Results 41 to 50 of about 6,731 (217)

Cryo-EM structures of full-length integrin αIIbβ3 in native lipids

Nature Communications, 2023
Platelet integrin αIIbβ3 is maintained in a bent inactive state (low affinity to physiologic ligand), but can rapidly switch to a ligand-competent (high-affinity) state in response to intracellular signals (“inside-out” activation).
Brian D. Adair, Jian-Ping Xiong, Mark Yeager, M. Amin Arnaout   +3 more
doaj   +1 more source

P2Y12 Receptor Blockade Augments Glycoprotein IIb‐IIIa Antagonist Inhibition of Platelet Activation, Aggregation, and Procoagulant Activity [PDF]

, 2014
Background: New antiplatelet agents that provide greater, more consistent inhibition of the platelet ADP receptor P2Y12 may be used in combination with glycoprotein (GP) IIb‐IIIa antagonists, but their combined effect on platelet function and ...
Barnard, Marc R., Berny‐Lang, Michelle A., Frelinger, Andrew L., Jakubowski, Joseph A., Michelson, Alan D., Sugidachi, Atsuhiro   +5 more
core   +1 more source

Design of termo-sensitive molecularly imprinted polymers(MIP) and in vitro evaluation of controlled release of Eptifibatide drug [PDF]

شیمی کاربردی روز
In this research, a nano polymer was fabricated via the molecular imprinted polymer (MINP) method to transport and control the release of the drug eptifibatide.
Sharif Kaamyabi, Negar Karimi Hajishoreh, Abolfazl Akbarzadeh   +2 more
doaj   +1 more source

Standardizing the Clinical Approach to Cancer Therapy‐Related Cardiac Dysfunction: Applying Cardio‐Oncology Guidelines as a Practical Tool for Hematology and Oncology Providers

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Introduction and Methods Cancer therapy–related cardiac dysfunction (CTRCD) is a well established and potentially life‐threatening complication of contemporary oncologic treatment. Although comprehensive cardio‐oncology guidelines have been developed, their integration into routine hematology and oncology practice remains inconsistent.
Abdelrahman Ali, Suparna C. Clasen, Anne Blaes, Stephen Casselli, Anita Deswal, Susan Halli Demeter, Gregory Durm, Anecita Fadol, Alessandra Ferrajoli, Michael G. Fradley, Joerg Herrmann, Borja Ibanez, Sue Koob, Bogda Koczwara, Kasey J. Leger, Jennifer E. Liu, Teresa López‐Fernández, Alexander R. Lyon, N. G. Choon Ta, John Teerlink, Eric H. Yang, Susan Dent, Daniel Lenihan   +22 more
wiley   +1 more source

CAN3: BASELINE COST OF ILLNESS OF PARKINSON'S DISEASE IN A LARGE HEALTHCARE PLAN [PDF]

, 2000
We present a mixed finite element formulation for the spatial discretization in dynamic analysis of non-isothermal variably saturated porous media using different order of approximating functions for solid displacements and fluid pressures/temperature ...
Cao, Toan Duc, Sanavia, Lorenzo, Schrefler, B. A., Wang, Yongqi   +3 more
core   +1 more source

Distinct Thromboxane A₂–Dependent Pathways Regulate Arachidonic Acid–Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real‐Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition

Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.
ABSTRACT Platelets, as anucleate blood cells, play a pivotal role in the pathogenesis of cardiovascular diseases (CVDs), making antiplatelet therapy essential for preventing thrombotic events such as myocardial infarction. Thromboxane A₂ (TXA₂) is a key pro‐aggregatory mediator that drives platelet activation.
Joen‐Rong Sheu, Wei‐Chieh Huang, Chao‐Chien Chang, Chih‐Wei Hsia, Chih‐Hsuan Hsia, Thanasekaran Jayakumar, Shaw‐Min Hou   +6 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Inhibition of platelet adhesion, thrombus formation, and fibrin formation by a potent αIIbβ3 integrin inhibitor from ticks

Research and Practice in Thrombosis and Haemostasis, 2021
Background Ticks puncture the skin of their hosts and secrete saliva, containing antiplatelet proteins, into the blood. Here, we studied disagregin, a potent platelet‐inhibiting protein derived from the salivary glands of Ornithodoros moubata, an African
Danique L. van denKerkhof, Magdolna Nagy, Kanin Wichapong, Sanne L.N. Brouns, Johan W. M. Heemskerk, Tilman M. Hackeng, Ingrid Dijkgraaf   +6 more
doaj   +1 more source

Repeated Intravenous Thrombolysis in Patients with Recurrent Ischemic Stroke in the Vertebrobasilar Territory

Case Reports in Neurology, 2021
Acute ischemic vertebrobasilar stroke (AIVBS) is usually associated with poor outcome and prognosis and in case of basilar artery occlusion (BAO) with high mortality.
David Černík, Dušan Ospalík, Daniel Šaňák, Filip Cihlář   +3 more
doaj   +1 more source

Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction [PDF]

, 2015
British Heart Foundation (PG/12/68/29779 and PG/14/48/30916) and the Wellcome Trust (101604/Z/13/Z to SN and TW, and 098291/Z/12/Z to S.N)
Abbott, Altieri, Alugupalli, Armstrong, Armstrong, Armstrong, Armstrong, Cattaneo, Cattaneo, Chan, Chan, Clark, di Minno, D’Souza, Fox, Freyer, Harrison, Hirsh, Huo, Iyú, Kevil, Kirkby, Konstantopoulos, Languino, Languino, Ley, Lordkipanidzé, McCaffery, Melissa V. Chan, Michaela Finsterbusch, Michelson, Nakamura, Nancy Hogg, Nicholas S. Kirkby, Patrono, Paul, Paul C. J Armstrong, Projahn, Rand, Shankar, Sussan Nourshargh, Threadgill, Timothy D. Warner, Turner, von Brühl, Warner, Woulfe, Xu   +47 more
core   +1 more source