Results 21 to 30 of about 101,558 (168)
Soluble Epoxide Hydrolase and Diabetes Complications
International Journal of Molecular Sciences, 2022 Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke.
Natasha Z. Anita, Walter Swardfager
openaire +2 more sources
Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia
Journal of Biological Chemistry, 2018 Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs).
M. Edin +12 more
semanticscholar +1 more source
Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
ChemistryEurope, EarlyView.This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley +1 more source
Inhibition of Soluble Epoxide Hydrolase for Renal Health
Frontiers in Pharmacology, 2019 A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates.
Jun-Yan Liu
semanticscholar +1 more source
Engineering of the Thiamine Diphosphate‐Dependent JanthE for the Synthesis of Tertiary Alcohols
Chemistry – A European Journal, EarlyView.The synthesis of chiral tertiary alcohols is in high demand. Here we investigate in detail the aldehyde–ketone cross‐coupling reactions catalyzed by the promising thiamine diphosphate‐dependent lyase JanthE. Focusing on both reaction parameters and engineering, we rationally develop JanthE to improve its applicability and demonstrate its evolvability ...
Lucrezia Lanza +7 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann +6 more
wiley +1 more source
Improvement of the Epoxide Hydrolase Properties for the Enantioselective Hydrolysis of Epoxides
Current Organic Chemistry, 2013 Peer ...
Solares, L. F., Mateo González, César
openaire +3 more sources
ChemSusChem, Accepted Article.Hydroxylated derivatives of arachidonic acid play crucial roles in physiology and inflammation response, with distinct biological effects for (R)‐ and (S)‐enantiomers, highlighting their pharmaceutical relevance. Here, we harness recombinant unspecific peroxygenases (UPOs)—from the fungi Coprinopsis cinerea (rCciUPO) and Agrocybe aegerita (rAaeUPO ...
Alejandro González-Benjumea +7 more
wiley +1 more source
ChemSusChem, EarlyView.Molecular solar thermal systems urge for innovative building blocks to increase their present limits in storage density and light activation window. Here, a complete computational study of loading and unloading mechanisms for an experimentally inspired system based on the Paternò–Büchi reaction is presented.
Marta Delgado‐Gómez +5 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.Lsd18 is a flavin‐dependent monooxygenase from Streptomyces lasalocidi that performs two enantioselective epoxidations during lasalocid A biosynthesis. X‐ray crystal structures of Lsd18 bound to a substrate and product analogue illuminate how this enzyme performs multiple epoxidations on the same substrate molecule and how it controls stereoselectivity.
Qian Wang +12 more
wiley +2 more sources