Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion
Chemistry – A European Journal, EarlyView.An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang +10 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
RhodaMal Dyes: Novel Red Emissive Fluorophores as Probes for High Contrast Live‐Cell Imaging
Chemistry – A European Journal, EarlyView.Incorporation of malononitrile into the traditional rhodol framework furnishes RhodaMal (Rhoda = Rhodamine, Mal = Malononitrile;) dyes, a new class of red emissive push–pull chromophores. Conjugating them to triphenylphosphonium cation enables live cell super‐resolution STED microscopy with a 775 nm depletion laser.
A. Mavroskoufis +8 more
wiley +1 more source
The Cytotoxicity of Epsilon Toxin from Clostridium perfringens on Lymphocytes Is Mediated by MAL Protein Expression. [PDF]
Mol Cell Biol, 2018 Blanch M +8 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup +5 more
wiley +1 more source
Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]
PLoS Pathog, 2019 Linden JR +7 more
europepmc +1 more source
Carba‐closo‐dodecaborates as Superchaotropic Anions
Chemistry – A European Journal, EarlyView.The singly charged boron cluster anion CB11H12– forms strong inclusion complexes with cyclodextrins, interacts strongly with nonionic polymers, and serves as an effective transmembrane carrier, positioning itself as the smallest superchaotropic anion known to date. .
Andrea Barba‐Bon +8 more
wiley +1 more source
Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors. [PDF]
Virulence, 2018 Gao J +10 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.We report a cellular membrane‐targeted europium(III) probe, Eu.Chol, that enables selective, time‐resolved detection of peroxynitrite (ONOO−) at the cell membrane interface. Eu.Chol demonstrates efficient incorporation into liposomes and Jurkat cells, with minimal response to H2O2, establishing a modular platform for subcellular ONOO− sensing ...
Jamie Webb +6 more
wiley +1 more source
A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization. [PDF]
Antibodies (Basel), 2018 Linden JR +10 more
europepmc +1 more source