Results 381 to 390 of about 554,474 (398)
Some of the next articles are maybe not open access.
1991
By conventional immunological and physicochemical techniques natural allergens have been separated into antigenic and allergenic fractions. During the last years new methodological developments enabled to investigate their structures in detail. The first step was the identification of antigenic and allergenic (IgE-binding) epitopes on these molecules ...
W.-D. Müller +3 more
openaire +2 more sources
By conventional immunological and physicochemical techniques natural allergens have been separated into antigenic and allergenic fractions. During the last years new methodological developments enabled to investigate their structures in detail. The first step was the identification of antigenic and allergenic (IgE-binding) epitopes on these molecules ...
W.-D. Müller +3 more
openaire +2 more sources
T-cell epitopes of aeroallergens
Annals of Allergy, Asthma & Immunology, 2009To describe the current knowledge of the T-cell epitopes of common aeroallergens, how they were discovered, and implications for future therapy.PubMed search of English-language articles without date limits pertaining to T-cell epitopes of aeroallergens included on a standard skin test panel.A total of 127 articles were screened based on the results of
Adrian G. Letz, Christopher W. Calabria
openaire +2 more sources
Prediction of Antibody Epitopes
2015Antibodies recognize their cognate antigens in a precise and effective way. In order to do so, they target regions of the antigenic molecules that have specific features such as large exposed areas, presence of charged or polar atoms, specific secondary structure elements, and lack of similarity to self-proteins.
Morten Nielsen +2 more
openaire +3 more sources
Blood, 2008
To the editor: The FMC7 antibody, originally described in 1981,[1][1] detects an antigen expressed on mature human B cells and is used in immunophenotypic analysis and differential diagnosis of lymphomas and leukemias. The identity of the FMC7 antigen was unclear for many years.
Julie P. Deans, Maria J. Polyak
openaire +3 more sources
To the editor: The FMC7 antibody, originally described in 1981,[1][1] detects an antigen expressed on mature human B cells and is used in immunophenotypic analysis and differential diagnosis of lymphomas and leukemias. The identity of the FMC7 antigen was unclear for many years.
Julie P. Deans, Maria J. Polyak
openaire +3 more sources
An Introduction to Epitope Mapping
2018Antibodies are protein molecules used routinely for therapeutic, diagnostic, and research purposes due to their exquisite ability to selectively recognize and bind a given antigen. The particular area of the antigen recognized by the antibody is called the epitope, and for proteinaceous antigens the epitope can be of complex nature.
Johan Rockberg, Johan Nilvebrant
openaire +2 more sources
2016
The original scientific strategy behind vaccinology has historically been to “isolate, inactivate, and inject,” first invoked by Louis Pasteur. Subsequently, this empirical approach dominated the vaccine development over 80 years. The recombinant DNA technology arised, and in 1980 the first recombinant vaccine against hepatitis B virus was presented ...
openaire +2 more sources
The original scientific strategy behind vaccinology has historically been to “isolate, inactivate, and inject,” first invoked by Louis Pasteur. Subsequently, this empirical approach dominated the vaccine development over 80 years. The recombinant DNA technology arised, and in 1980 the first recombinant vaccine against hepatitis B virus was presented ...
openaire +2 more sources
Current Opinion in Immunology, 1996
Synthetic approaches to T-cell epitope determination have recently been developed that complement the search for natural T-cell epitopes and the investigation of the preferences of the different MHC alleles for particular motifs in cognate peptide sequences. The combination of these different strategies opens new possibilities for basic, as well as for
openaire +3 more sources
Synthetic approaches to T-cell epitope determination have recently been developed that complement the search for natural T-cell epitopes and the investigation of the preferences of the different MHC alleles for particular motifs in cognate peptide sequences. The combination of these different strategies opens new possibilities for basic, as well as for
openaire +3 more sources
2009
The current challenge in synthetic vaccine design is the development of a methodology to identify and test short antigen peptides as potential T cell epitopes. A HLA-peptide binding model (using structural properties) capable of predicting peptides binding to any HLA allele has been described in Chap. 7.
openaire +2 more sources
The current challenge in synthetic vaccine design is the development of a methodology to identify and test short antigen peptides as potential T cell epitopes. A HLA-peptide binding model (using structural properties) capable of predicting peptides binding to any HLA allele has been described in Chap. 7.
openaire +2 more sources
Cryptic epitope and autoimmunity
Diabetes / Metabolism Reviews, 1998Micheal S. Lan, Noel K. Maclaren
openaire +3 more sources