Results 101 to 110 of about 35,541 (284)

Patient preference as a predictor of outcomes in a pilot trial of person-centred counselling versus low-intensity cognitive behavioural therapy for persistent sub-threshold and mild depression [PDF]

, 2017
The aim of this analysis was to explore whether pre-treatment intervention preferences were related to outcomes for patients with persistent sub-threshold and mild depression who received one of two treatment types. Thirty-six patients took part in a two-
Cooper, Mick, Elliott, Robert, Freire, Elizabeth, Heard, Deborah, McConnachie, Alex, Messow, Claudia-Martina, Morrison, Jill, Williams, Christopher   +7 more
core   +2 more sources

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Evaluation of the EQ-5D-3L and 5L versions in low back pain patients

Health and Quality of Life Outcomes, 2021
Background The EuroQol EQ-5D is one of the most widely researched and applied patient-reported outcome measures worldwide. The original EQ-5D-3L and more recent EQ-5D-5L include three and five response categories respectively.
A. M. Garratt, H. Furunes, C. Hellum, T. Solberg, J. I. Brox, K. Storheim, L. G. Johnsen   +6 more
doaj   +1 more source

Response process validity of three patient reported outcome measures for people requiring kidney care:a think-aloud study using the EQ-5D-5L, ICECAP-A and ICECAP-O [PDF]

, 2020
OBJECTIVES: To determine the response process validity, feasibility of completion, acceptability and preferences for three patient-reported outcome measures that could be used in economic evaluation-the EQ-5D-5L, ICECAP-A and ICECAP-O-in people requiring
Caskey, Fergus J, Coast, Joanna, Mitchell, Paul M, Sanghera, Sabina, Scott, Jemima   +4 more
core   +3 more sources

An Experience-Based Value Set for the EQ-5D-5L in Germany [PDF]

Value in Health, 2017
Valuation of health states provides a summary measure useful to health care decision makers. Results may depend on whether the currently experienced health state or a hypothetical health state is being evaluated. This study derives a value set for the EuroQoL Five-Dimensional Five-Level Questionnaire (EQ-5D-5L) by focusing on the individual's current ...
Leidl, R., Reitmeir, P.
openaire   +3 more sources

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Population norms for the EQ-5D-3L and EQ-5D-5L in Romania

Health and Quality of Life Outcomes, 2023
Background The majority of patient reported outcome measures (PROMs) don’t have population norms in Romania. This is the case with the EQ-5D as well. Therefore, we aimed to estimate population norms for the Romanian versions of the EQ-5D-5L, EQ-5D-3L ...
Elena Olariu, Raluca Caplescu, Luke Vale, Ileana Gabriela Niculescu-Aron, Yemi Oluboyede, Marian Sorin Paveliu   +5 more
doaj   +1 more source

Measuring Health and Broader Well-Being Benefits in the Context of Opiate Dependence: The Psychometric Performance of the ICECAP-A and the EQ-5D-5L [PDF]

, 2016
BACKGROUND: Measuring outcomes in economic evaluations of social care interventions is challenging because both health and well-being benefits are evident. The ICEpop CAPability instrument for adults (ICECAP-A) and the five-level EuroQol five-dimensional
Bennett, C, Coast, J, Copello, A, Day, E, Freemantle, N, Frew, E, Goranitis, I, Seddon, J   +7 more
core  

The dual presence of frailty and locomotive syndrome is associated with a greater decrease in the EQ-5D-5L index [PDF]

, 2021
Japan’s aging society is facing an increase in the prevalence of frailty and locomotive syndrome (LS) among older adults. To evaluate the association of these age-related declines on health-related quality of life (QOL) in Japan, we investigated this ...
Ando, Kei, Hasegawa, Yukiharu, Imagama, Shiro, Ishiguro, Naoki, Ishizuka, Shinya, Ito, Sadayuki, Kanbara, Shunsuke, Kanemura, Tokumi, Kobayashi, Kazuyoshi, Machino, Masaaki, Morozumi, Masayoshi, Nakashima, Hiroaki, Seki, Taisuke, Tanaka, Satoshi   +13 more
core