Results 131 to 140 of about 101,558 (168)
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Converting an Esterase into an Epoxide Hydrolase
Angewandte Chemie International Edition, 2009AbstractEntering the fold: A common structural motif in hydrolytic enzymes is the α,β‐hydrolase fold. The interconversion of one enzyme into another by introduction of mechanistically important residues is not enough; only substitution of a loop allows epoxide hydrolase activity in the esterase scaffold to be formed (see picture; structure comparison ...
Konstanze Stiba +7 more
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Membrane topology of epoxide hydrolase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990The amino acid sequences of epoxide hydrolase from rat, rabbit and human have been subjected to hydropathy analysis and a novel model for the membrane topology of this enzyme is presented. The enzyme would appear to be retained in microsomal membranes by a single transmembrane segment located at the N-terminus and the majority (96%) of the protein is ...
Michelle Lament +3 more
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Synthetic applications of epoxide hydrolases
Current Opinion in Chemical Biology, 2001There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using 'newly discovered' enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation ...
Roland Furstoss, Alain Archelas
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Enantioselectivities of yeast epoxide hydrolases for 1,2-epoxides
Tetrahedron: Asymmetry, 1999Abstract Kinetic resolution of homologous series of unbranched 1,2-epoxyalkanes (C-4 to C-12), 1,2-epoxyalkenes (C-4, C-6 and C-8), a 2,2-dialkylsubstituted epoxide (2-methyl-1,2-epoxyheptane) and a benzyloxy-substituted epoxide (benzyl glycidyl ether) was investigated using resting cells of 10 different yeast strains.
Botes, A.L. +3 more
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Polymorphisms in Human Soluble Epoxide Hydrolase [PDF]
Molecular Pharmacology, 2003 Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous substrates for hsEH. Enzyme activity in humans shows high interindividual variation (e.g., 500-fold in liver) suggesting the existence of regulatory and/or structural gene ...
Joseph E. Maxwell +9 more
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ChemInform Abstract: Epoxide Hydrolases and Their Synthetic Applications
ChemInform, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Romano V. A. Orru +3 more
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Rat Cytosolic Epoxide Hydrolase
1986Rat liver microsomal and cytosolic epoxide hydrolase may be distinguished through differences in substrate specificity: styrene 7,8-oxide is preferentially hydrolyzed by the microsomal form, while trans-stilbene oxide is the preferred substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of Sprague-Dawley
Ludwig Schladt +4 more
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Journal of the American Chemical Society, 2018
Directed evolution of limonene epoxide hydrolase (LEH), which catalyzes the hydrolytic desymmetrization reactions of cyclopentene oxide and cyclohexene oxide, results in (R,R)- and (S,S)-selective mutants. Their crystal structures combined with extensive
Zhoutong Sun +9 more
semanticscholar +1 more source
Directed evolution of limonene epoxide hydrolase (LEH), which catalyzes the hydrolytic desymmetrization reactions of cyclopentene oxide and cyclohexene oxide, results in (R,R)- and (S,S)-selective mutants. Their crystal structures combined with extensive
Zhoutong Sun +9 more
semanticscholar +1 more source
Biochemical and Biophysical Research Communications, 1996
We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in
Glenn D. Prestwich, Hubert Wojtasek
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We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in
Glenn D. Prestwich, Hubert Wojtasek
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ACS Catalysis, 2018
An epoxide hydrolase from Vigna radiata (VrEH2) affords partial enantioconvergence (84% ee) in the enzymatic hydrolysis of racemic p-nitrostyrene oxide (pNSO), mainly due to insufficient regioselectivity for the (S)-enantiomer (rS = αS/βS = 7.3).
Fu-Long Li +10 more
semanticscholar +1 more source
An epoxide hydrolase from Vigna radiata (VrEH2) affords partial enantioconvergence (84% ee) in the enzymatic hydrolysis of racemic p-nitrostyrene oxide (pNSO), mainly due to insufficient regioselectivity for the (S)-enantiomer (rS = αS/βS = 7.3).
Fu-Long Li +10 more
semanticscholar +1 more source