Results 301 to 310 of about 470,180 (352)

A preS2 aa1-26-specific humoural response marks functional cure in chronic HBV infection. [PDF]

EBioMedicine
Wang YY, Fu JL, Wang WX, Wang HM, Liu SQ, Sun Y, Wang ZW, Li J, Zhou MJ, Li WZ, Zhu MM, Li X, Yang YX, Chen SY, Yang T, Fan X, Xu RN, Jiao YM, Song JW, Zhen C, Zhang M, Shi M, Wang FS, Zhang C.   +23 more
europepmc   +1 more source

Foot-and-mouth disease virus non-structural protein antibody detection: from DIVA serology to repeated-epitope design and multi-species field surveillance. [PDF]

Front Cell Infect Microbiol
Bai Y, Gao K, Wang S, Cheng S, Mao L, Chang Y, Li L, Guo Y, Gao M.   +8 more
europepmc   +1 more source

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Hypervariable epitope constructs as a means of accounting for epitope variability

Vaccine, 1994
Epitope variability is one of the greatest obstacles to development of synthetic peptide vaccines. Based on a recently described hypervariable epitope (aa 414-434) on the envelope glycoprotein (gp130) to simian immunodeficiency virus (SIVmac142), we have developed a novel approach to account for epitope variability.
A Malley, M B Gardner, Murray B Gardner
exaly   +3 more sources

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Cell, 2020
SUMMARY Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity.
James R Heath, Han Si, Nicolas Robine
exaly   +2 more sources

The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design

Frontiers in Immunology, 2017
The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens.
Ward Fleri, Alessandro Sette, Swapnil Mahajan   +2 more
exaly   +2 more sources

Epitope-based vaccine design: a comprehensive overview of bioinformatics approaches.

Drug Discovery Today, 2020
Computational epitope-based vaccine design is the cornerstone of vaccine development. Owing to the selection of proper compositions [antigens (Ags), epitopes, peptide linkers, and intramolecular adjuvants], epitope-based vaccines are considered a cost ...
Sepideh Parvizpour, M. M. Pourseif, J. Razmara, M. Rafi, Y. Omidi   +4 more
semanticscholar   +1 more source

Epitope Mapping

2003
An epitope is defined as the site on an antigen at which an antibody binds. In the case of proteins the epitopes can be classified as continuous (or sequential) and discontinuous according to whether or not the amino acids recognized are close together in the primary sequence or are well-separated but brought together by the folding of the protein. The
J E, Heckels, M, Christodoulides
openaire   +4 more sources

Epitope mapping

Immunology Today, 1991
The immune response to extrinsic and intrinsic antigens involves specific antigen receptors on T and B cells. The precise antigenic determinants, or epitopes, recognized by these receptors are discrete sequences within the native antigen. The ability to identify and manufacture key epitopes in the immune response has important implications for disease ...
A C, Horsfall, F C, Hay, A J, Soltys, M G, Jones   +3 more
openaire   +2 more sources

Epitope Mapping

Molecular Biotechnology, 1994
Monoclonal antibodies (MAbs) are specific immunological tools because they bind to a precise determinant (the epitope) on the surface of a protein. The procedure of identifying the binding site of a MAb is often termed "epitope mapping."
openaire   +4 more sources