Results 11 to 20 of about 14,325 (202)

Influence of combined eplerenone, aflibercept and nepafenac therapy on central serous chorioretinopathy. [PDF]

Int J Ophthalmol
Ewais WA, Samy Ali L, Aboalazayem F.
europepmc   +2 more sources

UNI-494 treatment improves measures of renal dysfunction and cardiac pathology in male rats receiving L-NAME and angiotensin II. [PDF]

Physiol Rep
Abstract Mitochondrial dysfunction is essential in the pathophysiology of both cardiovascular disease (CVD) and chronic kidney disease (CKD). Nicorandil, a nicotinamide nitrate derivative, has been used for years as a cardioprotective agent. It binds to sulfonylurea receptors, activating mitochondrial ATP‐sensitive potassium channels (MitoKATP) and ...
Ho FJM, Siow CJR, Aljaibeji H, Ding M, Mitchell RN, Medicherla S, Reddy G, Gupta S, Williams GH, Romero JR.   +9 more
europepmc   +2 more sources

Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study [PDF]

, 2018
Objective: Aldosterone stimulates cardiac collagen synthesis. Circulating biomarkers of collagen turnover provide a useful tool for the assessment of cardiac remodeling in patients with an acute myocardial infarction (MI).
A Struthers, AH Ellims, AS Levey, B Lopez, B Lopez, Bertram Pitt, Christian W. Hamm, CS Cook, D Buckert, D Quilliot, Esteban Lopez de Sa, Eva Turgonyi, F Azibani, F Beygui, F Zannad, F Zannad, Faiez Zannad, Freek Verheugt, G Condorelli, G Klappacher, G Montalescot, Gilles Montalescot, H Izawa, Harry Shi, John Vincent, João Pedro Ferreira, JP Ferreira, Kévin Duarte, M Gyongyosi, M Hayashi, Marcus Flather, Miguel Orri, O Huttin, P Uusimaa, Patrick Rossignol, PS Jhund, V Krizhanovsky, W Iraqi, Y Sun, YH Lin   +39 more
core   +16 more sources

A Prospective Study of Eplerenone in the Treatment of Patients with Glomerulonephritis

Biomedicines, 2023
Background: High aldosterone levels contribute to kidney disease progression, while spironolactone in combination with ACEi or ARBs can potentially reduce proteinuria and ameliorate kidney function deterioration.
Marios Papasotiriou, Georgia Andrianna Georgopoulou, Adamantia Mpratsiakou, Theodoros Ntrinias, Georgios Lyras, Dimitrios S. Goumenos, Evangelos Papachristou   +6 more
doaj   +1 more source

Bilateral bullous central serous chorioretinopathy treated with PDT and eplerenone

American Journal of Ophthalmology Case Reports, 2022
Purpose: To report a case evaluating PDT and eplerenone therapy in a patient with bilateral bullous central serous chorioretinopathy. Observations: A 30-year-old male was referred for worsening bilateral bullous central serous chorioretinopathy (bCSCR ...
William J. Anderson, Bradley T. Smith
doaj   +1 more source

Effect of Eplerenone, a Selective Aldosterone Blocker, on the Development of Diabetic Nephropathy in Type 2 Diabetic Rats [PDF]

Diabetes & Metabolism Journal, 2012
BackgroundAldosterone antagonists are reported to have beneficial effects on diabetic nephropathy by effective blocking of the renin-angiotensin-aldosterone system.
Jae Hee Ahn, Ho Cheol Hong, Myong Jin Cho, Yoon Jung Kim, Hae Yoon Choi, Chai Ryoung Eun, Sae Jeong Yang, Hye Jin Yoo, Hee Young Kim, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim   +14 more
doaj   +1 more source

The role of free radical oxidation in the kidneys in the nephroprotective action of eplerenone, a mineralocorticoid receptor antagonist, in experimental diabetes mellitus

Бюллетень сибирской медицины, 2021
Aim. To study the effect of eplerenone on the activity of free radical oxidation and renal function in rats with experimental diabetes mellitus induced by streptozotocin.Materials and methods. Experiments were carried out on 36 male Wistar rats. Diabetes
A. Yu. Zharikov, S. O. Filinova, O. N. Mazko, O. G. Makarova, I. P. Bobrov, V. M. Bryukhanov   +5 more
doaj   +1 more source

Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure [PDF]

, 2020
Aims Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis.
Anker, Stefan D., Dickstein, Kenneth, Duarte, Kevin, Ferreira, Joao Pedro, Girerd, Nicolas, Kobayashi, Masatake, Lamiral, Zohra, Lang, Chim C., Metra, Macro, Ng, Leong L., Preud'homme, Gregoire, Rossignol, Patrick, Samani, Nilesh J., Stienen, Susan, ter Maaten, Jozine M., van Veldhuisen, Dirk J., Voors, Adriaan A., Zannad, Faiez   +17 more
core   +4 more sources

Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats

Clinical and Experimental Hypertension, 2020
Evidence indicates that renin-angiotensin-aldosterone system (RAS) inhibitors can protect the brain in Alzheimer’s disease and Parkinson’s disease.
Xue Wang, Yuhai Zhu, Shuanglin Wang, Zhuoqun Wang, Haonan Sun, Yujie He, Wei Yao   +6 more
doaj   +1 more source

Possible dose-dependent effect of eplerenone on intraocular pressure

Indian Journal of Ophthalmology, 2023
Purpose: Intraocular pressure (IOP) is the main modifiable risk factor for glaucoma. Current therapies target the anterior outflow of aqueous humor or its production. This study aims to demonstrate eplerenone could reduce IOP through a possible posterior
Seyedeh Mehrsa Sadat Razavi, Ramin Daneshvar   +1 more
doaj   +1 more source