Results 81 to 90 of about 104,696 (276)

Measurement properties of the EQ-5D-5L and PROPr in patients with spinal muscular atrophy

Health and Quality of Life Outcomes, 2023
Objectives Spinal muscular atrophy (SMA) is a rare monogenic neuromuscular disorder caused by loss of function mutations. Measuring health-related quality of life to support economic evaluations in this population is encouraged.
Richard Huan Xu, Bin Ma, Huanping Xin, Huanyu Zhang, Yan Zeng, Nan Luo, Dong Dong   +6 more
doaj   +1 more source

A review of health utilities using the EQ-5D in studies of cardiovascular disease

, 2010
Background The EQ-5D has been extensively used to assess patient utility in trials of new treatments within the cardiovascular field. The aims of this study were to review evidence of the validity and reliability of the EQ-5D, and to summarise utility ...
Buxton, Martin J, Goldsmith Kimberley A, Buxton Martin J, Kimberley A Goldsmith, Goldsmith, Kimberley A, Dyer, Matthew TD, Dyer, MT, Dyer, Matthew T D, Matthew TD Dyer, Sharples, L, Goldsmith, Kimberley A; id_orcid, Sharples Linda S, Dyer Matthew TD, Goldsmith, KA, Martin J Buxton, Sharples, Linda S, Linda S Sharples, Buxton, MJ   +17 more
core   +1 more source

Mean (SD) EQ-5D-5L index, level sum score, and EQ VAS scores by respondent’s characteristics.

, 2022
Mean (SD) EQ-5D-5L index, level sum score, and EQ VAS scores by respondent’s characteristics.
Erica I. Lubetkin (9421924), Juanita A. Haagsma (8201781), Di Long (793805), Gouke J. Bonsel (10348491), Mathieu F. Janssen (6645665)   +4 more
core   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

EQ-5D-5L norms for the urban Chinese population in China

Health and Quality of Life Outcomes, 2018
Background To generate Chinese population norms for the EQ-5D-5L dimensions, EQ-VAS (Visual Analogue Scale) scores and EQ-5D-5L index scores, stratified by gender and age.
Zhihao Yang, Jan Busschbach, Gordon Liu, Nan Luo   +3 more
doaj   +1 more source

Responsiveness and minimal clinically important difference of EQ-5D-5L in patients with coronary heart disease after percutaneous coronary intervention: A longitudinal study

Frontiers in Cardiovascular Medicine, 2023
BackgroundAlthough the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L) has been validated in various diseases, no empirical study has evaluated the responsiveness and minimal clinically important difference (MCID) of the ...
Yu Zheng, Yu Zheng, Yu Zheng, Lei Dou, Lei Dou, Lei Dou, Qiang Fu, Shunping Li, Shunping Li, Shunping Li   +9 more
doaj   +1 more source

Exploring The Impact of Adding A Respiratory Dimension to The EQ-5D-5L [PDF]

Value in Health, 2016
Objectives. To evaluate the impact of adding a respiratory dimension (a bolt-on dimension) to the EQ-5D-5L health state valuations. Methods. Based on extensive regression and principal component analyses, 2 respiratory bolt-on candidates were formulated: R1, limitations in physical activities due to shortness of breath, and R2, breathing problems ...
Martine Hoogendoorn, Mark Oppe, Melinde R. S. Boland, Lucas M. A. Goossens, Elly A. Stolk, Maureen P. M. H. Rutten–van Mölken   +5 more
openaire   +3 more sources

Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions

, 2009
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Buxton, Martin J, Schofield, Peter M, Peter M Schofield, Kimberley A Goldsmith, Sharples, LD, Goldsmith, Kimberley A, Dyer, MT, Sharples, Linda D, Schofield, PM, Goldsmith, Kimberley A; id_orcid, Matthew T Dyer, Linda D Sharples, Goldsmith, KA, Dyer, Matthew T, Martin J Buxton, Buxton, MJ   +15 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

The Development of the EQ-5D-5L and its Value Sets

, 2022
AbstractThis chapter introduces the EQ-5D-5L questionnaire and its development by the EuroQol Group. The availability of the EQ-5D-5L, and the growing evidence of its pivotal role as a measurement system, generated a demand for ‘values’ to accompany it that would enable the use of EQ-5D-5L data in the estimation of quality-adjusted life-years (QALYs ...
Devlin, N, Pickard, S, Busschbach, J
openaire   +2 more sources