Results 301 to 310 of about 598,048 (347)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Correction: Approaches to reduce succinate accumulation by restoration of succinate dehydrogenase activity in cultured adrenal cells. [PDF]

J Cell Sci
europepmc   +1 more source

<i>In silico</i> prediction of cytotoxic T-cell epitopes from <i>Helicobacter pylori</i> virulence factors using an immunoinformatics approach. [PDF]

BioTechnologia (Pozn)
Chacon DV, Co KA, Enriquez DN, Labarda AL, Manongsong RE, Bragais EK.   +5 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Identification of T-Cell Epitopes and Vaccine Development for African Swine Fever Virus. [PDF]

Vaccines (Basel)
Ni W, Yang H, Zhang N.
europepmc   +1 more source

Epitope mapping of the non-structural protein 2 (NSP2) of rotavirus

Chieh Ren Quek
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A Mutation-Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi-Strains: A Study Using Glycoprotein of LASV. [PDF]

J Cell Mol Med
Mishra SK, Patil RB, Sherpa AT, Borhan Uddin M, Harun-Or-Rashid M, Ahmed M, Dawoud TM, Georrge JJ.   +7 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Development and protective efficacy of multi-epitope vaccine FL46 against cystic echinococcosis. [PDF]

Front Immunol
Jiang T, Mahemuti M, Wang W, Han S, Wu X, Liu H, Chen Q, Mo X, Wang X, Kadiaili A, Hu Y, Cao J, Li S.   +12 more
europepmc   +1 more source