Results 61 to 70 of about 505,722 (385)

Large Scale Genome Analysis Shows that the Epitopes for Broadly Cross-Reactive Antibodies Are Predominant in the Pandemic 2009 Influenza Virus A H1N1 Strain

Viruses, 2013
The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal influenza viruses. It has changed the pre-existing immunity of the human population to succeeding infections.
Edgar E. Lara-Ramírez, Aldo Segura-Cabrera, Ma Isabel Salazar, Mario A. Rodríguez-Pérez, Xianwu Guo   +4 more
doaj   +1 more source

Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas

Viruses, 2022
The causal relationship between HPV and cervical cancer in association with the high prevalence of high risk HPV genotypes led to the design of HPV vaccines based on the major capsid L1 protein.
Dimitris Tsakogiannis, Marios Nikolaidis, Flora Zagouri, Eleni Zografos, Christine Kottaridi, Zaharoula Kyriakopoulou, Lamprini Tzioga, Panayotis Markoulatos, Grigoris D. Amoutzias, Garyfalia Bletsa   +9 more
doaj   +1 more source

Innate sensing of oxidation-specific epitopes in health and disease

Nature reviews. Immunology, 2016
Ageing, infections and inflammation result in oxidative stress that can irreversibly damage cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of these deleterious consequences that not only alters lipid function but ...
C. Binder, N. Papac-Miličević, J. Witztum   +2 more
semanticscholar   +1 more source

epiArt: a graphical HLA eplet amino acid repertoire translation reveals the need for an epitope driven revision of allele group nomenclature

Frontiers in Genetics
IntroductionThe immune response after transplantation depends on recipient/donor HLA allele mismatches. To enhance our understanding of the relations of HLA alleles in terms of amino-acid polymorphisms and shared epitopes, we assessed pairwise sequence ...
Ilias Doxiadis, Claudia Lehmann, Nils Lachmann, Henry Loeffler-Wirth   +3 more
doaj   +1 more source

Seeking Flavivirus Cross-Protective Immunity

Frontiers in Immunology, 2019
The Flavivirus genus is composed by viral serocomplexes with relevant global epidemiological impact. Many areas of the world present both, vector fauna and geographical conditions compatible with co-circulation, importing, emergence, and epidemics of ...
Lorrany dos Santos Franco, Letícia Tsieme Gushi, Wilson Barros Luiz, Jaime Henrique Amorim, Jaime Henrique Amorim   +4 more
doaj   +1 more source

Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources

ElliPro: a new structure-based tool for the prediction of antibody epitopes

BMC Bioinformatics, 2008
BackgroundReliable prediction of antibody, or B-cell, epitopes remains challenging yet highly desirable for the design of vaccines and immunodiagnostics.
Julia V. Ponomarenko, H. Bui, Wei Li, Nicholas Fusseder, Philip E. Bourne, Alessandro Sette, Björn Peters   +6 more
semanticscholar   +1 more source

Comprehensive Overview of Broadly Neutralizing Antibodies against SARS-CoV-2 Variants

Viruses
Currently, SARS-CoV-2 has evolved into various variants, including the numerous highly mutated Omicron sub-lineages, significantly increasing immune evasion ability. The development raises concerns about the possibly diminished effectiveness of available
Lingyan Cui, Tingting Li, Wenhui Xue, Sibo Zhang, Hong Wang, Hongjing Liu, Ying Gu, Ningshao Xia, Shaowei Li   +8 more
doaj   +1 more source

Identification of B-Cell Epitopes with Potential to Serologicaly Discrimnate Dengue from Zika Infections

Viruses, 2019
Dengue is currently one of the most important arbovirus infections worldwide. Early diagnosis is important for disease outcome, particularly for those afflicted with the severe forms of infection.
Alice F. Versiani, Raissa Prado Rocha, Tiago A. O. Mendes, Glauco C. Pereira, Jordana Graziella A. Coelho dos Reis, Daniella C. Bartholomeu, Flávio G. da Fonseca   +6 more
doaj   +1 more source

A vaccine formulated with the major outer membrane protein can protect C3H/HeN, a highly susceptible strain of mice, from a Chlamydia muridarum genital challenge. [PDF]

, 2015
C3H/HeN female mice were vaccinated with native Chlamydia muridarum major outer membrane protein (MOMP), using Montanide+CpG or Alum+CpG as adjuvants. Negative control groups were immunized with ovalbumin (OVA) and the same adjuvants. As positive control,
de la Maza, Luis M, Pal, Sukumar, Tatarenkova, Olga V   +2 more
core   +1 more source