Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice [PDF]
, 1988 Experimental allergic encephalomyelitis (EAE)' is an autoimmune inflammatory demyelinating disease in the central nervous system (CNS) of animals immunized with myelin basic protein (MBP). The disease is directly mediated by Thelper cells that recognize
Ando, Dale G. +5 more
core +1 more source
The mechanism of humoral immune response to allogeneic organ transplantation
Вестник трансплантологии и искусственных органов, 2017 The problem of antibody-mediated rejection of donor organ remains extremely relevant. The main targets of the antibodies are mainly donor HLA-antigens (Human Leucocyte Antigens), expressed, in particular, by the cells of graft vascular endothelium.
A. S. Berkos, G. V. Nikolaev
doaj +1 more source
Predicting influenza H3N2 vaccine efficacy from evolution of the dominant epitope [PDF]
arXiv, 2018 We predict vaccine efficacy with a measure of antigenic distance between influenza A(H3N2) and candidate vaccine viruses based on amino acid substitutions in the dominant epitopes. In 2016-2017, our model predicts 19% efficacy compared to 20% observed.
arxiv
Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines
Frontiers in Immunology, 2022 Shisong Jiang, Min Gong, Xiao-Ning Xu
doaj +1 more source
Designing a B Cell-Based Vaccine against a Highly Variable Hepatitis C Virus
Frontiers in Microbiology, 2018 The ability to use structure-based design and engineering to control the molecular shape and reactivity of an immunogen to induce protective responses shows great promise, along with corresponding advancements in vaccine testing and evaluation systems ...
Thomas R. Fuerst +5 more
doaj +1 more source
Preliminary assessment of various additives on the specific reactivity of anti- rHBsAg monoclonal antibodies [PDF]
, 2015 Background: Antibodies have a wide application in diagnosis and treatment. In order to maintain optimal stability of various functional parts of antibodies such as antigen binding sites, several approaches have been suggested.
Mohammadi, S. +3 more
core
Localization of epitopes of herpes simplex virus type 1 glycoprotein D [PDF]
, 1985 Roselyn J. Eisenberg +9 more
openalex +1 more source
Frontiers in Fungal BiologyCandida albicans is the predominant cause of systemic candidiasis, although other non albicans Candida species are progressively becoming more widespread nowadays.
Manisha Shukla +4 more
doaj +1 more source
ZIKV Envelope Domain-Specific Antibodies: Production, Purification and Characterization
Viruses, 2019 Infection with Zika virus (ZIKV) came first to public attention after it was found to be associated with congenital microcephaly during the outbreak in Brazil (2015–2016). Diagnosis of ZIKV suffers from extensive cross-reactivity with other Flaviviruses,
Sami Akhras +4 more
doaj +1 more source
AsEP: Benchmarking Deep Learning Methods for Antibody-specific Epitope Prediction [PDF]
arXivEpitope identification is vital for antibody design yet challenging due to the inherent variability in antibodies. While many deep learning methods have been developed for general protein binding site prediction tasks, whether they work for epitope prediction remains an understudied research question.
arxiv