Results 141 to 150 of about 134,162 (275)

Mapping Sri Lankan EQ-5D-3L to EQ-5D-5L value sets

, 2017
Objectives: Quality-adjusted life-years are the common outcome measure in contemporary economic evaluations in health care. Due to the limitations of the sensitivity of the EQ-5D-3L in specific disease conditions, the EuroQoL group has developed a new
Scuffham, Paul, Kularatna, Sanjeewa, Byrnes, J, Paul A. Scuffham, Kularatna, S, Scuffham, PA, Byrnes, Josh, Scuffham, Paul A., Sanjeewa Kularatna, Chen, Gang, Josh Byrnes, Gang Chen, Byrnes, Joshua, Chen, G   +13 more
core   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Durable Fuel Cell Cathode Enabled by Pt Embedded Nanoscale Carbon Network via a Scalable Process

Carbon Energy, EarlyView.
Platinum nanoparticles embedded nanoscale carbon network (Pt‐e‐Cn) are developed via a scalable flame spray pyrolysis process. Proton exchange membrane fuel cells (PEMFC) employing mesoporous Pt‐e‐Cn cathode electrocatalysts exhibit exceptional durability without compromising performance.
Suriya Venkatesan, Jens Mitzel, Tobias Morawietz, Emmanuelle Boehm‐Courjault, Deven P. Estes, Laure Guétaz, Indro Biswas, Jan Van Herle, Karsten Wegner, Pawel Gazdzicki, Kaspar Andreas Friedrich   +10 more
wiley   +1 more source

Comparison of EQ-5D-5L health state utilities using four country-specific tariffs on a breast cancer patient sample in mainland China

, 2017
Liu Liu,1,2 Shunping Li,1,2 Min Wang,3 Gang Chen4 1School of Health Care Management, Shandong University, Jinan, China; 2Key Laboratory of Health Economics and Policy Research, NHFPC (Shandong University), Jinan, China; 3Qingdao Municipal Hospital ...
Wang M, Liu L, Chen G, Li SP
core  

Modular One‐Pot Access to π‐Expanded Tetrakis(Phenothiazinyl)‐Silanes With Broadly Tunable Redox and Emission Properties

Chemistry – A European Journal, EarlyView.
A library of 21 tetrakis(phenothiazinyl)‐substituted silanes with broadly variable substituent decoration, which are fully reversible multistage redox systems with intense tunable emission from deep blue to yellow–green (441–533 nm), was rapidly synthesized by bromine–lithium exchange/borylation–Suzuki coupling of tetrakis(4‐bromophenyl)silane or by ...
Thomas P. M. Merke, Lysander Presser, Leonard Karl, Christian Ganter, Thomas J. J. Müller   +4 more
wiley   +1 more source

A comparison of United States and United Kingdom EQ-5D health states valuations using a nonparametric Bayesian method [PDF]

Few studies have compared preference values of health states obtained in different countries. This paper applies a nonparametric model to estimate and compare EQ-5D health state valuation data obtained from two countries using Bayesian methods.
Kharroubi, SA, Brazier, JE, O'Hagan, A
core  

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

An Evaluation of Generic and Disease‐Specific Patient‐Reported Outcome Measures to Assess the Impact of Percentage of Scalp Hair Loss on Health‐Related Quality of Life in a European Population

JEADV Clinical Practice
Background Hair loss due to alopecia areata (AA) can negatively impact patients’ health‐related quality of life (HRQoL). Patient‐reported outcome measures (PROMs) like the EQ‐5D‐5L and the Alopecia Areata Patient Priority Outcomes (AAPPO) represent ...
K. A. Hanson, S. Marwaha, S. K. Kurosky, M. Harries, P. Anderson, J. Piercy, V. Basey, J. Austin, E. H. Law   +8 more
doaj   +1 more source

Additional file 2: of Head-to-head comparison between the EQ-5D-5L and the EQ-5D-3L in general population health surveys

, 2018
EQ-5D-5L comparison between 5th and 6th waves to assess effect of administering it after EQ-5D-3L.
MĂłnica Ávila (3585170), Carlos G. Forero (2793622), Juan CabasĂŠs (5639924), Ricard Tresserras (2064124), Antonia Medina-Bustos (5117330), Montse Ferrer (436419), Marc MartĂ­-Pastor (5639906), Luis Rajmil (5609885), Yolanda Pardo (3585161), Angels Pont (3585158), Gemma Vilagut (418578), Olatz Garin (178963), Oriol Garcia-Codina (5117333), Jordi Alonso (178939)   +13 more
core   +1 more source

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source