Results 211 to 220 of about 100,019 (301)

Epitope mapping via in vitro deep mutational scanning methods and its applications. [PDF]

J Biol Chem
Keen MM, Keith AD, Ortlund EA.
europepmc   +1 more source

Epitope Mapping of BmpA and BBK32 Borrelia burgdorferi Sensu Stricto Antigens for the Design of Chimeric Proteins with Potential Diagnostic Value. [PDF]

ACS Infect Dis, 2023
Grąźlewska W, Holec-Gąsior L, Sołowińska K, Chmielewski T, Fiecek B, Contreras M.   +5 more
europepmc   +1 more source

Pea and Lentil 7s Globulin Crystal Structures with Comparative Immunoglobulin Epitope Mapping

, 2022
Kelly A. Robinson, Antony D. St‐Jacques, Isabella D. Bakestani, Benjamin A. G. Beavington, Michèle C. Loewen   +4 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Sialic Acid-Binding Protein-1 (SABP1) of <i>Toxoplasma gondii</i>: Preliminary Computer-Based Epitope Mapping for Enhanced Vaccine Design. [PDF]

J Parasitol Res
Gholami S, Abadi AJE, Ghiabi S, Siamian D, Abdollahi H, Famili F, Yousefi A, Majidiani H.   +7 more
europepmc   +1 more source

Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein

, 2017
Ruisong Yu, Rui Zhu, Weixiang Gao, Ming Zhang, Shijuan Dong, Bingqing Chen, Yu Li, Chunfang Xie, Fengying Jiang, Zhen Li   +9 more
openalex   +2 more sources

Production, Characterization, and Epitope Mapping of Monoclonal Antibodies Against Different Subtypes of Rabbit Hemorrhagic Disease Virus (RHDV) [PDF]

, 2016
Desheng Kong, Jiasen Liu, Qian Jiang, Zuo Yu, Xiaoliang Hu, Dongchun Guo, Qianqian Huang, Meihui Jiao, Liandong Qu   +8 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Epitope mapping of a neutralizing antibody against rabbit hemorrhagic disease virus GI.2. [PDF]

Vet Res
Podadera A, Leuthold M, Martín-Alonso JM, Casais R, Álvarez AL, Lobo-Castañón MJ, Parra F, Dalton KP.   +7 more
europepmc   +1 more source