Results 311 to 320 of about 598,048 (347)

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Fish isoallergens and variants: database compilation, <i>in silico</i> allergenicity prediction challenges, and epitope-based threshold optimization. [PDF]

Front Bioinform
Limviphuvadh V, Ruethers T, Nguyen MN, Jerry DR, Smith BPC, Wang Y, Miao Y, Andiappan AK, Lopata AL, Maurer-Stroh S.   +9 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Foot-and-mouth disease vaccine with insertion of a 24-amino acid VP1 G-H loop epitope of the Cathay virus provides broad antigenic coverage. [PDF]

Appl Microbiol Biotechnol
Zhang K, Zha J, Sun P, Ouyang Y, Zhang X, Ma X, Liu F, Li D, Bao H, Cao Y, Bai X, Fu Y, Li K, Yuan H, Zhang J, Zhao Z, Wang J, Zhang Q, Liu Z, Lu Z, Li P.   +20 more
europepmc   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Human IgE monoclonal antibodies define two unusual epitopes trapping dog allergen Can f 1 in different conformations. [PDF]

Protein Sci
Khatri K, Ball A, Glesner J, Linn C, Vailes LD, Wünschmann S, Gabel SA, Zhang J, Peebles RS, Borowski T, Mueller GA, Chapman MD, Smith SA, Pomés A, Chruszcz M.   +14 more
europepmc   +1 more source

A versatile silica nanoparticle platform for induction of T cell responses - applied for therapeutic vaccination against HPV16 E6/E7-positive tumors in MHC-humanized mice. [PDF]

Oncoimmunology
Kruse S, Fricke LT, Zottnick S, Schlosser AK, Grabowska AK, Feidt E, Uhl P, Junglas E, Förster JD, Blersch J, Denner P, Günter M, Autenrieth SE, Fava E, Mier W, Kübelbeck A, Riemer AB.   +16 more
europepmc   +1 more source

VaccineDesigner: A Web-Based Tool for Streamlined Multi-Epitope Vaccine Design. [PDF]

Biology (Basel)
Trygoniaris D, Korda A, Paraskeva A, Dushku E, Tzimagiorgis G, Yiangou M, Kotzamanidis C, Malousi A.   +7 more
europepmc   +1 more source

Severity-dependent IgG epitope profiling in COVID-19 reveals differential recognition of pathogen-derived antigens. [PDF]

Front Immunol
do Nascimento LA, Machado N, Borges JVDS, Fagundes BO, Bergamasco IS, Sgnotto FDR, Bachi ALL, Sato MN, Victor JR.   +8 more
europepmc   +1 more source

Residue 301-dependent epitope mapping reveals the molecular basis for GPV/MDPV serotype discrimination by neutralizing monoclonal antibody D1. [PDF]

Vet Res
Xiao S, Zhu X, Zheng M, Jiang D, Zheng C, Cheng X, Wang S, You G, Chen S, Chen S.   +9 more
europepmc   +1 more source