Results 131 to 140 of about 134,162 (275)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Predicting EQ-5D-5L Utility Scores from the Oswestry Disability Index and Roland-Morris Disability Questionnaire for Low Back Pain

Journal of Pain Research, 2020
Thomas G Poder,1– 3 Nathalie Carrier3 1School of Public Health, Department of Management, Evaluation and Health Policy, University of Montreal, Montreal, QC, Canada; 2Centre de recherche de l’Institut universitaire en santé mentale de ...
Poder TG, Carrier N
doaj  

A comparison of values in the EQ-5D-3L value set and the EQ-5D-5L crosswalk value set for Trinidad and Tobago.

, 2019
A comparison of values in the EQ-5D-3L value set and the EQ-5D-5L crosswalk value set for Trinidad and Tobago.
Althea La Foucade (6645668), Henry Bailey (6645662), Paul Kind (6645671), Mathieu F. Janssen (6645665)   +3 more
core   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Measuring quality of life in COPD patients: comparing disease-specific supplements to the EQ-5D-5L

, 2019
Objectives: Patients with chronic obstructive pulmonary disease (COPD) show impairments in health-related quality of life (HRQL). We aimed to find a disease-specific questionnaire for routine application in large cohorts and to assess its additional ...
Larissa Schwarzkopf (3400349), Boglárka Lilla Szentes (7376315), Florian Kirsch (821794), Reiner Leidl (671541), Anja Schramm (7376318)   +4 more
core   +1 more source

Scale and rate heterogeneity in the EQ-5D-5L valuation

Health and Quality of Life Outcomes
Abstract Objectives To estimate values on a quality-adjusted life year (QALY) scale using individual preference evidence, choice analyses typically include ancillary parameters, such as scale factors and discount rates. These parameters potentially differ among respondents.
Jumamyradov, Maksat, Craig, Benjamin, Michał Jakubczyk   +2 more
openaire   +4 more sources

Social Determinants of Health and Health‐Related Quality of Life: The Potential Mediating Role of Social Activities, Access to Medical Services, and Access to Social Services

Australian Journal of Social Issues, EarlyView.
ABSTRACT This study explored the mediating influences of access to social activities, social services, and health and medical services on the relationship between social determinants of health and health‐related quality of life. A survey of 602 adults was conducted in a regional area of Australia.
Candice Oster, Ashleigh Powell, Claire Hutchinson, Richard Leibbrandt, Svetlana Bogomolova   +4 more
wiley   +1 more source

Validity of the Eq-5d-5l in Stroke Patients [PDF]

Value in Health, 2014
Golicki, D., Niewada, M., Buczek, J., Karlinska, A., Kobayashi, A., Janssen, M.F., Pickard, A.S.   +6 more
openaire   +2 more sources

Association Between Genetic Ancestry and Multiple Sclerosis Severity

Annals of Neurology, EarlyView.
Objective The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). Methods Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyped from saliva using a commercial array. Genetic ancestry was inferred using
Benjamin M. Jacobs, Emily Tregaskis‐Daniels, Luisa Schalk, Jakub Nagrodski, ADAMS investigators, Michelle Peter, Rashmi Kaimal, Roxanne Murray, Sadid Hoque, Terri‐Louise Brown, Ghaniah Hassan‐Smith, Helen L. Ford, Bruno Gran, Karim L. Kreft, Cord Spilker, Outi Quinn, David Rog, Miriam Mattoscio, Elisa Visentin, Ramya Shamji, Grace Fawehinmi, Katila George, Maria Papachatzaki, Katharine Harding, Rod Middleton, Tarunya Arun, Waqar Rashid, Adil Harroud, Huw R. Morris, Eli Silber, Gavin Giovannoni, Alastair J. Noyce, Ruth Dobson   +32 more
wiley   +1 more source

Appropriateness of the EQ-5D-5L in capturing health-related quality of life in individuals with transfusion-dependent β-thalassemia: a mixed methods study

Health and Quality of Life Outcomes
Background Individuals with transfusion-dependent β-thalassemia (TDT) experience symptoms and functional impacts that reduce their health-related quality of life.
Adriana Boateng-Kuffour, Hanna Skrobanski, Jennifer Drahos, Puja Kohli, Katie Forster, Sarah Acaster, Zahra Pakbaz, Nanxin Li, Kate Williams   +8 more
doaj   +1 more source