Results 91 to 100 of about 505,722 (385)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Phage Display Detection of Mimotopes that Are Shared Epitopes of Clinically and Epidemiologically Relevant Enterobacteria

Microorganisms, 2020
Background: Escherichia coli and Salmonella are etiologic agents of intestinal infections. A previous study showed the presence of shared epitopes between lipopolysaccharides (LPSs) of E. coli O157 and Salmonella.
Armando Navarro, Delia Licona-Moreno, Alejandro Monsalvo-Reyes, Ulises Hernández-Chiñas, Carlos A. Eslava-Campos   +4 more
doaj   +1 more source

Variants of human chorionic gonadotropin from pregnant women and tumor patients recognized by monoclonal antibodies [PDF]

, 1993
In biological fluids, hCG and its free alpha- (hCG alpha) and beta-subunits (hCG beta), occur in multiple forms. These various forms differ at the molecular level primarily in glycosylation, but also differ in protein backbone modifications corresponding
Berger, Peter, Mann, Klaus, Schwarz, Siegfried, Spöttl, Gerald, Wick, Georg   +4 more
core   +1 more source

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

Nature Communications, 2017
Elicitation of broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal. Native-like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are therefore promising vaccine antigens.
Daniel W. Kulp, J. Steichen, M. Pauthner, Xiaozhen Hu, Torben Schiffner, Alessia Liguori, C. Cottrell, C. Havenar-Daughton, G. Ozorowski, Erik Georgeson, O. Kalyuzhniy, Jordan R. Willis, Michael Kubitz, Yumiko Adachi, Samantha M. Reiss, M. Shin, Natalia de Val, A. Ward, S. Crotty, D. Burton, W. Schief   +20 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

SEMA: Antigen B-cell conformational epitope prediction using deep transfer learning

Frontiers in Immunology, 2022
One of the primary tasks in vaccine design and development of immunotherapeutic drugs is to predict conformational B-cell epitopes corresponding to primary antibody binding sites within the antigen tertiary structure.
Tatiana I. Shashkova, Dmitriy Umerenkov, Mikhail Salnikov, Pavel V. Strashnov, Alina V. Konstantinova, Ivan Lebed, Dmitriy N. Shcherbinin, Marina N. Asatryan, Olga L. Kardymon, Nikita V. Ivanisenko, Nikita V. Ivanisenko   +10 more
doaj   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

Improved method for predicting linear B-cell epitopes

Immunome Research, 2006
BackgroundB-cell epitopes are the sites of molecules that are recognized by antibodies of the immune system. Knowledge of B-cell epitopes may be used in the design of vaccines and diagnostics tests. It is therefore of interest to develop improved methods
J. Larsen, O. Lund, M. Nielsen
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. [PDF]

, 2008
Lipid transfer proteins (LTPs) are the major allergens of Rosaceae fruits in the Mediterranean area. Pru p 3, the LTP and major allergen of peach, is a suitable model for studying food allergy and amino acid sequences related with its IgE-binding ...
Compes, Esther, Cuesta-Herranz, Javier, Díaz Perales, Araceli, Pacios, Luis F., Palacín Gómez, Aranzazu, Salcedo Duran, Gabriel, Sánchez-Monge Laguna de Rins, Rosa, Tordesillas Villuendas, Leticia   +7 more
core   +2 more sources