Results 71 to 80 of about 1,474,718 (406)
Mapping epitope characteristics on carcinoembryonic antigen [PDF]
British Journal of Cancer, 1986 A method of epitope analysis is described in which the binding of one monoclonal antibody (MAb) to radiolabeled carcinoembryonic antigen (CEA) competes with the subsequent binding of an immobilised second MAb. From the degree of blocking obtained, we have identified both structurally related and independent epitopes on CEA.
G. M. Boxer +5 more
openaire +3 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Application of NMR Screening Methods with 19F Detection to Fluorinated Compounds Bound to Proteins
Magnetochemistry, 2017 The combinational use of one-dimensional (1D) NMR-based screening techniques with 1H and 19F detections were applied to a human serum albumin–diflunisal complex.
Kazuo Furihata +2 more
doaj +1 more source
A simpler and more cost-effective peptide biosynthetic method using the truncated GST as carrier for epitope mapping. [PDF]
PLoS ONE, 2017 There is a need to develop better methods for epitope mapping and/or identification of antibody-recognizing motifs. Here, we describe improved biosynthetic peptide (BSP) method using a newly developed plasmid pXXGST-3 as vector, which has a viral E7 gene
Wan-Xiang Xu +9 more
doaj +1 more source
Active Learning Framework for Cost-Effective TCR-Epitope Binding Affinity Prediction [PDF]
arXiv, 2023 T cell receptors (TCRs) are critical components of adaptive immune systems, responsible for responding to threats by recognizing epitope sequences presented on host cell surface. Computational prediction of binding affinity between TCRs and epitope sequences using machine/deep learning has attracted intense attention recently.
arxiv
Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice [PDF]
, 1988 Experimental allergic encephalomyelitis (EAE)' is an autoimmune inflammatory demyelinating disease in the central nervous system (CNS) of animals immunized with myelin basic protein (MBP). The disease is directly mediated by Thelper cells that recognize
Ando, Dale G. +5 more
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS
Scientific Reports, 2019 Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous drug candidates recognizing a similar target. Here,
C. Puchades +6 more
semanticscholar +1 more source
Data on the epitope mapping of soybean A2 and A3 glycinin
Data in Brief, 2016 The data information provided in this article relate to our research article “Using patient serum to epitope map soybean glycinins reveals common epitopes shared with many legumes and tree nuts” (Saeed et al., 2016) [1].
Hanaa Saeed +3 more
doaj
PLoS ONE, 2016 Dengue virus (DENV) is a major public health threat worldwide. A key element in protection from dengue fever is the neutralising antibody response. Anti-dengue IgG purified from DENV-2 infected human sera showed reactivity against several peptides when ...
Babu Ramanathan +5 more
doaj +1 more source