Results 91 to 100 of about 41,400 (238)

Unsupervised empirical Bayesian multiple testing with external covariates

, 2008
In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true.
Ferkingstad, Egil, Frigessi, Arnoldo, Kong, Augustine, Rue, Håvard, Thorleifsson, Gudmar   +4 more
core   +2 more sources

Pathway‐Informed Machine Learning Identifies Genetic Predictors of High‐Dose Methotrexate‐Induced Mucositis in Pediatric Acute Lymphoblastic Leukemia

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 447-456, February 2026.
High‐dose methotrexate for pediatric cancer treatment is frequently associated with mucositis, which can lead to delayed or discontinued treatment and impact survival. While individual genetic variants have been implicated, the cumulative impact of genetic variation within relevant biological pathways remains unexplored.
Xiao Yu Cindy Zhang, Erika N. Scott, Hedy Maagdenberg, Alice Man, Kathy H. Li, S. Rod Rassekh, Bruce C. Carleton, Colin J. D. Ross, Wyeth W. Wasserman, Catrina M. Loucks   +9 more
wiley   +1 more source

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Longevity and muscle strength are heritable traits, and age‐related muscle weakness is a major contributor to disability in older adults. However, the susceptibility genes and shared genetic mechanisms underlying lifespan and sarcopenia remain unclear.
Yilong Lin, Yun Zhang, Shengjie Lin, Songsong Wang, Zhiqiang Que, Yue Zhang, Jing She, Ruidan Zhao, Jiawei Chen, Anqi Qiu, Shinan Wu, Ruiqin Yang, Liyi Zhang, Qingmo Yang   +13 more
wiley   +1 more source

Insights Into Hereditary Alpha‐Tryptasemia From a Genome‐Wide Association Study in Hymenoptera Venom Anaphylaxis

Clinical &Experimental Allergy, EarlyView.
Teresa Blanco‐Ramos, Raquel Cruz, Irene Fernández‐Franco, Mª Ángeles Vargas, Ángel Carracedo, Arturo González‐Quintela, Carmen Vidal   +6 more
wiley   +1 more source

A Genome‐Wide Association Study Reveals Desmoglein‐2 Predominance in Japanese Arrhythmogenic Cardiomyopathy

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
A GWAS of Japanese arrhythmogenic cardiomyopathy identified a strong signal near DSG2, exceeding the genome‐wide significance of p = 5 × 10–8 (red line). This signal disappeared after excluding carriers of rare DSG2 variants. Stratified analyses indicate that the association reflects a DSG2‐D494A‐mediated synthetic effect driven predominantly by this ...
Taisuke Ishikawa, Kyuto Sonehara, Keiko Sonoda, Kenshi Hayashi, Koichi Kato, Satoshi Nagase, Kengo Kusano, Takeshi Aiba, Minoru Horie, Seiko Ohno, Yukinori Okada, Naomasa Makita   +11 more
wiley   +1 more source

Potential Targets Related to Skin Aging: Based on eQTL and GWAS Datasets

Clinical, Cosmetic and Investigational Dermatology
Hanping Shi,1,2 Xianwei Cao1– 3 1School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University,
Shi H, Cao X
doaj  

SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies

BMC Genetics, 2019
Background Over the relatively short history of Genome Wide Association Studies (GWASs), hundreds of GWASs have been published and thousands of disease risk-associated SNPs have been identified.
Ivan Gorlov, Xiangjun Xiao, Maureen Mayes, Olga Gorlova, Christopher Amos   +4 more
doaj   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

eQTL Viewer: visualizing how sequence variation affects genome-wide transcription

BMC Bioinformatics, 2007
Background Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expression profiles are related with sequence polymorphisms across the genome ...
Zeng Zhao-Bang, Aylor David L, Zou Wei
doaj   +1 more source

An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells [PDF]

, 2023
Juan I. Bravo, Chanelle R. Mizrahi, Seungsoo Kim, Lucia Zhang, Yousin Suh, Bérénice A. Benayoun   +5 more
openalex   +1 more source