Results 181 to 190 of about 14,919 (226)

The Telltale Structures of Epoxide Hydrolases

Drug Metabolism Reviews, 2003
Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds. They are known to play a key role in the control of potentially genotoxic epoxides that arise during metabolism of many lipophilic compounds.
Arand, Michael, Cronin, Annette, Oesch, Franz, Mowbray, Sherry L, Jones, T Alwyn   +4 more
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The interaction of cytosolic epoxide hydrolase with chiral epoxides

International Journal of Biochemistry, 1993
1. The kinetic parameters of the cytosolic epoxide hydrolase were examined with two sets of spectrophotometric substrates. The (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-phenylpropyl carbonate had a KM of 33 and 68 microns and a Vmax of 16 and 27 mumol/min/mg, respectively.
E C, Dietze, E, Kuwano, B D, Hammock
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An Insect Juvenile Hormone-Specific Epoxide Hydrolase Is Related to Vertebrate Microsomal Epoxide Hydrolases

Biochemical and Biophysical Research Communications, 1996
We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in
H, Wojtasek, G D, Prestwich
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Epoxide hydrolase activity of Streptomyces strains

Journal of Biotechnology, 2000
The discovery of epoxide hydrolases within a Streptomyces sp. strain collection is described. Screening was performed in 96 well microtiter plates using a modified 4-(p-nitrobenzyl)pyridine assay with styrene oxide, 1,2-epoxy-hexane or 3-phenyl ethylglycidate (3-PEG) as substrates. Out of 120 strains investigated, S. antibioticus Tü4, S.
F, Zocher, M M, Enzelberger, U T, Bornscheuer, B, Hauer, W, Wohlleben, R D, Schmid   +5 more
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Soluble epoxide hydrolase and ischemic cardiomyopathy

International Journal of Cardiology, 2012
The development of cardiovascular disease has been linked to lowered levels of epoxyeicosatrienoic acids (EETs) in the cardiovascular system. Ischemic cardiomyopathy is caused by atherosclerotic lesions in multi-coronary arteries especially diffusive lesions, which can lead to severe myocardial dysfunction, heart enlargement, heart failure, or ...
Ting-Ting, Zhao, Binaya, Wasti, Dan-Yan, Xu, Li, Shen, Jian-Qing, Du, Shui-Ping, Zhao   +5 more
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Spectrophotometric Substrates for Cytosolic Epoxide Hydrolase

Analytical Biochemistry, 1994
In this study, we demonstrate the utility of a broad class of spectrophotometric substrates for the assay of cytosolic epoxide hydrolase purified from murine liver. These substrates, epoxy esters or carbonates, cyclize spontaneously upon or during hydrolysis of the epoxide functionality.
E C, Dietze, E, Kuwano, B D, Hammock
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Polymorphisms in Human Soluble Epoxide Hydrolase

Molecular Pharmacology, 2003
Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous substrates for hsEH. Enzyme activity in humans shows high interindividual variation (e.g., 500-fold in liver) suggesting the existence of regulatory and/or structural gene ...
Beata D, Przybyla-Zawislak, Punit K, Srivastava, Johana, Vazquez-Matias, Harvey W, Mohrenweiser, Joseph E, Maxwell, Bruce D, Hammock, J Alyce, Bradbury, Ahmed E, Enayetallah, Darryl C, Zeldin, David F, Grant   +9 more
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Epoxide Hydrolase in Human Fetal Liver

Pharmacology, 1983
Epoxide hydrolase activity towards styrene oxide was measured in the microsomal fraction of 20 human fetal livers. The enzymatic activity was 5.60 +/- 0.52 nmol/min/mg (mean +/- SE) which is about 40% of the previously reported value in human adult liver microsomes. No relation between enzymatic activity and fetal age was observed.
G M, Pacifici, A, Rane
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Epoxide hydrolase and hepatocarcinogenesis

Trends in Pharmacological Sciences, 1981
is commonly understood as a nonsynergistic or non-potentiating combination, whereas 'overadditive' is taken as synergism, also expressed as potentiation. The dose-additive method·'·" Table a) by differentiation of additive from overadditive effects allows conclusions about the mechanism of action of A and B.
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[46] Microsomal epoxide hydrolase

1981
Publisher Summary Microsomal epoxide hydrolase catalyzes the conversionof epoxides to glycols. The microsomal enzyme should not be confused with another epoxide hydrolase activity, found primarily in the cytosolic fraction, which differs greatly from membrane-bound enzyme in substrate specificity and immunological properties.
Thomas M. Guenthner, Philip Bentley, Franz Oesch   +2 more
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