Results 291 to 300 of about 470,180 (352)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

GC B Cells, Tfh Cells, and Influenza bnAbs: Insights for Improving Universal Vaccine Design. [PDF]

Immunol Rev
Inoue T, Ise W, Kurosaki T.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Detection and Genetic Diversity of Bovine Kobuvirus in Diarrheic Calves in Türkiye: Genomic Characterization and Comparative B-Cell Epitope Analysis. [PDF]

Animals (Basel)
Duran-Yelken S, Karayel-Hacıoğlu İ, Bányai K, Marton S, Alkan F.   +4 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen-Driven Autoimmunity. [PDF]

Immunol Rev
Callebaut A, Bruggeman Y, Mathieu C, James EA, Overbergh L.   +4 more
europepmc   +1 more source

EpiMII: Structure-Aware Graph Neural Networks for MHC-II Epitope Generation. [PDF]

Research (Wash D C)
Yuan J, Xu X, Sun ZY, Zhu S, Wei C, Liang T, Ge J, Xie XQ, Chen Y, Feng Z, Hou T, Xue Y.   +11 more
europepmc   +1 more source

Integrative immunoinformatics and structural modeling for the rational design of a multi-epitope vaccine candidate against human cytomegalovirus. [PDF]

Sci Rep
Emmanuel OP, Sandrine MNY, Claude BD, Ogunlakin AD, Ronald BAG, Desire DDP, Aziz T, Aljumaa MA, Alkhatib SN, Sagini HA.   +9 more
europepmc   +1 more source

Lineage Diversification and Evolutionary Dynamics of the <i>Hemagglutinin-Neuraminidase</i> Gene in Mumps Virus Genotype G. [PDF]

Microorganisms
Mizukoshi F, Takada M, Kimura R, Liu W, Hatayama Y, Nishi M, Sato-Fujimoto Y, Kimura A, Kato F, Miyakawa K, Kimura H, Ryo A.   +11 more
europepmc   +1 more source