Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments [PDF]
, 2019 Despite their phenotypic heterogeneity, most human prion diseases belong to two broadly defined groups: Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSS).
Cali, Ignazio +8 more
core +1 more source
Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]
, 2020 ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco +9 more
core +1 more source
Anti-Ro60 Seropositivity Determines Anti-Ro52 Epitope Mapping in Patients With Systemic Sclerosis
Frontiers in Immunology, 2018 Epitope mapping of anti-Ro52 antibodies (Abs) has been extensively studied in patients with Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE).
Athanasios Gkoutzourelas +10 more
doaj +1 more source
eLife, 2021 Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response.
Adam S Dingens +10 more
doaj +1 more source
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]
, 1989 Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G. +5 more
core +1 more source
Reverse epitope mapping of the E2 glycoprotein in antibody associated hepatitis C virus.
PLoS ONE, 2017 The humoral immune system responds to chronic hepatitis C virus (HCV) infection by producing neutralising antibodies (nAb). In this study we generated three HCV pseudoparticles in which E1E2 glycoprotein sequence was targeted by the host humoral immune ...
Amruta S Naik +8 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 African swine fever virus (ASFV) is a lethal pathogen that causes severe threats to the global swine industry and it has already had catastrophic socio-economic effects. To date, no licensed prophylactic vaccine exists. Limited knowledge exists about the
Jin-xing SONG +10 more
doaj +1 more source
A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes [PDF]
, 1987 We have constructed target cells by cotransfection of the MHC gene Ld and fragments of murine cytomegalovirus (MCMV) DNA coding for nonstructural immediate-early (IE) proteins.
Keil, Günther M. +4 more
core +3 more sources
A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus
Viruses, 2016 Hepatitis E virus (HEV) is one of the viral pathogens causing hepatitis in humans. HEV open reading frame 3 (ORF3) encodes a small multifunctional protein (VP13), which is essential for HEV infection.
Yonglin Yang +5 more
doaj +1 more source
An overview on application of phage display technique in immunological studies
Asian Pacific Journal of Tropical Biomedicine, 2017 Phage display is very strong technique in drug discovery and development. Phage display has many applications in improving the immunological studies. Development of monoclonal antibody, peptides, peptidomimetics and epitope mapping are main application ...
Abbas Rami +4 more
doaj +1 more source