Results 111 to 120 of about 241,882 (308)
Rapid and long-term disappearance of CD4+ T lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A. marginale [PDF]
, 2005 In humans and ruminants infected with Anaplasma, the major surface protein 2 (MSP2) is immunodominant. Numerous CD4(+) T cell epitopes in the hypervariable and conserved regions of MSP2 contribute to this immunodominance.
Abbott, Jeffrey R +7 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Preexisting Immunity to Pandemic (H1N1) 2009
Emerging Infectious Diseases, 2009 Zheng Xing, Carol J. Cardona
doaj +1 more source
, 2017 Peiyang Ding,1,2 Teng Zhang,2,3 Yafei Li,1,2 Man Teng,2 Yaning Sun,2 Xiao Liu,2,4 Shujun Chai,2 Enmin Zhou,1 Qianyue Jin,2,5 Gaiping Zhang1,2,4,5 1College of Veterinary Medicine, Northwest A&F University, Yangling, 2Henan Provincial Key Laboratory ...
Liu X +9 more
core
Epitopes in ChEBI - A Collaboration with the IEDB
, 2010 *ChEBI background:* Chemical Entities of Biological Interest (ChEBI) is a curated database of small chemical entities important in biosystems. As well as a description of entities, it provides a semantically rich knowledge base; and an internal hierarchy
Marcus Ennis +6 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
As entropic epitopes escape, the CD8 T cell responses specific for these epitopes wane.
, 2015 (A) The four immunodominant epitopes from all animals were plotted according to their entropies and whether they escaped the CD8 T cell response. Anentropic epitopes demonstrated significantly less escape than highly entropic epitopes.
Fay E. Wong (693012) +10 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 2014 Citation: 'epitope' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E02171 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial usage
openaire +1 more source