Results 21 to 30 of about 14,919 (226)
Physiological Reports, 2021 Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation of inflammation, vascular tone, hemostasis, and thrombosis.
Rachel E. Walker +4 more
doaj +1 more source
The impact of the soluble epoxide hydrolase cascade on periodontal tissues
Frontiers in Dental Medicine, 2023 Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing ...
Henrique Ballassini Abdalla +2 more
doaj +1 more source
Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase
Journal of Lipid Research, 2011 Hepoxilins are lipid signaling molecules derived from arachidonic acid through the 12-lipoxygenase pathway. These trans-epoxy hydroxy eicosanoids play a role in a variety of physiological processes, including inflammation, neurotransmission, and ...
Annette Cronin +2 more
doaj +1 more source
Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome
Case Reports in Medicine, 2018 Lamotrigine (LTG) is currently indicated as adjunctive therapy for focal and generalized tonic-clonic seizures and for treatment of bipolar disorder and neuropathic pain.
Marta Vázquez +6 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1 ...
Linlei Zhang +10 more
doaj +1 more source
Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation
Frontiers in Pharmacology, 2021 The soluble epoxide hydrolase (sEH) enzyme is a major regulator of bioactive lipids. The enzyme is highly expressed in liver and kidney and modulates levels of endogenous epoxy-fatty acids, which have pleiotropic biological effects including limiting ...
Karen M. Wagner +3 more
doaj +1 more source
Microsomal epoxide hydrolase polymorphisms
Molecular Medicine Reports, 2010 Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change tyrosine residue 113 to histidine (Tyr113His) and histidine 139 to arginine (His139Arg), respectively.
Pinarbasi, Hatice +2 more
openaire +5 more sources
Molecules, 2020 Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA4H).
Suaad A. Audat +6 more
doaj +1 more source
Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease
Cells, 2022 Cell responses to changes in their redox state are significantly mediated by reversible oxido-reductive post-translational modifications of proteins, potentially altering their activities or interactions.
Rebecca Charles, Philip Eaton
doaj +1 more source
Soluble Epoxide Hydrolase in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2010 Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim +3 more
openaire +4 more sources