxvirus model reveals general correlates of antigen presentation and immunogenicity for viral CD8⁺ T cell epitopes. [PDF]

Sci Adv
Witney MJ, Croft NP, Wong YC, Smith S, Flesch IEA, Keller E, Lin LC, Li Y, La Gruta NL, Purcell AW, Tscharke DC.   +10 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Functional NK engagers from OmniClic, a common light-chain platform producing fully human-sequence antibodies in a chicken host species. [PDF]

MAbs
Zeng B, Mechin I, Mowrey D, Rivera GS, Nyvall HG, Suresh S, Burke JE, Harriman W, Chen B, Abdiche Y.   +9 more
europepmc   +1 more source

A single mouse monoclonal antibody, E58 modulates multiple IgE epitopes on group 1 cedar pollen allergens

, 2016
Randall M. Goldblum, Bo Ning, Barbara M. Judy, Luis Marcelo F. Holthauzen, Julius van Bavel, Atsushi Kamijo, Terumi Midoro‐Horiuti   +6 more
openalex   +1 more source

Analysis of Bm86 conserved epitopes: is a global vaccine against Cattle Tick Rhipicephalus microplus possible? [PDF]

, 2018
I. M. Z. Blecha, Bárbara Guimarães Csordas, André de Abreu Rangel Aguirre, Rodrigo Casquero Cunha, Marcos Valério Garcia, Renato Andreotti   +5 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Repeated vaccination with homologous influenza hemagglutinin broadens human antibody responses to unmatched flu viruses. [PDF]

Elife
Deng Y, Tang M, Ross TM, Schmidt AG, Chakraborty AK, Lingwood D.   +5 more
europepmc   +1 more source

Absence of the OKT4 epitope on blood T cells and thymus cells in a patient with thymoma, hypogammaglobulinemia, and red blood cell aplasia

, 1985
A I Levinson, James A. Hoxie, Michael J. Kornstein, D. Zembryki, D. M. Matthews, Alan D. Schreiber   +5 more
openalex   +1 more source