Results 61 to 70 of about 15,949 (256)

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Water‐Soluble POSS Promotes Concurrent Coalescence and Crosslinking for Multiscale‐Reinforced, Coalescent‐Free Waterborne Coatings

Advanced Science, EarlyView.
Water‐soluble amine‐functionalized polyhedral oligomeric silsesquioxane promotes concurrent latex coalescence and crosslinking, allowing epoxy‐functional particles to form continuous films without added volatile coalescing agents. The resulting multiscale‐reinforced waterborne coatings combine high strength, toughness, optical transparency, scratch ...
Chao Wang, Bin Wu, Lin Li, Yibo Ru, Xiaohe Zhang, Minlong Wang, Ruoyan Yang, Jie An   +7 more
wiley   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Bio-Inspired Metal-Free Catalysis: Natural Sugars Enable Efficient CO₂ Conversion into Cyclic Carbonates

Organics
The consistent increase in atmospheric CO2 concentration, mostly driven by the global combustion of fossil fuels, is considered one of the primary contributors to the increasing severity of environmental problems, like climate change and global warming ...
Oscar A. Douglas-Gallardo, Valentino Cárdenas-Toledo, Marta Navarro, Enrique Francés-Poveda, Jesús Naranjo, Genesys L. Mahecha, Felipe de la Cruz-Martínez, Francisca Werlinger, Agustín Lara-Sánchez, Javier Martínez   +9 more
doaj   +1 more source

4,4-Dimethyl-A-homoandrostane epoxides

, 1983
The configuration of the oxygen-containing substituent in the position 3 of some 4,4-dimethyl-A-homo-4a-androstene derivatives was determined and their epimeric 4a,5-epoxides were prepared.
Helena Velgová
core   +1 more source

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Enantioselective Syntheses of 2‑Azabicyclo[2.2.1]heptanes via Brønsted Acid Catalyzed Ring-Opening of meso-Epoxides

A chiral phosphoric acid-catalyzed ring-opening of meso-epoxides was developed. A range of 2-azabicyclo[2.2.1]­heptanes were obtained in high yields with excellent enantioselectivities.
Jiao Ma (1310886), Aijun Lin (1393531), Qimin Wu (1878631), Hequan Yao (1393537), Min Cai (388864)   +4 more
core   +1 more source

Ethanolysis of Steroidal Epoxides Catalysed by Tetracyanoethylene

, 2010
Ethanolysis of the epimeric androstane 4,5- and 5,6- epoxides catalysed by tetracyanoethylene is reported. In contrast to other reagents, these reactions involve the mild room temperature trans diaxial opening of the epoxides.
Cavit Uyanik, Olcay Koca, Koca, Olcay, Uyanik, CAVİT   +3 more
core   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Facile Conversion of Epoxides to 1,2-Diacetates with NaOAc•3H2O/Ac2O System [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2016
This study represents a highly efficient and regioselective ring-opening of epoxides with acetic anhydride in the presence of NaOAc·3H2O at solvent-free conditions.
Masumeh Gilanizadeh, Behzad Zeynizadeh
doaj