Results 121 to 130 of about 101,558 (168)

Protein Engineering of Epoxide Hydrolase from Agrobacterium radiobacter AD1 for Enhanced Activity and Enantioselective Production of ( R )-1-Phenylethane-1,2-Diol

, 2005
Lingyun Rui, Cao Li, Wilfred Chen, Kenneth F. Reardon, Thomas K. Wood   +4 more
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Development of Recombinant Escherichia coli Expressing Rhodotorula glutinis Epoxide Hydrolase

, 2006
Soojung Lee, Hee‐Sook Kim
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Faculty Opinions recommendation of Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors.

, 2006
Deanna L. Kroetz
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Soluble Epoxide Hydrolase

Encyclopedia of Molecular Pharmacology, 2020
Nalin Singh, Bruce D. Hammock
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Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade

Expert Opinion on Therapeutic Patents, 2022
Introduction Biological effects mediated by the CYP450 arm of arachidonate cascade implicate the enzyme-soluble epoxide hydrolase (sEH) in hydrolyzing anti-inflammatory epoxy fatty acids to pro-inflammatory diols.
M. R. Iyer, Biswajit Kundu, Casey M Wood
semanticscholar   +1 more source

Cytosolic epoxide hydrolase

Chemico-Biological Interactions, 1988
Epoxide hydrolase activity is recovered in the high-speed supernatant fraction from the liver of all mammals so far examined, including man. For some as yet unexplained reason, the rat has a very low level of this activity, so that cytosolic epoxide hydrolase is generally studied in mice.
Joseph W. DePierre, Johan Meijer
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Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides.

Chemical Communications, 2020
Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design.
D. Hu, Xuncheng Zong, F. Xue, Chuang Li, Bochun Hu, Minchen Wu   +5 more
semanticscholar   +1 more source

The Telltale Structures of Epoxide Hydrolases

Drug Metabolism Reviews, 2003
Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds. They are known to play a key role in the control of potentially genotoxic epoxides that arise during metabolism of many lipophilic compounds.
Arand, Michael, Cronin, Annette, Oesch, Franz, Mowbray, Sherry L, Jones, T Alwyn   +4 more
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The interaction of cytosolic epoxide hydrolase with chiral epoxides

International Journal of Biochemistry, 1993
1. The kinetic parameters of the cytosolic epoxide hydrolase were examined with two sets of spectrophotometric substrates. The (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-phenylpropyl carbonate had a KM of 33 and 68 microns and a Vmax of 16 and 27 mumol/min/mg, respectively.
Bruce D. Hammock, Eric C. Dietze, Eiichi Kuwano   +2 more
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Stereoselectivities of microbial epoxide hydrolases

Current Opinion in Chemical Biology, 1999
Epoxide hydrolases from bacterial and fungal sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which yields the corresponding enantiomerically enriched vicinal diol and the remaining nonconverted epoxide, enantioconvergent processes are also possible, which lead to ...
Romano V. A. Orru, Kurt Faber
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