Results 91 to 100 of about 35,541 (284)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Health status based on EQ-5D-5L for the cancer patient population in Malaysia

Scientific Reports
The EQ-5D is a common generic tool used in clinical trials and economic evaluations to evaluate the health-related quality of life as a proxy of health outcomes.
Sharifa Ezat Wan Puteh, Hasyimah Razali, Aniza Ismail, Malina Zulkifli   +3 more
doaj   +1 more source

EQ-5D-5L norms for the urban Chinese population in China

Health and Quality of Life Outcomes, 2018
Background To generate Chinese population norms for the EQ-5D-5L dimensions, EQ-VAS (Visual Analogue Scale) scores and EQ-5D-5L index scores, stratified by gender and age.
Zhihao Yang, Jan Busschbach, Gordon Liu, Nan Luo   +3 more
doaj   +1 more source

การเปรียบเทียบ 5 วิธีในการวัดค่าอรรถประโยชน์ของคุณภาพชีวิตด้านสุขภาพ ของนักศึกษาปริญญาตรี A Comparison of Five Approaches for Measuring Utility Values of Health-related Quality of Life among Undergraduate Students [PDF]

, 2023
บทคัดย่อ   วัตถุประสงค์: เพื่อทดสอบคุณสมบัติและความสอดคล้องกันของคะแนนอรรถประโยชน์จาก 5 วิธี คือ EQ-5D-3L, EQ-5D-5L (cTTO model), EQ-5D-5L (DCE model), EQ-5D-5L (Hybrid model) และ VAS ของนักศึกษาระดับปริญญาตรี วิธีการศึกษา: การศึกษาเชิงสำรวจแบบภาพต ...
Chatsirinoppakhun, Chaiphat, Kangwanrattanakul, Krittaphas, Laplerdloy , Pattara, Panyasri, Nutthathida   +3 more
core   +1 more source

Time perspective profile and self-reported health on the EQ-5D [PDF]

, 2023
Objectives: Time perspective (TP) is a psychological construct that is associated with several health-related behaviours, including healthy eating, smoking and adherence to medications.
Janssen, Mathieu F., Rencz, Fanni
core   +3 more sources

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Cross-walk of the Chronic Liver Disease Questionnaire for Nonalcoholic Steatohepatitis (CLDQ-NASH) and the EuroQol EQ-5D-5L in patients with NASH

Health and Quality of Life Outcomes, 2023
Background Nonalcoholic steatohepatitis (NASH) is a chronic progression of nonalcoholic fatty liver disease, which can negatively impact the health-related quality of life (HRQoL) of affected individuals. HRQoL in NASH has been assessed using the disease-
Jesse Fishman, Victoria Higgins, James Piercy, James Pike   +3 more
doaj   +1 more source

Validity of the EQ–5D–5L and reference norms for the Spanish population [PDF]

Quality of Life Research, 2018
The EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version and provide index and dimension population-based reference norms for the new EQ-5D-5L.Data were obtained from the 2011/2012 Spanish National Health Survey ...
Gimena Hernandez, Olatz Garin, Yolanda Pardo, Gemma Vilagut, Àngels Pont, Mónica Suárez, Montse Neira, Luís Rajmil, Inigo Gorostiza, Yolanda Ramallo-Fariña, Juan Cabases, Jordi Alonso, Montse Ferrer   +12 more
openaire   +3 more sources

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source