Results 331 to 340 of about 607,096 (382)
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Annual Review of Genetics, 1998
▪ Abstract Epitope tagging is a recombinant DNA method by which a protein encoded by a cloned gene is made immunoreactive to a known antibody. This review discusses the major advantages and limitations of epitope tagging and describes a number of recent applications.
J W, Jarvik, C A, Telmer
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▪ Abstract Epitope tagging is a recombinant DNA method by which a protein encoded by a cloned gene is made immunoreactive to a known antibody. This review discusses the major advantages and limitations of epitope tagging and describes a number of recent applications.
J W, Jarvik, C A, Telmer
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Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Science, 2009 Damian C Ekiert +2 more
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Proof of principle for epitope-focused vaccine design
Nature, 2014 Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing ...
Bruno Correia +2 more
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ACS Infectious Diseases, 2022
The ongoing coronavirus disease 2019 pandemic has raised concerns about the risk of re-infection. Non-neutralizing epitopes are one of the major reasons for antibody-dependent enhancement. Past studies on the ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have revealed an infectivity-enhancing site on the ancestral SARS-CoV-2 ...
Hua-Rui Gong +5 more
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The ongoing coronavirus disease 2019 pandemic has raised concerns about the risk of re-infection. Non-neutralizing epitopes are one of the major reasons for antibody-dependent enhancement. Past studies on the ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have revealed an infectivity-enhancing site on the ancestral SARS-CoV-2 ...
Hua-Rui Gong +5 more
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Molecular Biotechnology, 1994
Monoclonal antibodies (MAbs) are specific immunological tools because they bind to a precise determinant (the epitope) on the surface of a protein. The procedure of identifying the binding site of a MAb is often termed "epitope mapping."
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Monoclonal antibodies (MAbs) are specific immunological tools because they bind to a precise determinant (the epitope) on the surface of a protein. The procedure of identifying the binding site of a MAb is often termed "epitope mapping."
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A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses
Science, 2011 Damian C Ekiert +2 more
exaly +2 more sources
1998
Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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Autoimmune epitopes: autoepitopes
Autoimmunity Reviews, 2004The identity of reactants for autoantibodies has been successively refined from whole cellular organelles (immunofluorescence), identified molecules (immunoblot; gene expression libraries), epitope regions (truncated cDNAs; peptide scanning) to contact residues, as described here.
Ian R, Mackay, Merrill J, Rowley
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Seminars in Oncology, 2006
Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Sumanta Kumar, Pal, Mark, Pegram
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Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Sumanta Kumar, Pal, Mark, Pegram
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Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies
Advances in Materials, 2019Epitope imprinting is a promising tool to generate antibody‐like specific recognition sites. Recently, because of the ease of obtaining templates, the flexibility in selecting monomers, their resistance to harsh environments, and the high specificity ...
Kaiguang Yang +8 more
semanticscholar +1 more source