Results 181 to 190 of about 470,180 (352)
eLifeAntibodies are a major component of adaptive immunity against invading pathogens. Here, we explore possibilities for an analytical approach to characterize the antigen-specific antibody repertoire directly from the secreted proteins in convalescent serum.
Douwe Schulte +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Introduction: Epitope mimicry as a component cause of autoimmune disease
, 2000 The causes of autoimmune diseases have yet to be fully\ud elucidated. Autoantibodies, autoreactive T cell responses,\ud the presence of a predisposing major histocompatibility\ud complex (MHC) haplotype and responsiveness to corticosteroids are features,
Davies, J. M.
core +1 more source
TCR-H: explainable machine learning prediction of T-cell receptor epitope binding on unseen datasets
Frontiers in ImmunologyArtificial-intelligence and machine-learning (AI/ML) approaches to predicting T-cell receptor (TCR)-epitope specificity achieve high performance metrics on test datasets which include sequences that are also part of the training set but fail to ...
Rajitha Rajeshwar T. +7 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Distinct types of VHHs in Alpaca
Frontiers in ImmunologyIntroductionVHHs (VH of heavy-chain-only antibodies) represent a unique alternative to Q7 conventional antibodies because of their smaller size, comparable binding affinity and biophysical properties.
Xinhao Wang +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The mass spectrometry of selected proteins and peptides [PDF]
The multi-subunit alkene monooxygenase was studied by means of electrospray ionisation mass spectrometry (ESI-MS). The measured relative molecular mass (RMM) values for the epoxygenase and reductase were in good agreement the predicted RMM values ...
Millar, Alan L.
core
Identification of multiple novel HIV-specific T-cell epitopes using HLA-associated HIV polymorphisms [PDF]
, 2009 HIV adapts to T-cell immunity by mutating within or near HLA-restricted CD8-T cell epitopes and therefore HLA allele-specific HIV polymorphisms in a human population mark the immunogenic targets of CD8 T-cell responses relevant to that population in-vivo.
McKinnon, E. +14 more
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