Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis [PDF]
, 2017 Aims: We questioned whether aldosterone and oxidative stress play a role in vascular damage in severe hypertension and investigated the role of Nox1 in this process.
Ceravolo, Graziela +7 more
core +1 more source
International Journal of Hypertension, 2016 Prospective postmarketing surveillance of Selara (eplerenone), a selective mineralocorticoid receptor antagonist, was performed to confirm its safety and efficacy for hypertension treatment in Japan.
Shoko Takahashi +6 more
doaj +1 more source
Eplerenone in the treatment of central serous chorioretinopathy: a review of the literature
International Journal of Retina and Vitreous, 2018 Purpose The purpose of this review is to examine the role of eplerenone in the treatment of central serous chorioretinopathy (CSCR). Methods A comprehensive search of the PubMed database has been conducted regarding eplerenone for CSCR, while studies ...
Irini Chatziralli +6 more
doaj +1 more source
Baseline characteristics and treatment of patients in prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF) [PDF]
, 2014 Aim<p></p> To describe the baseline characteristics and treatment of the patients randomized in the PARADIGM-HF (Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in Heart Failure) trial, testing ...
Adel R. Rizkala +11 more
core +3 more sources
Oral Mineralocorticoid-Receptor Antagonists: Real-Life Experience in Clinical Subtypes of Nonresolving Central Serous Chorioretinopathy With Chronic Epitheliopathy. [PDF]
, 2016 PURPOSE: To evaluate the efficacy and safety of oral mineralocorticoid-receptor antagonist (MRa) therapy in three clinical presentations of nonresolving central serous chorioretinopathy (CSCR) with chronic epitheliopathy.
Behar-Cohen, F. +6 more
core +1 more source
Effect of eplerenone in percutaneous coronary intervention‐treated post‐myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPHESUS trial [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107536/1/ejhf88 ...
Amano +27 more
core +2 more sources
Pharmacokinetic study of eplerenone in rats after long-term coadministration with buckwheat tea
Kaohsiung Journal of Medical Sciences, 2016 The aim of this study was to investigate the effect of long-term intake of Tartary buckwheat tea on the pharmacokinetics (PK) of eplerenone in rats. A validated high-performance liquid chromatography-mass spectrometry (HPLC-MS) method was established to ...
Liang Zou +7 more
doaj +1 more source
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Aortic regurgitation (AR) develops in up to 25%−30% of patients with left ventricular assist device (LVAD). Treatment remains challenging since surgery confers significant peri‐operative risk and the lack of valvular calcification renders transfemoral transcatheter aortic valve implantation (TF‐TAVI) with non‐dedicated devices technically ...
Daniel Tai‐Leung Chan +9 more
wiley +1 more source
Cardiovascular Diabetology, 2011 Background Aldosterone levels are elevated in a rat model of type 2 diabetes mellitus, the Zucker Diabetic fatty rat (ZDF). Moreover blood pressure in ZDF rats is salt-sensitive.
Brunner Sabine +12 more
doaj +1 more source