Results 131 to 140 of about 241,882 (308)

Capturing virus evolution by proteomic bioinformatics: Hunting for characteristic mutations in the hepatitis E virus genome

Virulence, 2018
Dominik Harms, Bo Wang, C. Patrick Papp, C.-Thomas Bock   +3 more
doaj   +1 more source

A Native Mass Spectrometry Approach to Qualitatively Elucidate Interfacial Epitopes of Transient Protein-Protein Interactions

Native mass spectrometric analysis of TPR2A and GrpE with unpurified peptides derived from limited proteolysis of their respective PPI partners (HSP90 C-terminus and DnaK) facilitated efficient, qualitative identification of interfacial epitopes involved
Fernando, Albericio, Clinton, Veale, Beatriz, de la Torre, Adrienne, Edkins, Abir, Chakraborty, Richwell, Mhlanga, David, Clarke   +6 more
core   +1 more source

Epitopes vary in similarity to microbiome sequences.

, 2018
Epitope and non-epitope median BLOSUM scores for (A) Allergy, (B) Autoimmunity, (C) Virus, and (D) Bacteria categories. Blue dots indicate non-epitopes being less conserved in the human microbiome, red dots when epitopes are less conserved and black dots
Sebastian Carrasco Pro (5180867), Mikaela Lindvall (4012100), Clark A. Santee (5180873), Cecilia S. Lindestam Arlehamn (179138), Bjoern Peters (19131), Ali A. Faruqi (5180864), John Sidney (19127), Harald Renz (511614), Sandeep K. Dhanda (5180870), Chelsea Carpenter (2878637), Alessandro Sette (19132)   +10 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1

, 2012
HLA class I-associated polymorphisms identified at the population level mark viral sites under immune pressure by individual HLA alleles. As such, analysis of their distribution, frequency, location, statistical strength, sequence conservation, and other
Nelson, G., Carrington, M., Haubrich, R., Knapp, D.J.H.F., DeZiel, C.E., John, M., Brumme, Z.L., Carlson, J.M., Brumme, C.J., Listgarten, J., Riddler, S.A., Pfeifer, N., Apps, R., Harrigan, P.R., Heckerman, D., Le, A.Q., Cotton, L.A., Martin, E., Chui, C.K.S., Brockman, M.A., Mallal, S.   +20 more
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Epitope-based therapeutic targets in HCV genotype 1 non-structural proteins: a novel strategy to combat emerging drug resistance

Frontiers in Cellular and Infection Microbiology
IntroductionThe hepatitis C virus (HCV) poses a major global health challenge, with its non-structural proteins being essential for viral replication and pathogenesis. Mutations in these proteins significantly contribute to drug resistance, necessitating
Mireayi Tudi, Adili Sawuti, Maimaitituerhong Abudurusuli, Chao Wu, Xiaoyu Chen, Gulimire Ailimu, Kuerbannisa Wulayin, Maimaitiaili Tuerxun   +7 more
doaj   +1 more source

Identification of epitopes on the Dengue virus type 4 envelope glycoprotein involved in neutralisation by antibodies

, 2006
Dengue virus (DENV) is the causative agent of dengue fever (DF), the most prevalent arthropod-borne viral disease in the world and therefore is considered an emerging global health threat. The four DENV serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) that
Howard, Christopher Bruce
core  

CTL induction by cross-priming is restricted to immunodominant epitopes

, 2009
CTL are induced by two pathways, i.e. direct priming, where tumor cells present tumor antigens to naïve specific CTL, and cross-priming, where professional APC cross-present captured tumor antigens to CTL.
Mumprecht, Sabine, Breyer, Isabel, Pavelic, Viktor, Isabel Breyer, Sabine Mumprecht, Matter, Matthias S, Matthias S. Matter, Viktor Pavelic, Ochsenbein, Adrian F, Adrian F. Ochsenbein   +9 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source