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Estimation of Epoxides

Nature, 1949
EPOXIDES occur among the products of the autoxidation of unsaturated fatty acids1 and drying oils2, and it has been suggested that they may be formed as intermediates in certain biological oxidations. Their accurate estimation is therefore a matter of considerable importance.
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The epoxide of carbamazepine.

Clinical and experimental neurology, 1979
Simultaneous steady-state plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide have been measured by high pressure liquid chromatography in 101 epileptic children and adults taking the drug. There was either no statistically significant correlation, or only a very poor correlation, between drug dose and steady-state plasma levels of a)
McKauge, L., Tyrer, J. H., Eadie, M. J.
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Epoxidation

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
R. A. Sheldon, M. C. A. Van Vliet
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Halogenated epoxides and related compounds as inhibitors of epoxide hydrase

Archives of Biochemistry and Biophysics, 1980
Abstract A variety of chlorinated and fluorinated epoxides and related compounds were synthesized and evaluated as inhibitors of epoxide hydrase. The compounds were tested using chicken liver microsomes and a radiometric assay based on [ 3 H]styrene oxide, and using partially purified chicken liver microsomal epoxide hydrase and a continuous ...
R P, Hanzlik, J S, Walsh
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Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide

Experientia, 1977
Cyproheptadine epoxide is a competitive inhibitor or rat liver microsomal epoxide hydrase with an apparent K1-value of 0.75 mM. Cyclobenzaprine and its epoxide stimulate in vitro the activity of this enzyme, whereas cyproheptadine, carbamazepine and carbamazepine epoxide have no effect.
J, Pachecka   +5 more
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Vitamin K epoxide reductase activity in the metabolism of epoxides

Biochemical Pharmacology, 1985
The importance of vitamin K epoxide reductase for the metabolism of a range of structurally diverse epoxides has been investigated. Vitamin K1 epoxide is reduced by rat liver microsomes at a rate of 0.47 nmoles/g liver/min. The rate of menadione oxide reduction is not significantly higher than the non-enzymatic reduction rate.
I, Liptay-Reuter   +4 more
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Aliphatic Epoxide Carboxylation

Annual Review of Biochemistry, 2003
▪ Abstract  Aliphatic epoxides (epoxyalkanes) are highly reactive electrophilic molecules that are formed from the monooxygenase-catalyzed epoxidation of aliphatic alkenes. The bacterial metabolism of short-chain epoxyalkanes occurs by a three-step pathway resulting in net carboxylation to β-ketoacids.
Scott A, Ensign, Jeffrey R, Allen
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Reaction of bromo epoxides and acetoxy epoxides with amines

The Journal of Organic Chemistry, 1967
A, Hassner, P, Catsoulacos
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Attempted cyclization of an epoxide. Elimination of an epoxide

The Journal of Organic Chemistry, 1982
Irvin Rothberg   +3 more
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Precisely Engineered Supported Gold Clusters as a Stable Catalyst for Propylene Epoxidation

Angewandte Chemie - International Edition, 2021
Nidhi Kapil   +2 more
exaly  

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