Results 41 to 50 of about 96,540 (301)

Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus [PDF]

, 1987
The murine immediate-early (IE) protein pp89 is a nonstructural virus- encoded phosphoprotein residing in the nucleus of infected cells, where it acts as transcriptional activator.
Bertholet, Christine, Jonjic, Stipan, Koszinowski, Ulrich H., Volkmer, Hansjürgen, Wittek, Riccardo   +4 more
core   +4 more sources

Mapping invisible epitopes by NMR spectroscopy [PDF]

Journal of Biological Chemistry, 2020
Defining discontinuous antigenic epitopes remains a substantial challenge, as exemplified by the case of lipid transfer polyproteins, which are common pollen allergens. Hydrogen/deuterium exchange monitored by NMR can be used to map epitopes onto folded protein surfaces, but only if the complex rapidly dissociates.
Emery T. Usher, Scott A. Showalter
openaire   +2 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Epitope Mapping and Tagging by Recombination PCR Mutagenesis

BioTechniques, 1997
We describe a rapid PCR method that directly inserts an epitope tag into an open reading frame (ORF) to facilitate protein detection. This project was performed within a varicella-zoster virus (VZV) system.
Christopher Hatfield, Karen M. Duus, Douglas H. Jones, Charles Grose   +3 more
doaj   +1 more source

Dengue virus antibody database: Systematically linking serotype-specificity with epitope mapping in dengue virus. [PDF]

PLoS Neglected Tropical Diseases, 2017
BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central ...
Sidhartha Chaudhury, Gregory D Gromowski, Daniel R Ripoll, Ilja V Khavrutskii, Valmik Desai, Anders Wallqvist   +5 more
doaj   +1 more source

Mapping Immunodominant Antibody Epitopes of Abrin [PDF]

Antibodies, 2020
Abrin, a toxin isolated from the seeds of Abrus precatorius (jequirity pea) is considered a biological threat agent by the Center for Disease Control and Prevention. To date, there is no effective postexposure treatment for abrin poisoning, and efforts are being made to develop an efficient vaccine and measures for postexposure therapy. Epitope mapping
Ron Alcalay, Reut Falach, Yoav Gal, Anita Sapoznikov, Tamar Sabo, Chanoch Kronman, Ohad Mazor   +6 more
openaire   +3 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction

Journal of Immunology Research, 2016
Identification of B-cell epitopes is a fundamental step for development of epitope-based vaccines, therapeutic antibodies, and diagnostic tools. Epitope-based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in-
Lenka Potocnakova, Mangesh Bhide, Lucia Borszekova Pulzova   +2 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Structure-based high-throughput epitope analysis of hexon proteins in B and C species human adenoviruses (HAdVs). [PDF]

PLoS ONE, 2012
Human adenoviruses (HAdVs) are the etiologic agent of many human infectious diseases. The existence of at least 54 different serotypes of HAdVs has resulted in difficulties in clinical diagnosis.
Xiao-Hui Yuan, Ying-Chen Wang, Wen-Jing Jin, Bin-Bin Zhao, Cai-Feng Chen, Jian Yang, Jing-Fei Wang, Ying-Ying Guo, Jing-Jun Liu, Ding Zhang, Lu-Lu Gong, You-Wen He   +11 more
doaj   +1 more source