Results 131 to 140 of about 35,541 (284)

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

open access: yesAdvanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang   +10 more
wiley   +1 more source

Population Norms for the EQ-5D-5L, PROPr and SF-6D in Hungary [PDF]

open access: yes
Objectives: This study aimed to develop population norms for three preference-accompanied measures [EQ-5D-5L, Patient-Reported Outcomes Measurement Information System (PROMIS)-preference scoring system (PROPr) and Short-Form Six-Dimension (SF-6D)] in ...
Brodszky, Valentin   +4 more
core   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

open access: yesAdvanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang   +23 more
wiley   +1 more source

EQ-5D-5L valuation project for the Spanish population: a descriptive overview and preliminary results [PDF]

open access: yes, 2013
The latest EQ-5D instrument, EQ-5D-5L, needs new country-specific valuation studies to obtain a value set adapted to the characteristics of the updated instrument.
Cabasés Hita, Juan Manuel   +4 more
core  

EQ-5D-5L Value Set Summaries

open access: yes, 2022
AbstractThis chapter provides structured summaries of all 25 currently published national EQ-5D-5L value sets. The summaries were developed by extracting information from the published manuscripts of each value set and conducting secondary data analyses of the original valuation data generated in each country/region.
Bram Roudijk   +2 more
openaire   +1 more source

Social Determinants of Health and Health‐Related Quality of Life: The Potential Mediating Role of Social Activities, Access to Medical Services, and Access to Social Services

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT This study explored the mediating influences of access to social activities, social services, and health and medical services on the relationship between social determinants of health and health‐related quality of life. A survey of 602 adults was conducted in a regional area of Australia.
Candice Oster   +4 more
wiley   +1 more source

Comparison of the EQ-5D-3L and EQ-5D-5L instruments in patients undergoing unicompartmental knee arthroplasty

open access: yesFrontiers in Medicine
PurposeThe purpose of this investigation is to assess and contrast the effectiveness of the two EuroQol five dimensions questionnaire (EQ-5D) versions—EQ-5D-3L and EQ-5D-5L—in assessing one-year quality of life outcomes for patients with knee ...
Zhipeng Tai   +5 more
doaj   +1 more source

Predicting EQ-5D-5L Utility Scores from the Oswestry Disability Index and Roland-Morris Disability Questionnaire for Low Back Pain

open access: yesJournal of Pain Research, 2020
Thomas G Poder,1– 3 Nathalie Carrier3 1School of Public Health, Department of Management, Evaluation and Health Policy, University of Montreal, Montreal, QC, Canada; 2Centre de recherche de l’Institut universitaire en santé mentale de ...
Poder TG, Carrier N
doaj  

The construct validity and responsiveness of the EQ-5D-5L, AQL-5D and a bespoke TTO in acute asthmatics [PDF]

open access: yes, 2019
Purpose: Measuring quality of life in acute asthmatics is challenging, especially when asthma attacks can occur sporadically. Several questionnaires can be used to measure quality of life in this patient group; however, psychometric testing is limited on
Barton, Garry   +3 more
core   +1 more source

New craniodental materials of Falcarius utahensis (Theropoda: Therizinosauria) reveal patterns of intraspecific variation and cranial evolution in early coelurosaurians

open access: yesThe Anatomical Record, EarlyView.
Abstract Despite documented ecomorphological shifts toward an herbivorous diet in several coelurosaurian lineages, the evolutionary tempo and mode of these changes remain poorly understood, hampered by sparse cranial materials for early representatives of major clades. This is particularly true for Therizinosauria, with representative crania best known
William J. Freimuth, Lindsay E. Zanno
wiley   +1 more source

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