Results 331 to 340 of about 554,474 (398)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

OligoDOM^TM: a T-cell response-enhancing platform applied to cancer immunotherapy. [PDF]

Front Immunol
Del Campo J, Valsesia S, Nikly E, Ruiu R, Iacoviello A, Quaglino E, Cavallo F, Hannani D, Boucher E, Nicolas F, Le Vert A, Doro F.   +11 more
europepmc   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

Targeting Bottlenecks in Malaria Transmission: Antibody-Epitope Descriptions Guide the Design of Next-Generation Biomedical Interventions. [PDF]

Immunol Rev
Yoo R, Jore MM, Julien JP.
europepmc   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

A comprehensive strategy for the development of a multi-epitope vaccine targeting <i>Treponema pallidum</i>, utilizing heat shock proteins, encompassing the entire process from vaccine design to <i>in vitro</i> evaluation of immunogenicity. [PDF]

Front Microbiol
Jiang J, Xu L, Wang X, Wang M, Cao Y, Li R, Zheng K, Wu X.   +7 more
europepmc   +1 more source

One Health Approach to the Computational Design of a Lipoprotein-Based Multi-Epitope Vaccine Against Human and Livestock Tuberculosis. [PDF]

Int J Mol Sci
Shey RA, Nchanji GT, Stong TYA, Yaah NE, Shintouo CM, Yengo BN, Nebangwa DN, Efeti MT, Chick JA, Ayuk AB, Gwei KY, Lemoge AA, Vanhamme L, Ghogomu SM, Souopgui J.   +14 more
europepmc   +1 more source

Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8⁺ T cells. [PDF]

Front Microbiol
Ding Y, Yan J, Huang L, Yu J, Wu Y, Shen C, Fang A.   +6 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Development of a Novel mRNA Vaccine Against <i>Shigella</i> Pathotypes Causing Widespread Shigellosis Endemic: An In-Silico Immunoinformatic Approach. [PDF]

Bioinform Biol Insights
Razzak A, Saha O, Sultana KF, Amin MR, Zahid AB, Sultana A, Bristi UP, Rajia S, Sarker N, Rahaman MM, Bahadur NM, Hossen F.   +11 more
europepmc   +1 more source