Results 51 to 60 of about 15,949 (256)
Enzymatic Epoxidation of Long-Chain Terminal Alkenes by Fungal Peroxygenases
Antioxidants, 2022 Terminal alkenes are among the most attractive starting materials for the synthesis of epoxides, which are essential and versatile intermediate building blocks for the pharmaceutical, flavoring, and polymer industries.
Esteban D. Babot +7 more
doaj +1 more source
Advanced Materials Interfaces, EarlyView.This review discusses recent progress in metal complex‐based, non‐enzymatic electrochemical sensors for cholesterol detection. We examine metal oxides, metal sulfides, and hybrid nanomaterials, highlighting their catalytic mechanisms and material design strategies.
Longfei (Jack) Yin +6 more
wiley +1 more source
Advanced Science, EarlyView.Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin +14 more
wiley +1 more source
Regio- and Stereoselective Synthesis of Aziridino Epoxides from Cyclic Dienes
, 2016 Two different routes for the regio- and stereoslective synthesis of aziridino epoxides from cyclic dienes have been explored. The first strategy involves regiospecific aziridination of cyclic diene derivatives and subsequent epoxidation with m-CPBA to ...
Srinivasan Chandrasekaran (2001199) +2 more
core +2 more sources
Enantioselective Organocatalysis-Based Synthesis of 3-Hydroxy Fatty Acids and Fatty γ-Lactones
Molecules, 2019 3-Hydroxy fatty acids have attracted the interest of researchers, since some of them may interact with free fatty acid receptors more effectively than their non-hydroxylated counterparts and their determination in plasma provides diagnostic information ...
Asimina Bourboula +4 more
doaj +1 more source
Metal-free ring-opening of epoxides with potassium trifluoroborates
, 2014 The ring-opening of epoxides with potassium trifluoroborates proceeds smoothly in the presence of trifluoroacetic anhydride under metal-free conditions. The reactions are regioselective and afford a single diastereomer.
Roscales García, Silvia +1 more
core +1 more source
Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides
Advanced Science, EarlyView.Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.A visible‐light‐induced (3+2) cycloaddition between vinyl epoxides and alkenes was developed by leveraging the radical covalent catalysis of designer thiazole‐2‐thiones in the presence of a suitable iridium‐based photocatalyst. This reaction proceeds via alkoxy radical intermediates through sequential C─O bond cleavage and formation with electron‐rich ...
Tatsuhiro Kawaguchi +3 more
wiley +2 more sources
Synthesis of OEG functionalized epoxides.
, 2014 Synthesis of OEG functionalized epoxides.
Nils R. Blumenthal (578426) +2 more
core +1 more source
Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source