Results 141 to 150 of about 1,328,799 (258)

Randomized Phase II Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: KCSG HN19‐09, CONPELAN Study

open access: yesHead &Neck, Volume 48, Issue 11, Page 3103-3112, November 2026.
ABSTRACT Background The benefit of consolidation programmed cell death protein 1 (PD‐1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II–IVB NPC were randomized (2:1) to pembrolizumab 200 mg or placebo every 3 weeks for up to 17 cycles after chemoradiotherapy ...
Sang Hoon Chun   +11 more
wiley   +1 more source

Challenges and Opportunities of Human Immunodeficiency Virus, Hepatitis B Virus and Hepatitis C Virus Control and Elimination Policies, Regulations, and Strategies in Ethiopia

open access: yesHealth Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) remain major public health challenges globally and in Ethiopia. Although policies, regulations, and strategies have been developed to support their control and elimination, translating these policy commitments into effective implementation ...
Mequanente Dagnaw   +2 more
wiley   +1 more source

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song   +9 more
wiley   +1 more source

Liquid Biopsy: Past, Present, and Future

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu   +8 more
wiley   +1 more source

Epstein-Barr virus (EBV) infection causes human germinal center B cell-derived lymphomas in the absence of EBNA2 expression. [PDF]

open access: yesProc Natl Acad Sci U S A
Wang C   +11 more
europepmc   +1 more source

Estimating Individualized Survival Benefit of Consolidative Metastasis‐Directed Radiotherapy Following Chemoimmunotherapy in Nasopharyngeal Carcinoma With Exclusive Distant Metastasis

open access: yesMedComm, Volume 7, Issue 11, November 2026.
This study integrates target trial emulation and causal machine learning to individualize consolidative metastasis‐directed radiotherapy (MDRT) for exclusively distant metastatic nasopharyngeal carcinoma. Using a multicenter cohort of 1083 patients, we confirmed overall MDRT efficacy via a cloning–censoring–weighting approach.
Xuguang Wang   +13 more
wiley   +1 more source

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