Results 131 to 140 of about 39,716 (256)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Five-year follow-up results of the PROFHER trial comparing operative and non-operative treatment of adults with a displaced fracture of the proximal humerus [PDF]

, 2017
AIMS: The PROximal Fracture of the Humerus Evaluation by Randomisation (PROFHER) randomised clinical trial compared the operative and non-operative treatment of adults with a displaced fracture of the proximal humerus involving the surgical neck. The aim
Billingham LJ, Chen Z, Corbacho B, Dawson J, Dawson J, Handoll H, Handoll H, Handoll HH, Hodgson SA, Neer CS II, Peters SA, Rangan A   +11 more
core   +3 more sources

Quality of life in community-dwelling Dutch elderly measured by EQ-5D-3L [PDF]

Health and Quality of Life Outcomes, 2017
We aimed to evaluate health status and associated factors in community-dwelling elderly in the Netherlands.Participants from a placebo-controlled double-blind randomized controlled trial conducted in the Netherlands were invited at the time of enrolment to participate in this study. Data were collected on comorbidities, socio-demographic background and
Mangen, Marie-Josée J, Bolkenbaas, Marieke, Huijts, Susanne M, van Werkhoven, Cornelis H, Bonten, Marc J M, de Wit, G Ardine   +5 more
openaire   +3 more sources

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

EQ-5D-5L versus 3L: the impact on cost-effectiveness [PDF]

, 2017
Objectives To model the relationship between EQ-5D-3L and EQ-5D-5L and examine how differences impact on cost-effectiveness in case studies. Methods We used two datasets that included both EQ-5D-3L and EQ-5D-3L from the same respondents.
Barton, G., Gomes, M., Grimm, S., Hernandez Alava, M., Irvine, L., Meads, D., O'Dwyer, J., Pudney, S., Sadique, Z., Wailoo, A.J.   +9 more
core  

Mapping Functions in Health-Related Quality of Life: Mapping From Two Cancer-Specific Health-Related Quality-of-Life Instruments to EQ-5D-3L. [PDF]

, 2015
BACKGROUND: Clinical trials in cancer frequently include cancer-specific measures of health but not preference-based measures such as the EQ-5D that are suitable for economic evaluation.
Brazier, JE, Longworth, L, Mukuria, C, Rowen, D, Young, TA   +4 more
core   +2 more sources

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source

Spironolactone for People Age 70 Years and Older With Osteoarthritic Knee Pain:A Proof‐of‐Concept Trial [PDF]

, 2016
Objective: To determine whether spironolactone could benefit older people with osteoarthritis (OA), based on a previous study showing that spironolactone improved quality of life. Methods: This parallel-group, randomized, placebo-controlled, double-blind
Argo, Ishbel, Cvoro, Vera, Donnan, Peter T., Littleford, Roberta, McMurdo, Marion E. T., Rauchhaus, Petra, Struthers, Allan D., Sumukadas, Deepa, Waldie, Helen, Witham, Miles D.   +9 more
core   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source