Results 91 to 100 of about 134,162 (275)

Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients [PDF]

, 2015
Aims: To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness ...
Buczek, J, Janssen, MF (Bas), Karlinska, A, Kobayashi, A. (Adam), Niewada, M. (Maciej), Buczek, J. (Julia), Niewada, M, Golicki, D, Janssen, M.F. (Bas), Pickard, A.S. (Simon), Kobayashi, A, Karlińska, A. (Anna), Golicki, D. (Dominik), Pickard, AS   +13 more
core   +2 more sources

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Health status based on EQ-5D-5L for the cancer patient population in Malaysia

Scientific Reports
The EQ-5D is a common generic tool used in clinical trials and economic evaluations to evaluate the health-related quality of life as a proxy of health outcomes.
Sharifa Ezat Wan Puteh, Hasyimah Razali, Aniza Ismail, Malina Zulkifli   +3 more
doaj   +1 more source

Mean (SD) EQ-5D-5L index, level sum score, and EQ VAS scores by respondent’s characteristics.

, 2022
Mean (SD) EQ-5D-5L index, level sum score, and EQ VAS scores by respondent’s characteristics.
Erica I. Lubetkin (9421924), Juanita A. Haagsma (8201781), Di Long (793805), Gouke J. Bonsel (10348491), Mathieu F. Janssen (6645665)   +4 more
core   +1 more source

Multiferroic‐Centric Materials and Systems Engineering for Battery Applications: An Insight Into Mechanisms, Strategies, and Characterizations

Advanced Science, EarlyView.
Multiferroic order parameters – polarization, magnetization, and ferroelastic strain – are positioned as dynamic design variables for batteries. Their mechanistic roles, practical tuning through fabrication and external fields, and ferroic‐resolved characterization routes are unified into a closed‐loop framework, revealing how coupled ferroic responses
Jiaqi Su, Yanda Zhu, Hao Peng, Manman Li, Xuzihan Zhang, Meixiao Wu, Siyuan Zhang, Yuhan Zeng, Jiwen Liao, Ming Luo, Hetaishan Huang, Yutong Wang, Sean Li, Wenxian Li   +13 more
wiley   +1 more source

Implementing routine collection of EQ-5D-5L in a breast cancer outpatient clinic.

PLoS ONE
PurposeA cross-sectional study was conducted to investigate the feasibility of implementing routine collection of the Euro-Qol 5 dimensions (EQ-5D) questionnaire, to inform drug and health technology reimbursement decision making.MethodsWomen with breast
Sofia Torres, Ahmed M Bayoumi, Ana B K Abrahao, Maureen Trudeau, Kathleen I Pritchard, Chun Nim Li, Nicholas Mitsakakis, Geoffrey Liu, Murray Krahn   +8 more
doaj   +1 more source

Responsiveness and minimal clinically important difference of EQ-5D-5L in patients with coronary heart disease after percutaneous coronary intervention: A longitudinal study

Frontiers in Cardiovascular Medicine, 2023
BackgroundAlthough the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L) has been validated in various diseases, no empirical study has evaluated the responsiveness and minimal clinically important difference (MCID) of the ...
Yu Zheng, Yu Zheng, Yu Zheng, Lei Dou, Lei Dou, Lei Dou, Qiang Fu, Shunping Li, Shunping Li, Shunping Li   +9 more
doaj   +1 more source

Health-related quality of life in patients with lower limb amputation – an assessment of the measurement properties of EQ-5D-3L and EQ-5D-5L using data from the Swedish Amputation and Prosthetics Registry

, 2021
To assess the measurement properties of EQ-5D-3L and EQ-5D-5L in patients with a major lower limb amputation (LLA). This was a retrospective register-based study using data from the Swedish Amputation and Prosthetics Registry (SwedeAmp).
Niklas Zethraeus (745299), Olivia Ernstsson (3153873), Kerstin Hagberg (5914595), Emelie Heintz (566679), Seher Korkmaz (7540508), Gouke J. Bonsel (10348491), Mathieu F. Janssen (6645665)   +6 more
core   +1 more source

Parallel Valuation of the EQ-5D-3L and EQ-5D-5L by Time Trade-Offin Hungary [PDF]

, 2020
Objectives The wording of the Hungarian EQ-5D-3L and EQ-5D-5L descriptive systems differ a great deal. This study aimed to (1) develop EQ-5D-3L and EQ-5D-5L value sets for Hungary from a common sample, and (2) compare how level wording affected ...
Golicki, Dominik, Rencz, Fanni, Brodszky, Valentin, Gulácsi, László, Ruzsa, Gábor, Pickard, A. Simon, Law, Ernest H., Péntek, Márta   +7 more
core   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source