Results 141 to 150 of about 258,671 (306)

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection [PDF]

, 2008
During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely characterized.
Carrington, M., Brumme, Z. L., John, M., Altfeld, M., Streeck, H., Markowitz, M., Block, B. L., Kaldor, J., Heckerman, D., Kelleher, A. D., Carlson, J., Jessen, H., Kadie, C., Yuki, Y., Rosenberg, E., Walker, B. D., Eichbaum, Q., Baker, B., Allen, T. M., Brumme, C. J., Mallal, S.   +20 more
core  

A novel multi-epitope mRNA vaccine against colorectal cancer: in silico design and immune efficacy profiling

Frontiers in Immunology
BackgroundColorectal cancer (CRC) has emerged as a growing global health challenge, while immunotherapy, particularly mRNA-based cancer vaccines, has emerged as a promising approach due to its ability to induce targeted immune responses with minimal ...
Lin Wang, Lin Wang, Xiaofei Zhou, Yu Wei, Jianping Lin, Jianping Lin   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Capturing virus evolution by proteomic bioinformatics: Hunting for characteristic mutations in the hepatitis E virus genome

Virulence, 2018
Dominik Harms, Bo Wang, C. Patrick Papp, C.-Thomas Bock   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Epitopes vary in similarity to microbiome sequences.

, 2018
Epitope and non-epitope median BLOSUM scores for (A) Allergy, (B) Autoimmunity, (C) Virus, and (D) Bacteria categories. Blue dots indicate non-epitopes being less conserved in the human microbiome, red dots when epitopes are less conserved and black dots
Sebastian Carrasco Pro (5180867), Mikaela Lindvall (4012100), Clark A. Santee (5180873), Cecilia S. Lindestam Arlehamn (179138), Bjoern Peters (19131), Ali A. Faruqi (5180864), John Sidney (19127), Harald Renz (511614), Sandeep K. Dhanda (5180870), Chelsea Carpenter (2878637), Alessandro Sette (19132)   +10 more
core   +1 more source

Structural and Spatial Analysis of The Recognition Relationship Between Influenza A Virus Neuraminidase Antigenic Epitopes and Antibodies

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveThis study leverages structural data from antigen-antibody complexes of the influenza A virus neuraminidase (NA) protein to investigate the spatial recognition relationship between the antigenic epitopes and antibody paratopes.MethodsStructural ...
ZHU Zheng, CHEN Zheng-Shan, ZHANG Guan-Ying, FANG Ting, FAN Pu, BI Lei, CUI Yue, LI Ze-Ya, SU Chun-Yi, CHI Xiang-Yang, YU Chang-Ming   +10 more
doaj   +1 more source