Results 91 to 100 of about 40,172 (233)

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

(Re)-conciliation of genetics and genomics approaches for cotton fiber quality improvement [PDF]

, 2008
The integration of genomics and plant breeding is driven by the increasing availability of sequence resources and by technological developments. The simultaneous measurement of the expression of thousands of genes is possible, and comparisons between ...
Al-Ghazi, Yves, Arioli, Tony, Claverie, Michel, Dennis, Elizabeth, Derycker, Ruud, Forestier-Chiron, Nelly, Giband, Marc, Jacobs, John, Jean, Janine, Lacape, Jean-Marc, Llewellyn, Danny, Viot, Christopher   +11 more
core  

Unsupervised empirical Bayesian multiple testing with external covariates

, 2008
In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true.
Ferkingstad, Egil, Frigessi, Arnoldo, Kong, Augustine, Rue, Håvard, Thorleifsson, Gudmar   +4 more
core   +2 more sources

Allele-specific expression and eQTL analysis in mouse adipose tissue. [PDF]

, 2014
BackgroundThe simplest definition of cis-eQTLs versus trans, refers to genetic variants that affect expression in an allele specific manner, with implications on underlying mechanism.
Drake, Thomas A, Eskin, Eleazar, Hasin-Brumshtein, Yehudit, Hormozdiari, Farhad, Lusis, Aldons J, Martin, Lisa, van Nas, Atila   +6 more
core   +2 more sources

eQTLs in Glioblastoma Multiforme

, 2013
Like all cancers, Glioblastoma multiforme (GBM), the most common and deadly primary brain tumor, is an evolutionary disease: mutations in glial cell lineages change gene expression, leading to tumor growht and metastatic disease. How genomic changes influence gene expression is not well understood.
Lab, Claus Wilke, Shpak, Max, Hall, Amelia, Goldberg, Marcus, Derryberry, Dakota Z., Cowperthwaite, Matthew C.   +5 more
openaire   +1 more source

TreeQTL: hierarchical error control for eQTL findings [PDF]

Bioinformatics, 2015
Abstract Summary: Commonly used multiplicity adjustments fail to control the error rate for reported findings in many expression quantitative trait loci (eQTL) studies. TreeQTL implements a hierarchical multiple testing procedure which allows control of appropriate error rates defined relative to a grouping of the eQTL hypotheses.
Peterson, Christine, Bogomolov, Marina, Benjamini, Yoav, Sabatti, Chiara   +3 more
openaire   +3 more sources

Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High‐Altitude Adaptive Genetic Variants in Sherpa Highlanders

Annals of Human Genetics, EarlyView.
ABSTRACT Background and Aims Sherpa highlanders exhibit remarkable tolerance to hypoxia, most likely due to genetic adaptations shaped by natural selection at high altitude. This study examined the roles of endothelial PAS domain protein 1 (EPAS1) and egl‐9 family hypoxia‐inducible factor 1 (EGLN1) in the genetic mechanisms underlying this adaptation ...
Yunden Droma, Fengming Yue, Masao Ota, Nobumitsu Kobayashi, Yoshiaki Kitaguchi, Masayuki Hanaoka   +5 more
wiley   +1 more source

Genetic regulation of mouse liver metabolite levels. [PDF]

, 2014
We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J, Che, Nam, Ghazalpour, Anatole, Hagopian, Raffi, He, Aiqing, Kayne, Paul, Kirchgessner, Todd, Lusis, Aldons J, Orozco, Luz, Pan, Calvin, Shih, Diana, Yang, Wen-pin   +11 more
core   +1 more source

Genetic control of longissimus dorsi muscle gene expression variation and joint analysis with phenotypic quantitative trait loci in pigs

BMC Genomics, 2019
Background Economically important growth and meat quality traits in pigs are controlled by cascading molecular events occurring during development and continuing throughout the conversion of muscle to meat.
Deborah Velez-Irizarry, Sebastian Casiro, Kaitlyn R. Daza, Ronald O. Bates, Nancy E. Raney, Juan P. Steibel, Catherine W. Ernst   +6 more
doaj   +1 more source

Segregation of regulatory polymorphisms with effects on the gluteus medius transcriptome in a purebred pig population.

PLoS ONE, 2012
BackgroundThe main goal of the present study was to analyse the genetic architecture of mRNA expression in muscle, a tissue with an outmost economic importance for pig breeders.
Angela Cánovas, Ramona N Pena, David Gallardo, Oscar Ramírez, Marcel Amills, Raquel Quintanilla   +5 more
doaj   +1 more source