Results 11 to 20 of about 15,072 (244)

A Prospective Crossover Clinical Trial of Esaxerenone and Eplerenone in Patients with Chronic Heart Failure Complicated by Hypertension. [PDF]

Life (Basel)
Esaxerenone, which blocks aldosterone binding, is approved to treat hypertension but not heart failure. We aimed to understand esaxerenone’s efficacy in treating chronic heart failure.
Sezai A, Abe M, Maruyama T, Taoka M, Sekino H, Tanaka M.   +5 more
europepmc   +2 more sources

Postpartum administration of eplerenone to mitigate vascular dysfunction in mice following a preeclampsia-like pregnancy. [PDF]

Sci Rep
Preeclampsia is a severe pregnancy complication associated with substantial injury to systemic vasculature, major organs, and the feto-placental unit, with an approximate mortality rate of 76,000 pregnant women and 500,000 babies each year.
Binder NK, de Alwis N, Beard S, Fato BR, Garg A, Baird L, Young MJ, Hannan NJ.   +7 more
europepmc   +2 more sources

Drug-Resistant Sinus Tachycardia as a Dose-Dependent Side Effect of Spironolactone: A Case Report and Review of the Literature. [PDF]

Clin Case Rep
ABSTRACT Spironolactone is widely used for polycystic ovarian syndrome due to its anti‐androgenic properties. However, rare cardiovascular side effects may occur even in normotensive patients. We report a case of severe palpitations and drug‐resistant sinus tachycardia following high‐dose therapy, emphasizing the need for cautious titration and cardiac
Abdi Z, Chenaghlou M, Rezabakhsh A, Hooshmand Gharabagh L.   +3 more
europepmc   +2 more sources

Eplerenone [PDF]

Nature Reviews Drug Discovery, 2003
Data from animal studies and clinical trials indicate that aldosterone causes cardiovascular and renal injury through mineralocorticoid receptor–dependent mechanisms. However, although aldosterone receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of the nonspecific ...
Ruth, Brown, Jeremy, Quirk, Peter, Kirkpatrick   +2 more
openaire   +4 more sources

A Prospective Study of Eplerenone in the Treatment of Patients with Glomerulonephritis

Biomedicines, 2023
Background: High aldosterone levels contribute to kidney disease progression, while spironolactone in combination with ACEi or ARBs can potentially reduce proteinuria and ameliorate kidney function deterioration.
Marios Papasotiriou, Georgia Andrianna Georgopoulou, Adamantia Mpratsiakou, Theodoros Ntrinias, Georgios Lyras, Dimitrios S. Goumenos, Evangelos Papachristou   +6 more
doaj   +1 more source

Real-world practice patterns of eplerenone use for central serous chorioretinopathy

International Journal of Retina and Vitreous, 2023
Purpose To report eplerenone use by retina specialists worldwide for central serous chorioretinopathy (CSCR). Methods A self-reporting questionnaire was distributed to retina specialists worldwide to gather clinicians’ perspectives on CSCR cases treated,
Ramesh Venkatesh, Vishma Prabhu, Aishwarya Joshi, Rubble Mangla, Rishi Singh, Lihteh Wu, Paolo Lanzetta, Baruch Kuppermann, Francesco Bandello, Francine Behar Cohen, Jay Chhablani   +10 more
doaj   +1 more source

Bilateral bullous central serous chorioretinopathy treated with PDT and eplerenone

American Journal of Ophthalmology Case Reports, 2022
Purpose: To report a case evaluating PDT and eplerenone therapy in a patient with bilateral bullous central serous chorioretinopathy. Observations: A 30-year-old male was referred for worsening bilateral bullous central serous chorioretinopathy (bCSCR ...
William J. Anderson, Bradley T. Smith
doaj   +1 more source

Diabetic kidney disease, biomarkers, and finerenone. [PDF]

Diabetes Obes Metab
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Verma A, Upadhyay A.
europepmc   +2 more sources

Short-term comparison between navigated subthreshold microsecond pulse laser and oral eplerenone for chronic central serous chorioretinopathy

Scientific Reports, 2022
To compare the anatomical/functional changes after navigated subthreshold pulse laser (SML) and oral eplerenone therapy for chronic central serous chorioretinopathy (cCSC). A total of 36 eyes of 36 patients suffering from cCSC treated with navigated SML (
Lisa Toto, Rossella D’Aloisio, Chiara De Nicola, Federica Evangelista, Maria Ludovica Ruggeri, Luca Cerino, Maria Beatrice Simonelli, Agbéanda Aharrh-Gnama, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua   +10 more
doaj   +1 more source

Effect of Eplerenone, a Selective Aldosterone Blocker, on the Development of Diabetic Nephropathy in Type 2 Diabetic Rats [PDF]

Diabetes & Metabolism Journal, 2012
BackgroundAldosterone antagonists are reported to have beneficial effects on diabetic nephropathy by effective blocking of the renin-angiotensin-aldosterone system.
Jae Hee Ahn, Ho Cheol Hong, Myong Jin Cho, Yoon Jung Kim, Hae Yoon Choi, Chai Ryoung Eun, Sae Jeong Yang, Hye Jin Yoo, Hee Young Kim, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim   +14 more
doaj   +1 more source