Results 51 to 60 of about 96,540 (301)

A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. [PDF]

, 2014
UnlabelledPairing high-throughput sequencing technologies with high-throughput mutagenesis enables genome-wide investigations of pathogenic organisms. Knowledge of the specific functions of protein domains encoded by the genome of the hepatitis C virus ...
Arumugaswami, Vaithilingaraja, Chen, Shu-Hwa, Chen, Zugen, Chu, Virginia, Lin, Chung-Yen, Lo, Hung-Hao, Olson, C Anders, Qi, Hangfei, Remenyi, Roland, Stokelman, Tamar, Su, Sheng-Yao, Sun, Ren, Truong, Shawna, Wu, Nicholas C, Wu, Ting-Ting   +14 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Application of NMR Screening Methods with 19F Detection to Fluorinated Compounds Bound to Proteins

Magnetochemistry, 2017
The combinational use of one-dimensional (1D) NMR-based screening techniques with 1H and 19F detections were applied to a human serum albumin–diflunisal complex.
Kazuo Furihata, Moe Usui, Mitsuru Tashiro   +2 more
doaj   +1 more source

Production, characterization, and epitope mapping of monoclonal antibodies of ribosomal protein S3 (rpS3)

Animal Cells and Systems, 2021
Ribosomal protein S3 (rpS3), a member of 40S small ribosomal subunit, is a multifunctional protein with various extra-ribosomal functions including DNA repair endonuclease activity and is secreted from cancer cells.
Woo-Sung Ahn, Tae-Sung Kim, Yong Jun Park, Young Kwang Park, Hag Dong Kim, Joon Kim   +5 more
doaj   +1 more source

Accurate determination of epitope for antibodies with unknown 3D structures

mAbs, 2021
MAbTope is a docking-based method for the determination of epitopes. It has been used to successfully determine the epitopes of antibodies with known 3D structures.
Shifa Tahir, Thomas Bourquard, Astrid Musnier, Yann Jullian, Yannick Corde, Zakaria Omahdi, Laetitia Mathias, Eric Reiter, Pascale Crépieux, Gilles Bruneau, Anne Poupon   +10 more
doaj   +1 more source

Epitope profiling via mixture modeling of ranked data

, 2014
We propose the use of probability models for ranked data as a useful alternative to a quantitative data analysis to investigate the outcome of bioassay experiments, when the preliminary choice of an appropriate normalization method for the raw numerical ...
Benter, Busse, Caron, Critchlow, Critchlow, Croon, Croon, Dempster, Diaconis, Fligner, Fligner, Fraley, Gabrielli, Gormley, Gormley, Gormley, Gormley, Guiver, Hunter, Hunter, Lange, Lee, Luce, Marden, McLachlan, McLachlan, McNicholas, Murphy, Plackett, Schwarz, Vaida   +30 more
core   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

A simpler and more cost-effective peptide biosynthetic method using the truncated GST as carrier for epitope mapping. [PDF]

PLoS ONE, 2017
There is a need to develop better methods for epitope mapping and/or identification of antibody-recognizing motifs. Here, we describe improved biosynthetic peptide (BSP) method using a newly developed plasmid pXXGST-3 as vector, which has a viral E7 gene
Wan-Xiang Xu, Jian Wang, Hai-Ping Tang, Ling-Han Chen, Wen-Bo Lian, Jian-Min Zhan, Satish K Gupta, Chao-Neng Ji, Shao-Hua Gu, Yi Xie   +9 more
doaj   +1 more source

Computational Structure Prediction for Antibody-Antigen Complexes From Hydrogen-Deuterium Exchange Mass Spectrometry: Challenges and Outlook

Frontiers in Immunology, 2022
Although computational structure prediction has had great successes in recent years, it regularly fails to predict the interactions of large protein complexes with residue-level accuracy, or even the correct orientation of the protein partners.
Minh H. Tran, Minh H. Tran, Minh H. Tran, Clara T. Schoeder, Clara T. Schoeder, Clara T. Schoeder, Kevin L. Schey, Jens Meiler, Jens Meiler, Jens Meiler   +9 more
doaj   +1 more source