Results 111 to 120 of about 104,696 (276)

Three Component Thio‐ and Carboboration of Alkynes: A Modular Route to Functionalised Bicyclic Boronates

Angewandte Chemie, EarlyView.
Three‐component thio‐ and carbo‐boration reactions to form functionalised benzoxaborinines and benzazaborinines are reported. The nucleophile scope includes thioethers, thiols, and (hetero)arenes. Mechanistic studies revealed a disparity between thioboration using thioethers and using thiols.
Laura Winfrey, Gary S. Nichol, Stephen P. Thomas, Dominic R. Willcox, Michael. J. Ingleson   +4 more
wiley   +2 more sources

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Construct validity of EQ-5D-5L among patients with inflammatory bowel disease—a study based on real-world data from the Swedish Inflammatory Bowel Disease Registry

Journal of Patient-Reported Outcomes
Objectives The Swedish Inflammatory Bowel Disease Registry (SWIBREG) includes approximately 84% of all patients with inflammatory bowel disease (IBD) treated with immunomodulators, biologics or surgery in Sweden.
Jack Latteur, Olivia Ernstsson, Evalill Nilsson, Susanna Jäghult, Emelie Heintz   +4 more
doaj   +1 more source

EQ-5D-5L index (mean, 95% confidence interval) according to age group: Comparison of respondents with diabetes versus no diabetes and the general population.

, 2021
EQ-5D-5L index (mean, 95% confidence interval) according to age group: Comparison of respondents with diabetes versus no diabetes and the general population.
Dominik Golicki (11502378), Agnieszka Jankowska (10175413)   +1 more
core   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

EQ-5D-5L index (mean, 95% confidence interval) according to education level: Comparison of respondents with diabetes versus no diabetes and the general population.

, 2021
EQ-5D-5L index (mean, 95% confidence interval) according to education level: Comparison of respondents with diabetes versus no diabetes and the general population.
Dominik Golicki (11502378), Agnieszka Jankowska (10175413)   +1 more
core   +1 more source

Experimental Design for the Valuation of the EQ-5D-5L

, 2022
AbstractThe EQ-VT protocol for valuing the EQ-5D-5L offered the opportunity to develop a standardised experimental design to elicit EQ-5D-5L values. This chapter sets out the various aspects of the EQ-VT design and the basis on which methodological choices were made in regard to the stated preference methods used, i.e., composite time trade-off (cTTO ...
Mark Oppe, Richard Norman, Zhihao Yang, Ben van Hout   +3 more
openaire   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

A Periosteum‐Inspired Janus Piezoelectric Scaffold Using Bioenergetic‐Driven H‐Type Vascularization for Diabetic Bone Regeneration

Advanced Science, EarlyView.
A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley   +1 more source

Mean (SD) of deviations from reference norms: EQ-5D-5L index and EQ-VAS.

, 2018
Mean (SD) of deviations from reference norms: EQ-5D-5L index and EQ-VAS.
Eric Van Ganse (5680409), Montse Ferrer (436419), Marc Martí-Pastor (5639900), Àngels Pont (5680406), Gimena Hernandez (5680400), Laurent Laforest (5680412), Marijn de Bruin (309168), Alexandra L. Dima (5680403), Olatz Garin (178963), Jordi Alonso (178939), Karina Mayoral (5680415)   +10 more
core   +1 more source