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T-Cell Epitope Processing (The Epitope Flanking Regions Matter)
2009Epitopes presented by major histocompatibility complex (MHC) class I molecules for cytotoxic T-lymphocyte (CTL) recognition are derived mainly from cytosolic proteins. Antigen presentation on the cell surface requires correct processing of epitopes by the proteasome, cytosolic and endoplasmic reticulum (ER) aminopeptidases, efficient TAP transport, and
Alejandra Nacarino, Martinez +2 more
openaire +2 more sources
2000
Abstract The previous two chapters described antigenic variation in a single epitope. In this chapter we develop mathematical models of antigenic variation in multiple epitopes. The resulting ‘Multiple epitope theory’ leads to significant refinements in our understanding of the dynamical interaction between genetically variable ...
Martin A Nowak, Robert M May
openaire +1 more source
Abstract The previous two chapters described antigenic variation in a single epitope. In this chapter we develop mathematical models of antigenic variation in multiple epitopes. The resulting ‘Multiple epitope theory’ leads to significant refinements in our understanding of the dynamical interaction between genetically variable ...
Martin A Nowak, Robert M May
openaire +1 more source

