Results 91 to 100 of about 104,696 (276)

Validity of the EQ–5D–5L and reference norms for the Spanish population [PDF]

Quality of Life Research, 2018
The EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version and provide index and dimension population-based reference norms for the new EQ-5D-5L.Data were obtained from the 2011/2012 Spanish National Health Survey ...
Gimena Hernandez, Olatz Garin, Yolanda Pardo, Gemma Vilagut, Àngels Pont, Mónica Suárez, Montse Neira, Luís Rajmil, Inigo Gorostiza, Yolanda Ramallo-Fariña, Juan Cabases, Jordi Alonso, Montse Ferrer   +12 more
openaire   +3 more sources

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Health status based on EQ-5D-5L for the cancer patient population in Malaysia

Scientific Reports
The EQ-5D is a common generic tool used in clinical trials and economic evaluations to evaluate the health-related quality of life as a proxy of health outcomes.
Sharifa Ezat Wan Puteh, Hasyimah Razali, Aniza Ismail, Malina Zulkifli   +3 more
doaj   +1 more source

Supplementary_data_Febr2019.rjf_online_supp – Supplemental material for Exploring the Impact of Adding a Respiratory Dimension to the EQ-5D-5L

, 2019
Supplemental material, Supplementary_data_Febr2019.rjf_online_supp for Exploring the Impact of Adding a Respiratory Dimension to the EQ-5D-5L by Martine Hoogendoorn, Mark Oppe, Melinde Boland, Lucas Goossens, Elly Stolk and Maureen Rutten-van Mölken in ...
Lucas Goossens (6736880), Maureen Rutten-van Mölken (3515180), Mark Oppe (3515177), Martine Hoogendoorn (6736877), Melinde Boland (4616242), Elly Stolk (776286)   +5 more
core   +1 more source

Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients [PDF]

, 2015
Aims: To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness ...
Buczek, J, Janssen, MF (Bas), Karlinska, A, Kobayashi, A. (Adam), Niewada, M. (Maciej), Buczek, J. (Julia), Niewada, M, Golicki, D, Janssen, M.F. (Bas), Pickard, A.S. (Simon), Kobayashi, A, Karlińska, A. (Anna), Golicki, D. (Dominik), Pickard, AS   +13 more
core   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Parallel Valuation of the EQ-5D-3L and EQ-5D-5L by Time Trade-Offin Hungary [PDF]

, 2020
Objectives The wording of the Hungarian EQ-5D-3L and EQ-5D-5L descriptive systems differ a great deal. This study aimed to (1) develop EQ-5D-3L and EQ-5D-5L value sets for Hungary from a common sample, and (2) compare how level wording affected ...
Golicki, Dominik, Rencz, Fanni, Brodszky, Valentin, Gulácsi, László, Ruzsa, Gábor, Pickard, A. Simon, Law, Ernest H., Péntek, Márta   +7 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Health-related quality of life in patients with lower limb amputation – an assessment of the measurement properties of EQ-5D-3L and EQ-5D-5L using data from the Swedish Amputation and Prosthetics Registry

, 2021
To assess the measurement properties of EQ-5D-3L and EQ-5D-5L in patients with a major lower limb amputation (LLA). This was a retrospective register-based study using data from the Swedish Amputation and Prosthetics Registry (SwedeAmp).
Niklas Zethraeus (745299), Olivia Ernstsson (3153873), Kerstin Hagberg (5914595), Emelie Heintz (566679), Seher Korkmaz (7540508), Gouke J. Bonsel (10348491), Mathieu F. Janssen (6645665)   +6 more
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source