Results 21 to 30 of about 67,478 (222)

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease [PDF]

, 2010
Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective.
Geisslinger, Gerd, Gerd Geisslinger, Tsai, Cindy, Ralf P. Brandes, Brandes, Ralf, Schäfer, Liliana, Amann Kerstin, Liliana Schaefer, Kerstin Amann, Felix Jansen, Jung, Oliver, Ralf P Brandes, Mieth Anja, Hwang Sung H., Schaefer Liliana, Anja Mieth, Hwang, Sung H., Barbosa-Sicard Eduardo, Sung H. Hwang, Bruce D. Hammock, Hammock Bruce D., Christophe Morisseau, Cindy Tsai, Rainer U. Pliquett, Oliver Jung, Brandes Ralf P., Pliquett Rainer U., Mieth, Anja, Babelova, Andrea, Barbosa Sicard, Eduardo, Geisslinger Gerd, Jansen, Felix, Andrea Babelova, Sung H Hwang, Morisseau, Christophe, Pliquett, Rainer U., Eduardo Barbosa-Sicard, Jung Oliver, Rainer U Pliquett, Bruce D Hammock, Jansen Felix, Tsai Cindy, Morisseau Christophe, Amann, Kerstin, Hammock, Bruce D., Babelova Andrea   +45 more
core   +2 more sources

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Alzheimer’s disease, cardiovascular disease, and other cardiometabolic disorders may share inflammatory origins. Lipid mediators, including oxylipins, endocannabinoids, bile acids, and steroids, regulate inflammation, energy metabolism, and ...
Kamil Borkowski, Theresa L. Pedersen, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, John W. Newman, Alzheimer’s Disease Metabolomics Consortium   +11 more
doaj   +1 more source

Soluble Epoxide Hydrolase in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2010
Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim, Ulu, Arzu, Zhang, Le-Ning, Hammock, Bruce   +3 more
openaire   +4 more sources

Mechanism of Chronic Kidney Disease Progression and Novel Biomarkers: A Metabolomic Analysis of Experimental Glomerulonephritis

Metabolites, 2020
While a complex network of cellular and molecular events is known to be involved in the pathophysiological mechanism of chronic kidney disease (CKD), the divergence point between reversal and progression and the event that triggers CKD progression are ...
Kyoung Hee Han, Bora Kim, Sang Chun Ji, Hee Gyung Kang, Hae Il Cheong, Joo-Youn Cho, Il-Soo Ha   +6 more
doaj   +1 more source

Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity

Data in Brief, 2016
The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira, Patricia Pereira Adriani, Flavia Garcia Borges, Adriana Rios Lopes, Patricia T. Campana, Felipe S. Chambergo   +5 more
doaj   +1 more source

Isoprene Side-chain of SMTP is Essential for Soluble Epoxide Hydrolase Inhibition and Cellular Localization

Natural Product Communications, 2016
SMTPs, a family of natural small molecules that effectively treat ischemic stroke, are subject to clinical development. SMTPs enhance plasminogen activation and inhibit soluble epoxide hydrolase (sEH), leading to promotion of endogenous thrombolysis and ...
Shinya Otake, Norihiro Ogawa, Yoshikazu Kitano, Keiji Hasumi, Eriko Suzuki   +4 more
doaj   +1 more source

The impact of the soluble epoxide hydrolase cascade on periodontal tissues

Frontiers in Dental Medicine, 2023
Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing ...
Henrique Ballassini Abdalla, Thomas E. Van Dyke, Thomas E. Van Dyke   +2 more
doaj   +1 more source

Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles

Nature Communications, 2022
Chiral heterocyclic compounds are privileged structures in medicinal chemistry. Here, the authors report an in silico strategy for the enzymatic synthesis of pharmaceutically significant chiral N- and O-heterocycles via Baldwin cyclization of hydroxy ...
Jun-Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa-Guang Zhang, Wuyuan Zhang, Jun-An Ma, Manfred T. Reetz, Zhoutong Sun   +9 more
doaj   +1 more source

Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase

Journal of Lipid Research, 2012
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
doaj   +1 more source