Results 121 to 130 of about 134,162 (275)

Mean (SD) of deviations from reference norms: EQ-5D-5L index and EQ-VAS.

, 2018
Mean (SD) of deviations from reference norms: EQ-5D-5L index and EQ-VAS.
Eric Van Ganse (5680409), Montse Ferrer (436419), Marc Martí-Pastor (5639900), Àngels Pont (5680406), Gimena Hernandez (5680400), Laurent Laforest (5680412), Marijn de Bruin (309168), Alexandra L. Dima (5680403), Olatz Garin (178963), Jordi Alonso (178939), Karina Mayoral (5680415)   +10 more
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Head-to-Head Comparison of EQ-5D-3L and EQ-5D-5L Health Values [PDF]

, 2018
The EQ-5D is a widely used preference-based instrument to measure health-related quality of life. Some methodological drawbacks of its three-level version (EQ-5D-3L) prompted development of a new format (EQ-5D-5L). There is no clear evidence that the new
Krabbe, Paul F M; id_orcid, Buskens, Erik; id_orcid, Krabbe, Paul F M, Paul F. M. Krabbe, Selivanova, Anna, Anna Selivanova, Buskens, Erik, Erik Buskens   +7 more
core   +2 more sources

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Regression models of EQ-5D-5L and EQ-VAS deviation from norms regarding gender.

, 2018
Regression models of EQ-5D-5L and EQ-VAS deviation from norms regarding gender.
Eric Van Ganse (5680409), Montse Ferrer (436419), Marc Martí-Pastor (5639900), Àngels Pont (5680406), Gimena Hernandez (5680400), Laurent Laforest (5680412), Marijn de Bruin (309168), Alexandra L. Dima (5680403), Olatz Garin (178963), Jordi Alonso (178939), Karina Mayoral (5680415)   +10 more
core   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Comparison of the EQ-5D-3L and EQ-5D-5L instruments in patients undergoing unicompartmental knee arthroplasty

Frontiers in Medicine
PurposeThe purpose of this investigation is to assess and contrast the effectiveness of the two EuroQol five dimensions questionnaire (EQ-5D) versions—EQ-5D-3L and EQ-5D-5L—in assessing one-year quality of life outcomes for patients with knee ...
Zhipeng Tai, Zhipeng Tai, Dongping Wan, Qiang Zan, Yuanchi Huang, Chao Xu   +5 more
doaj   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China

Health and Quality of Life Outcomes
Purpose Different health-related quality of life scales are suitable for various populations and scenarios; hence, the selection of measurement tools must be based on research objectives and focal points.
Gang Liang, Ai-Xue Zhang, Fang-Yu Li, Jian-Hua Liu, Ya-Jie Zheng, Yu Qin, Yue-Zu Li, Rong Ma, Chen-Wei Pan, Dan-Lin Li, Pei Wang   +10 more
doaj   +1 more source

The EQ-5D-5L valuation study for Trinidad and Tobago

Health and Quality of Life Outcomes
AbstractPurposeThe 2016 EQ-5D-3L value set for Trinidad and Tobago (T&T) allows for the calculation of EQ-5D-5L values via the crosswalk algorithm. The 2016 value set was based on methods predating the EQ-VT protocol, now considered the gold standard for developing EQ-5D value sets.
Henry Bailey, Marcel F. Jonker, Eleanor Pullenayegum, Fanni Rencz, Bram Roudijk   +4 more
openaire   +3 more sources