Results 11 to 20 of about 11,968 (183)
Metabolites, 2020 While a complex network of cellular and molecular events is known to be involved in the pathophysiological mechanism of chronic kidney disease (CKD), the divergence point between reversal and progression and the event that triggers CKD progression are ...
Kyoung Hee Han +6 more
doaj +1 more source
Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity
Data in Brief, 2016 The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira +5 more
doaj +1 more source
Natural Product Communications, 2016 SMTPs, a family of natural small molecules that effectively treat ischemic stroke, are subject to clinical development. SMTPs enhance plasminogen activation and inhibit soluble epoxide hydrolase (sEH), leading to promotion of endogenous thrombolysis and ...
Shinya Otake +4 more
doaj +1 more source
Nature Communications, 2022 Chiral heterocyclic compounds are privileged structures in medicinal chemistry. Here, the authors report an in silico strategy for the enzymatic synthesis of pharmaceutically significant chiral N- and O-heterocycles via Baldwin cyclization of hydroxy ...
Jun-Kuan Li +9 more
doaj +1 more source
The impact of the soluble epoxide hydrolase cascade on periodontal tissues
Frontiers in Dental Medicine, 2023 Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing ...
Henrique Ballassini Abdalla +2 more
doaj +1 more source
Epoxide Hydrolases: Multipotential Biocatalysts
International Journal of Molecular Sciences, 2023 Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building blocks for bioactive compounds and drugs. In this review article, we discuss the state of the art and development potential of epoxide hydrolases as biocatalysts based on ...
Marek Bučko +4 more
openaire +2 more sources
Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase
Journal of Lipid Research, 2012 Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
doaj +1 more source
Journal of Lipid Research, 2014 Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity.
Kasem Nithipatikom +4 more
doaj +1 more source
Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism
Frontiers in Molecular Neuroscience, 2020 The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N ...
Michelle Flores Domingues +7 more
doaj +1 more source
Physiological Reports, 2021 Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation of inflammation, vascular tone, hemostasis, and thrombosis.
Rachel E. Walker +4 more
doaj +1 more source