Results 21 to 30 of about 11,968 (183)

Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase

Journal of Lipid Research, 2011
Hepoxilins are lipid signaling molecules derived from arachidonic acid through the 12-lipoxygenase pathway. These trans-epoxy hydroxy eicosanoids play a role in a variety of physiological processes, including inflammation, neurotransmission, and ...
Annette Cronin, Martina Decker, Michael Arand   +2 more
doaj   +1 more source

Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation

Frontiers in Pharmacology, 2021
The soluble epoxide hydrolase (sEH) enzyme is a major regulator of bioactive lipids. The enzyme is highly expressed in liver and kidney and modulates levels of endogenous epoxy-fatty acids, which have pleiotropic biological effects including limiting ...
Karen M. Wagner, Jun Yang, Christophe Morisseau, Bruce D. Hammock   +3 more
doaj   +1 more source

Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome

Case Reports in Medicine, 2018
Lamotrigine (LTG) is currently indicated as adjunctive therapy for focal and generalized tonic-clonic seizures and for treatment of bipolar disorder and neuropathic pain.
Marta Vázquez, Cecilia Maldonado, Natalia Guevara, Andrea Rey, Pietro Fagiolino, Antonella Carozzi, Carlos Azambuja   +6 more
doaj   +1 more source

Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease

Cells, 2022
Cell responses to changes in their redox state are significantly mediated by reversible oxido-reductive post-translational modifications of proteins, potentially altering their activities or interactions.
Rebecca Charles, Philip Eaton
doaj   +1 more source

Protective Effects of the Soluble Epoxide Hydrolase Inhibitor 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea in a Rat Model of Permanent Middle Cerebral Artery Occlusion

Frontiers in Pharmacology, 2020
Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1 ...
Linlei Zhang, Linlei Zhang, Shasha Xu, Xiaoxiao Wu, Farah Mohamed Muse, Jiaou Chen, Yungang Cao, Jueyue Yan, Zicheng Cheng, Xingyang Yi, Zhao Han   +10 more
doaj   +1 more source

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]

Physiological Reviews, 2012
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
openaire   +2 more sources

Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Molecules, 2020
Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA4H).
Suaad A. Audat, Nizar A. Al-Shar’i, Buthina A. Al-Oudat, Amanda Bryant-Friedrich, Mel F. Bedi, Aref L. Zayed, Qosay A. Al-Balas   +6 more
doaj   +1 more source

Evaluation and clinical implications of interactions between compound Danshen dropping pill and warfarin associated with the epoxide hydrolase gene

Frontiers in Pharmacology, 2023
Introduction: In clinical practice, warfarin is often combined with Compound Danshen dripping pill (CDDP) for the treatment of cardiovascular diseases.
Xixi Chen, Xixi Chen, Xurui Zuo, Yingqiang Zhao, Yuhong Huang, Chunxiao Lv   +5 more
doaj   +1 more source

Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death

Molecules
Nineteen potential mimics of 8,9-epoxyeicosatrienoic acid (8,9-EET), a natural bioactive oxylipin, were synthesized and evaluated for their ability to protect renal mesangial cells against sorafenib-induced cell death in a water-soluble tetrazolium (WST ...
Marcus de Bourg, Abhishek Mishra, Rawand S. Mohammad, Christophe Morisseau, Bruce D. Hammock, John D. Imig, Anders Vik   +6 more
doaj   +1 more source

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial ...
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Gavin Y. Oudit, John M. Seubert, John M. Seubert, John M. Seubert   +15 more
doaj   +1 more source