Results 81 to 90 of about 35,541 (284)

Psychometrics and validation of the EQ-5D-5L instrument in individuals with ischemic stroke in Lithuania

Frontiers in Psychology, 2023
BackgroundExperiencing stroke is associated with deterioration in health-related quality of life (HRQL). One of the generic tools used for HRQL assessment is the EuroQol instrument of five dimensions and five levels (EQ-5D-5L), which has not yet been ...
Saulius Taroza, Julius Burkauskas, Narseta Mickuviene, Nijole Kazukauskiene, Aurelija Podlipskyte   +4 more
doaj   +1 more source

A Validation Study of the EQ-5D-5L and ICEpop Capability Measure for Older People Among Older Individuals With Depressive Symptoms in Brazil [PDF]

, 2022
ObjectivesThis study aimed to assess the known-groups validity of the EQ-5D-5L and the ICECAP-O, two outcome measures used in economic evaluation, among older adults with depressive symptoms in socio-economically deprived areas of Brazil.
Araya, Ricardo, Hollingworth, William, Mitchell, Paul M, Moreno-Agostino , Darío, Nakamura, Carina Akemi, Peters, TJ, Scazufca , Marcia   +6 more
core   +2 more sources

Measurement properties of the EQ-5D-5L and PROPr in patients with spinal muscular atrophy

Health and Quality of Life Outcomes, 2023
Objectives Spinal muscular atrophy (SMA) is a rare monogenic neuromuscular disorder caused by loss of function mutations. Measuring health-related quality of life to support economic evaluations in this population is encouraged.
Richard Huan Xu, Bin Ma, Huanping Xin, Huanyu Zhang, Yan Zeng, Nan Luo, Dong Dong   +6 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Measuring health related quality of life of care home residents, comparison of self-report with staff proxy responses for EQ-5D-5L and HowRu: protocol for assessing proxy reliability in care home outcome testing [PDF]

, 2018
Introduction Research into interventions to improve health and wellbeing for older people living in care homes is increasingly common. Health-Related Quality of Life (HRQoL) is frequently used as an outcome measure but collecting both self-reported and ...
Dening, T., Gage, H., Gage, H., Gladman, J.R.F., Gordon, A., Hinsliff-Smith, K., Housley, G., Jordan, J., Lewis, S., Long, A., Usman, A.   +10 more
core   +4 more sources

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Responsiveness and minimal clinically important difference of EQ-5D-5L in patients with coronary heart disease after percutaneous coronary intervention: A longitudinal study

Frontiers in Cardiovascular Medicine, 2023
BackgroundAlthough the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L) has been validated in various diseases, no empirical study has evaluated the responsiveness and minimal clinically important difference (MCID) of the ...
Yu Zheng, Yu Zheng, Yu Zheng, Lei Dou, Lei Dou, Lei Dou, Qiang Fu, Shunping Li, Shunping Li, Shunping Li   +9 more
doaj   +1 more source

The Development of the EQ-5D-5L and its Value Sets

, 2022
AbstractThis chapter introduces the EQ-5D-5L questionnaire and its development by the EuroQol Group. The availability of the EQ-5D-5L, and the growing evidence of its pivotal role as a measurement system, generated a demand for ‘values’ to accompany it that would enable the use of EQ-5D-5L data in the estimation of quality-adjusted life-years (QALYs ...
Devlin, N, Pickard, S, Busschbach, J
openaire   +2 more sources

Exploring The Impact of Adding A Respiratory Dimension to The EQ-5D-5L [PDF]

Value in Health, 2016
Objectives. To evaluate the impact of adding a respiratory dimension (a bolt-on dimension) to the EQ-5D-5L health state valuations. Methods. Based on extensive regression and principal component analyses, 2 respiratory bolt-on candidates were formulated: R1, limitations in physical activities due to shortness of breath, and R2, breathing problems ...
Martine Hoogendoorn, Mark Oppe, Melinde R. S. Boland, Lucas M. A. Goossens, Elly A. Stolk, Maureen P. M. H. Rutten–van Mölken   +5 more
openaire   +3 more sources

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source