Results 251 to 260 of about 228,208 (297)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

SARS-CoV-2 Spike Protein and Molecular Mimicry: An Immunoinformatic Screen for Cross-Reactive Autoantigen Candidates. [PDF]

Int J Mol Sci
Timofeeva AM, Aulova KS, Mustaev EA, Nevinsky GA.   +3 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Conserved multiepitopes in <i>Plasmodium falciparum</i> STEVORs enable rational design of a fusion antigen vaccine construct with broad immunogenicity. [PDF]

Emerg Microbes Infect
Sun ZS, Yin JX, Zhao HQ, Zhu YS, Chen SB, Shen HM, Xu B, Zhou XN, Wang TY, Yang WX, Duan YW, Chen JH, Kassegne K.   +12 more
europepmc   +1 more source

Identification of linear B-cell epitopes on the gE envelope protein of varicella-zoster virus. [PDF]

Microbiol Spectr
Niu Y, Zhou J, Liu Y, Wang H, Liu H, Chen Y, Zhu X, Liang C, Wang A.   +8 more
europepmc   +1 more source

Molecular Insights into Tumor Immunogenicity. [PDF]

Curr Issues Mol Biol
Doytchinova I, Sotirov S, Dimitrov I.
europepmc   +1 more source

Immunoinformatic design of chimeric multiepitope vaccine for the prevention of human metapneumovirus (hMPV). [PDF]

BMC Infect Dis
Ehsasatvatan M, Kohnehrouz BB, Salavatizadeh M.   +2 more
europepmc   +1 more source

Phage-display immunoprecipitation sequencing reveals distinct antibody repertoire patterns across a rural-urban gradient

Laidlaw RF, Innocenti G, Vogl T, Mbow M, Yazdanbakhsh M, Manurung MD.   +5 more
europepmc   +1 more source

Viral Diversity Influences T Cell Responses to Enteric Human Adenoviruses F40 and F41

Craven HM, Hoang JP, Mukhopadhyay R, Lambisia AW, Krishna BAC, Ravenhill BJ, Agoti CN, Houldcroft CJ.   +7 more
europepmc   +1 more source