Results 61 to 70 of about 67,475 (292)

Copper‐Catalyzed Three‐Component Selective 1,4‐Amino Oxygenation of 1,3‐Dienes

Angewandte Chemie, EarlyView.
Enclosed is a copper‐catalyzed selective 1,4‐amino oxgenation of 1,3‐dienes with the presence of a strong Brønsted acid. This three‐component transformation offers a novel and powerful approach to construct (E)‐1,4‐allylic amino oxygenated motifs by the simultaneous installation of structurally diverse alkylamines and alcohols directly onto 1,3‐dienes.
Guangshou Feng, Maria K. Velopolcek, Qiu Wang   +2 more
wiley   +2 more sources

Alternating Copolymerization of Epoxides and Isothiocyanates to Diverse Functional Polythioimidocarbonates and Related Block Polymers^† [PDF]

, 2023
Xiao‐Feng Zhu, Xinyu Lu, Cheng‐Kai Xu, Yu‐Bo Fang, Guan‐Wen Yang, Wei Li, Jingdai Wang, Guang‐Peng Wu   +7 more
openalex   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Chemo-Enzymatic Synthesis of Chiral Epoxides Ethyl and Methyl (S)-3-(Oxiran-2-yl)propanoates from Renewable Levoglucosenone: An Access to Enantiopure (S)-Dairy Lactone

Molecules, 2016
Chiral epoxides—such as ethyl and methyl (S)-3-(oxiran-2-yl)propanoates ((S)-1a/1b)—are valuable precursors in many chemical syntheses. Until recently, these compounds were synthesized from glutamic acid in four steps (deamination, reduction, tosylation ...
Aurélien A. M. Peru, Amandine L. Flourat, Christian Gunawan, Warwick Raverty, Martyn Jevric, Ben W. Greatrex, Florent Allais   +6 more
doaj   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Mild Generation of Highly Nucleophilic N‐Heterocyclic Carbene Boryl Anion From Neutral sp2–sp3 Diboron Reagents and Its Applications in Nucleophilic Borylation

Angewandte Chemie, EarlyView.
A less hindered and highly nucleophilic N‐heterocyclic carbene (NHC) boryl anion is generated at room temperature by reacting sp2–sp3 diboron reagent (NHC)BH2Bpin with KOtBu. This highly reactive anion demonstrates broad reactivity with various electrophiles, including those traditionally considered inert, enabling their efficient borylation.
Weixuan Sun, Peiqi Zhang, Hairong Lyu
wiley   +2 more sources

Unexpected Formation of Oxetanes during the Synthesis of Dodeco-6,7-diuloses

Molbank, 2020
During the synthesis of symmetrical dodeco-6,7-diuloses that are potential candidates for inhibition of glycosidases, an unanticipated epoxide-oxetane rearrangement was observed.
Marius Bayer, Cäcilia Maichle-Mössmer, Thomas Ziegler   +2 more
doaj   +1 more source

Functional Polyester Synthesis from CO2, Butadiene and Epoxides [PDF]

, 2023
Yajun Zhao, Xiaohui Zhang, Zhuang Li, Shan Tang   +3 more
openalex   +1 more source

Ammonia Gas Sensor Fabricated by Multifunctional ZnO/GO Nanocomposites for Long‐Term, Self‐Powered Monitoring

Advanced Science, EarlyView.
Zinc oxide/graphene oxide (ZnO/GO) nanocomposites serve as a gas‐sensitive film for ammonia sensing and as high‐performance electrode materials in supercapacitors, simultaneously. A wearable contact‐separated triboelectric nanogenerator is designed to directly drive the ZnO/GO nanocomposites‐based ammonia sensor.
Xingwei Wang, Likun Gong, Xiaohong Zhou
wiley   +1 more source