Results 121 to 130 of about 5,392 (239)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, Volume 599, Issue 22, Page 3244-3280, November 2025.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Clinical Perspectives in Epitranscriptomics
Current Opinion in Genetics & DevelopmentEpitranscriptomics, the study of reversible and dynamic chemical marks on the RNA, is rapidly emerging as a pivotal field in post-transcriptional gene expression regulation. Increasing knowledge about epitranscriptomic landscapes implicated in disease pathogenesis proves an invaluable opportunity for the identification of epitranscriptomic biomarkers ...
Eloy Santos-Pujol +2 more
openaire +2 more sources
Analysis of bacterial transcriptome and epitranscriptome using nanopore direct RNA sequencing
Nucleic Acids ResearchBacterial gene expression is a complex process involving extensive regulatory mechanisms. Along with growing interests in this field, Nanopore Direct RNA Sequencing (DRS) provides a promising platform for rapid and comprehensive characterization of ...
Lu Tan +7 more
semanticscholar +1 more source
Epitranscriptomic RNA Methylation in Plant Development and Abiotic Stress Responses
Frontiers in Plant Science, 2019 Recent advances in methylated RNA immunoprecipitation followed by sequencing and mass spectrometry have revealed widespread chemical modifications on mRNAs.
Jianzhong Hu +2 more
doaj +1 more source
Elucidation of the Epitranscriptomic RNA Modification Landscape of Chikungunya Virus
VirusesThe genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral
Belinda Baquero-Pérez +7 more
doaj +1 more source
Nature CommunicationsRNAs are often modified to invoke new activities. While many modifications are limited in frequency, restricted to non-coding RNAs, or present only in select organisms, 5-methylcytidine (m5C) is abundant across diverse RNAs and fitness-relevant across ...
K. Fluke +12 more
semanticscholar +1 more source
Mettl1-dependent tRNA m7G modification controls tRNA expression and fertility in Drosophila melanogaster [PDF]
, 2023 総合研究大学院大学博士（理学）application ...
12275 +5 more
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Introduction to ‘The Epitranscriptome’
RSC Chemical BiologyRalph Kleiner (Princeton University, USA), Claudia Höbartner (University of Würzburg, Germany) and Guifang Jia (Peking University, China) introduce the themed collection on ‘The Epitranscriptome’.
Kleiner, Ralph E. +2 more
openaire +2 more sources
The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression
MedCommRNA modification has emerged as a crucial area of research in epigenetics, significantly influencing tumor biology by regulating RNA metabolism. N‐acetyltransferase 10 (NAT10)‐mediated N4‐acetylcytidine (ac4C) modification, the sole known acetylation in ...
Zhuoran Gu +14 more
doaj +1 more source