Results 171 to 180 of about 14,919 (226)

Overexpression of soluble epoxide hydrolase reduces post-ischemic recovery of cardiac contractile function. [PDF]

Biochem Pharmacol
Edin ML, Gruzdev A, Bradbury JA, Graves JP, Muse GW, Goulding DR, Lih FB, DeGraff LM, Zeldin DC.   +8 more
europepmc   +1 more source

Inhibitory Activity of Glycosides from <i>Elsholtzia ciliata</i> against Soluble Epoxide Hydrolase and Cytokines in RAW264.7 Cells. [PDF]

J Microbiol Biotechnol
Kim JH, Park JH, Han KS, Lee ES, Kim YG, Kim YI, Koo SC, Cho BO.   +7 more
europepmc   +1 more source

Effects of 17,18-Epoxyeicosatetraenoic Acid and 19,20-Epoxydocosapentaenoic Acid Combined with Soluble Epoxide Hydrolase Inhibitor <i>t</i>-TUCB on Brown Adipogenesis and Mitochondrial Respiration. [PDF]

Nutrients
Yang Y, Wu H, Xu X, Morisseau C, Lee KSS, Hammock BD, Chen J, Zhao L.   +7 more
europepmc   +1 more source

A Soluble Epoxide Hydrolase Inhibitor Improves Cerebrovascular Dysfunction, Neuroinflammation, Amyloid Burden, and Cognitive Impairments in the hAPP/PS1 TgF344-AD Rat Model of Alzheimer's Disease. [PDF]

Int J Mol Sci
Fang X, Border JJ, Zhang H, Challagundla L, Kaur J, Hwang SH, Hammock BD, Fan F, Roman RJ.   +8 more
europepmc   +1 more source

A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling. [PDF]

iScience
Li X, Kempf S, Delgado Lagos F, Ukan Ü, Popp R, Hu J, Frömel T, Günther S, Weigert A, Fleming I.   +9 more
europepmc   +1 more source

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Cytosolic epoxide hydrolase

Chemico-Biological Interactions, 1988
Epoxide hydrolase activity is recovered in the high-speed supernatant fraction from the liver of all mammals so far examined, including man. For some as yet unexplained reason, the rat has a very low level of this activity, so that cytosolic epoxide hydrolase is generally studied in mice.
J, Meijer, J W, DePierre
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Rat Cytosolic Epoxide Hydrolase

1986
Rat liver microsomal and cytosolic epoxide hydrolase may be distinguished through differences in substrate specificity: styrene 7,8-oxide is preferentially hydrolyzed by the microsomal form, while trans-stilbene oxide is the preferred substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of Sprague-Dawley
F, Oesch, L, Schladt, R, Hartmann, C, Timms, W, Wörner   +4 more
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Stereoselectivities of microbial epoxide hydrolases

Current Opinion in Chemical Biology, 1999
Epoxide hydrolases from bacterial and fungal sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which yields the corresponding enantiomerically enriched vicinal diol and the remaining nonconverted epoxide, enantioconvergent processes are also possible, which lead to ...
R V, Orru, K, Faber
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Membrane topology of epoxide hydrolase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
The amino acid sequences of epoxide hydrolase from rat, rabbit and human have been subjected to hydropathy analysis and a novel model for the membrane topology of this enzyme is presented. The enzyme would appear to be retained in microsomal membranes by a single transmembrane segment located at the N-terminus and the majority (96%) of the protein is ...
J A, Craft, S, Baird, M, Lamont, B, Burchell   +3 more
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Synthetic applications of epoxide hydrolases

Current Opinion in Chemical Biology, 2001
There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using 'newly discovered' enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation ...
A, Archelas, R, Furstoss
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